Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment
Abstract
Iron oxide nanocrystals (IONCs) are appealing heat mediator nanoprobes in magnetic-mediated hyperthermia for cancer treatment. Here, specific absorption rate (SAR) values are reported for cube-shaped water-soluble IONCs prepared by a one-pot synthesis approach in a size range between 13 and 40 nm. The SAR values were determined as a function of frequency and magnetic field applied, also spanning technical conditions which are considered biomedically safe for patients. Among the different sizes tested, IONCs with an average diameter of 19 ± 3 nm had significant SAR values in clinical conditions and reached SAR values up to 2452 W/g(Fe) at 520 kHz and 29 kAm(-1), which is one of the highest values so far reported for IONCs. In vitro trials carried out on KB cancer cells treated with IONCs of 19 nm have shown efficient hyperthermia performance, with cell mortality of about 50% recorded when an equilibrium temperature of 43 °C was reached after 1 h of treatment.
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Guardia et al. observed a linear SAR dependence as a function of frequency at a fixed amplitude and a quadratic SAR dependence as a function of amplitude at a fixed frequency for water-soluble iron oxide nanocubes.
“Interestingly, Guardia et al. observed a linear SAR dependence as a function of frequency (at a fixed amplitude) and a quadratic SAR dependence as a function of amplitude (at a fixed frequency) for water-soluble iron oxide nanocubes [15, 115].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [115]
Cites
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.012 · Cited by 6,795 · see citing works
Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles
Sun, S., Zeng, H., Robinson, D., Raoux, S., Rice, P. M., Wang, S. X., & Li, G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0380852 · Cited by 3,441 · see citing works
Preparation of aqueous magnetic liquids in alkaline and acidic media
Massart, R. (1981) · IEEE Transactions on Magnetics · doi:10.1109/tmag.1981.1061188 · Cited by 2,818 · see citing works
Heating magnetic fluid with alternating magnetic field
Rosensweig, R. E. (2002) · Journal of Magnetism and Magnetic Materials · doi:10.1016/s0304-8853(02)00706-0 · Cited by 2,552 · see citing works
Magnetic nanoparticle design for medical diagnosis and therapy
Mornet, S., Vasseur, S., Grasset, F., & Duguet, É. (2004) · Journal of Materials Chemistry · doi:10.1039/b402025a · Cited by 1,745 · see citing works
Neuberger, T., Schöpf, B., Hofmann, H., Hofmann, M., & von Rechenberg, B. (2005) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2005.01.064 · Cited by 1,727 · see citing works
Progress in applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Thanh, N. T. K., Jones, S. K., & Dobson, J. (2009) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/42/22/224001 · Cited by 1,452 · see citing works
Static and dynamic magnetic properties of spherical magnetite nanoparticles
Goya, G. F., Berquó, T. S., Fonseca, F. C. C., & Morales, M. P. (2003) · Journal of Applied Physics · doi:10.1063/1.1599959 · Cited by 1,393 · see citing works
Exchange-coupled magnetic nanoparticles for efficient heat induction
Lee, J., Jang, J.-T., Choi, J., Moon, S. H., Noh, S.-H., Kim, J.-W., Kim, J., Kim, I., Park, K. I., & Cheon, J. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.95 · Cited by 1,365 · see citing works
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake
Zhang, Y., Kohler, N., & Zhang, M. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00267-8 · Cited by 1,266 · see citing works
Magnetosome formation in prokaryotes
Bazylinski, D. A., & Frankel, R. B. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro842 · Cited by 1,214 · see citing works
Pellegrino, T., Manna, L., Kudera, S., Liedl, T., Koktysh, D. S., Rogach, A. L., Keller, S., Rädler, J. O., Natile, G., & Parak, W. J. (2004) · Nano Letters · doi:10.1021/nl035172j · Cited by 1,067 · see citing works
Self-citationSize-Sorted Anionic Iron Oxide Nanomagnets as Colloidal Mediators for Magnetic Hyperthermia
Fortin, J.-P., Wilhelm, C., Servais, J., Ménager, C., Bacri, J.-C., & Gazeau, F. (2007) · Journal of the American Chemical Society · doi:10.1021/ja067457e · Cited by 1,039 · see citing works
Self-citationMagnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy
Hergt, R., Dutz, S., Müller, R., & Zeisberger, M. (2006) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/18/38/s26 · Cited by 977 · see citing works
Magnetic particle hyperthermia—biophysical limitations of a visionary tumour therapy
Hergt, R., & Dutz, S. (2006) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2006.10.1156 · Cited by 927 · see citing works
Clinical applications of magnetic nanoparticles for hyperthermia
Thiesen, B., & Jordan, A. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730802104757 · Cited by 829 · see citing works
Maier-Hauff, K., Rothe, R., Scholz, R., Gneveckow, U., Wust, P., Thiesen, B., Feussner, A., von Deimling, A., Waldöfner, N., Felix, R., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9195-0 · Cited by 772 · see citing works
Formation of uniform spherical magnetite particles by crystallization from ferrous hydroxide gels
Sugimoto, T., & Matijević, E. (1980) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(80)90187-3 · Cited by 648 · see citing works
Synthesis of monodisperse iron oxide nanocrystals by thermal decomposition of iron carboxylate salts
Yu, W. W., Falkner, J. C., Yavuz, C. T., & Colvin, V. L. (2004) · Chemical Communications · doi:10.1039/b409601k · Cited by 621 · see citing works
Cellular responses to hyperthermia (40–46 ° C): Cell killing and molecular events
Roti, J. L. R. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730701769841 · Cited by 574 · see citing works
Sonvico, F., Mornet, S., Vasseur, S., Dubernet, C., Jaillard, D., Degrouard, J., Hoebeke, J., Duguet, É., Colombo, P., & Couvreur, P. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050050z · Cited by 484 · see citing works
Figuerola, A., Di Corato, R., Manna, L., & Pellegrino, T. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.012 · Cited by 480 · see citing works
Self-citationKovalenko, M. V., Bodnarchuk, M. I., Lechner, R. T., et al. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0692478 · Cited by 420 · see citing works
Maghemite nanoparticles with very high AC-losses for application in RF-magnetic hyperthermia
Hergt, R., Hiergeist, R., Hilger, I., Kaiser, W. A., Lapatnikov, Y., Margel, S., & Richter, U. (2003) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2003.09.001 · Cited by 417 · see citing works
Effects of Magnetic Fluid Hyperthermia (MFH) on C3H mammary carcinomain vivo
Jordan, A., Scholz, R., Wust, P., Fähling, H., Krause, J., Wlodarczyk, W., Sander, B., Vogl, T., & FELIX, R. (1997) · International Journal of Hyperthermia · doi:10.3109/02656739709023559 · Cited by 325 · see citing works
Magnetic properties of bacterial magnetosomes as potential diagnostic and therapeutic tools
Hergt, R., Hiergeist, R., Zeisberger, M., Schüler, D., Heyen, U., Hilger, I., & Kaiser, W. A. (2005) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2005.01.047 · Cited by 324 · see citing works
Controlled Synthesis and Chemical Conversions of FeO Nanoparticles
Hou, Y., Xu, Z. J., & Sun, S. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200701694 · Cited by 322 · see citing works
Intracellular heating of living cells through Néel relaxation of magnetic nanoparticles
Fortin, J.-P., Gazeau, F., & Wilhelm, C. (2007) · European Biophysics Journal · doi:10.1007/s00249-007-0197-4 · Cited by 320 · see citing works
Self-citationSurfactant effects in magnetite nanoparticles of controlled size
Guardia, P., Batlle-Brugal, B., Roca, A. G., Iglesias, Ò., Morales, M. P., Serna, C. J., Labarta, A., & Batlle, X. (2007) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2007.03.085 · Cited by 309 · see citing works
Self-citationAlphandéry, E., Faure, S., Seksek, O., Guyot, F., & Chebbi, I. (2011) · ACS Nano · doi:10.1021/nn201290k · Cited by 306 · see citing works
Evaluation of iron-cobalt/ferrite core-shell nanoparticles for cancer thermotherapy
Habib, A. H., Ondeck, C. L., Chaudhary, P., et al. (2008) · Journal of Applied Physics · doi:10.1063/1.2830975 · Cited by 265 · see citing works
Lartigue, L., Innocenti, C., Thangavel, K., Awwad, A., Duque, M. D. M. S., Guari≠, Y., Larionova≠, J., Guérin, C., Montero, J., Barragan‐Montero, V., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja111448t · Cited by 260 · see citing works
Self-citationOptimizing Magnetic Nanoparticle Design for Nanothermotherapy
Gazeau, F., Lévy, M., & Wilhelm, C. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.831 · Cited by 256 · see citing works
Self-citationSafi, M., Courtois, J., Seigneuret, M., Conjeaud, H., & Berret, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.048 · Cited by 241 · see citing works
Direct Imaging of Zero-Field Dipolar Structures in Colloidal Dispersions of Synthetic Magnetite
Klokkenburg, M., Vonk, C., Claesson, E. M., et al. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0456252 · Cited by 217 · see citing works
Electrophoretic Separation of Nanoparticles with a Discrete Number of Functional Groups
Sperling, R. A., Pellegrino, T., Li, J., et al. (2006) · Advanced Functional Materials · doi:10.1002/adfm.200500589 · Cited by 209 · see citing works
Self-citationControlled Synthesis of Iron Oxide Nanoparticles over a Wide Size Range
Guardia, P., Pérez, N., Labarta, A., et al. (2009) · Langmuir · doi:10.1021/la903767e · Cited by 172 · see citing works
Self-citationUse of magnetic nanoparticle heating in the treatment of breast cancer
Hilger, I., Hergt, R., & Kaiser, W. A. (2005) · IEE Proceedings - Nanobiotechnology · doi:10.1049/ip-nbt:20055018 · Cited by 170 · see citing works
Bruns†, O. T., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Lauterwasser, J., Nikolić, M. S., Mollwitz†, B., Merkel, M., Bigall, N. C., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.405 · Cited by 165 · see citing works
Glöckl, G., Hergt, R., Zeisberger, M., Dutz, S., Nagel, S., & Weitschies, W. (2006) · Journal of Physics Condensed Matter · doi:10.1088/0953-8984/18/38/s27 · Cited by 158 · see citing works
Lévy, M., Quarta, A., Espinosa, A., Figuerola, A., Wilhelm, C., Garcı́a-Hernández, M., Genovese, A., Falqui, A., Alloyeau, D., Buonsanti, R., et al. (2011) · Chemistry of Materials · doi:10.1021/cm201078f · Cited by 150 · see citing works
Self-citationWater solubilization of hydrophobic nanocrystals by means of poly(maleic anhydride-alt-1-octadecene)
Corato, R. D., Quarta, A., Piacenza, P., Ragusa, A., Figuerola, A., Buonsanti, R., Cingolani, R., Manna, L., & Pellegrino, T. (2008) · Journal of Materials Chemistry · doi:10.1039/b717801h · Cited by 145 · see citing works
Self-citationHeating rate influence on the synthesis of iron oxide nanoparticles: the case of decanoic acid
Guardia, P., Pérez‐Juste, J., Labarta, A., et al. (2010) · Chemical Communications · doi:10.1039/c0cc01179g · Cited by 117 · see citing works
Self-citationLarge specific absorption rates in the magnetic hyperthermia properties of metallic iron nanocubes
Mehdaoui, B., Meffre, A., Lacroix, L., et al. (2010) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2010.05.012 · Cited by 117 · see citing works
Heat Production by Bacterial Magnetosomes Exposed to an Oscillating Magnetic Field
Alphandéry, E., Faure, S., Raison, L., et al. (2010) · The Journal of Physical Chemistry C · doi:10.1021/jp104580t · Cited by 111 · see citing works
The effects of magnetic nanoparticle properties on magnetic fluid hyperthermia
Kappiyoor, R., Liangruksa, M., Ganguly, R., et al. (2010) · Journal of Applied Physics · doi:10.1063/1.3500337 · Cited by 105 · see citing works
Cellular Level Loading and Heating of Superparamagnetic Iron Oxide Nanoparticles
Kalambur, V. S., Longmire, E. K., & Bischof, J. C. (2007) · Langmuir · doi:10.1021/la701100r · Cited by 101 · see citing works
Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia
Martinez-Boubeta, C., Balcells, L., Cristòfol, R. M., Sanfeliu, C., Rodrı́guez, E., Weissleder, R., Lope‐Piedrafita, S., Simeonidis, K., Angelakeris, M., Sandiumenge, F., et al. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.09.003 · Cited by 101 · see citing works
Accurate measurement of the specific absorption rate using a suitable adiabatic magnetothermal setup
Natividad, E., Castro, M. A., & Mediano, A. (2008) · Applied Physics Letters · doi:10.1063/1.2891084 · Cited by 82 · see citing works
Tumour Cell Toxicity of Intracellular Hyperthermia Mediated by Magnetic Nanoparticles
Wilhelm, C., Fortin, J.-P., & Gazeau, F. (2007) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2007.668 · Cited by 69 · see citing works
Self-citationTumour cell toxicity of intracellular hyperthermia mediated by magnetic nanoparticles
C.Fortin J.-P.Gazeau F., W. (2007) · Cited by 65 · see citing works
Stanford 3D hyperthermia treatment planning system. Technical review and clinical summary
Sullivan, D. M., Ben‐Yosef, R., & Kapp, D. S. (1993) · International Journal of Hyperthermia · doi:10.3109/02656739309032052 · Cited by 60 · see citing works
Reactivity of the monocyte/macrophage system to superparamagnetic anionic nanoparticles
Luciani, N., Gazeau, F., & Wilhelm, C. (2009) · Journal of Materials Chemistry · doi:10.1039/b903306h · Cited by 55 · see citing works
Self-citationPérez, N., Bartolomé, F., García, L. M., et al. (2009) · Applied Physics Letters · doi:10.1063/1.3095484 · Cited by 50 · see citing works
Liu, Y., Chen, Z., & Wang, J. (2010) · Journal of Nanoparticle Research · doi:10.1007/s11051-010-0019-y · Cited by 48 · see citing works
Huang, C., Neoh, K. G., Wang, L., et al. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm01526a · Cited by 40 · see citing works
Evaluation of the Sigma 60 applicator for regional hyperthermia in terms of scattering parameters
Leybovicht, L. B., Myerson, R. J., Emami, B., et al. (1991) · International Journal of Hyperthermia · doi:10.3109/02656739109056459 · Cited by 24 · see citing works
Franconi, C., Vrba, J., Micali, F., et al. (2011) · International Journal of Hyperthermia · doi:10.3109/02656736.2010.521886 · Cited by 12 · see citing works
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- Authors
- Guardia, P., Di Corato, R., Lartigue, L., Wilhelm, C., Espinosa, A., Garcia-Hernandez, M., Gazeau, F., Manna, L., & Pellegrino, T.
- Affiliations
- Italian Institute of Technology (IT)
- Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy
- Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, CNRS and Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France
- Centre National de la Recherche Scientifique (FR)
- Consejo Superior de Investigaciones Científicas (ES)
- Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Científicas, Cantoblanco, 28049 Madrid, Spain
- Corresponding author
- Pellegrino, Teresa
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-11
- Volume
- 6
- Issue
- 4
- Pages
- 3080-3091
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2065674352
- Cited by
- 752
- References
- 58
- Citations by year
- 2026: 30 · 2025: 35 · 2024: 40 · 2023: 42 · 2022: 65 · 2021: 74 · 2020: 71 · 2019: 74 · 2018: 57 · 2017: 69 · 2016: 57 · 2015: 58 · 2014: 31 · 2013: 37 · 2012: 11
- FWCI
- 24.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- iron oxide nanocrystals, specific absorption rate, magnetic hyperthermia, one-pot synthesis, nanocrystal size effects
- MeSH terms
- Absorption, Cell Survival, Ferric Compounds, Humans, Hyperthermia, Induced, KB Cells, Neoplasms, Safety, Solubility, Temperature, Water, Nanotechnology, Nanostructures, Magnetic Phenomena
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