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Electrophoretic Separation of Nanoparticles with a Discrete Number of Functional Groups
Abstract
A concept is describe that facilitates the modification of colloidal nanoparticles of different materials with an exactly known number of variable functional groups. In particular, a procedure for the surface functionalization of nanoparticles with a controlled number of mono‐ or bifunctional poly(ethylene glycol) (PEG) molecules of suitable chain length is reported. Conjugates of nanoparticles with one, two, and three PEG molecules per nanoparticle could be separated using gel electrophoresis. Molecules with additional functionalities could be conjugated to the free ends of the bifunctional PEG molecules. In this way the PEG molecules act as convenient spacers that allow for the sorting of nanoparticles with a discrete number of functional groups.
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Cited by
Pelaz, B., del Pino, P., Maffre, P., Hartmann, R., Gallego, M., Rivera-Fernández, S., de la Fuente, J. M., Nienhaus, G. U., & Parak, W. J. (2015) · ACS Nano · doi:10.1021/acsnano.5b01326 · Cited by 890
Self-citationGuardia, P., Di Corato, R., Lartigue, L., Wilhelm, C., Espinosa, A., Garcia-Hernandez, M., Gazeau, F., Manna, L., & Pellegrino, T. (2012) · ACS Nano · doi:10.1021/nn2048137 · Cited by 752
Self-citationLin, C.-A. J., Yang, T.-Y., Lee, C.-H., Huang, S. H., Sperling, R. A., Zanella, M., Li, J. K., Shen, J.-L., Wang, H.-H., Yeh, H.-I., et al. (2009) · ACS Nano · doi:10.1021/nn800632j · Cited by 731
Self-citationZinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism
Król, A., Pomastowski, P., Rafińska, K., Railean-Plugaru, V., & Buszewski, B. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.07.033 · Cited by 731
Design of an Amphiphilic Polymer for Nanoparticle Coating and Functionalization
Lin, C. J., Sperling, R. A., Li, J. K., Yang, T., Li, P., Zanella, M., Chang, W. H., & Parak, W. J. (2008) · Small · doi:10.1002/smll.200700654 · Cited by 461
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Metadata
- Authors
- Sperling, R. A., Pellegrino, T., Li, J. K., Chang, W. H., & Parak, W. J.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2006-04-12
- Volume
- 16
- Issue
- 7
- Pages
- 943-948
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2056120938
- Cited by
- 209
- References
- 0
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sperling, R. A., Pellegrino, T., Li, J. K., Chang, W. H., & Parak, W. J. (2006). Electrophoretic Separation of Nanoparticles with a Discrete Number of Functional Groups. Advanced Functional Materials. https://doi.org/10.1002/adfm.200500589
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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