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In vivo Cellular Uptake, Degradation, and Biocompatibility of Polyelectrolyte Microcapsules
Abstract
Polyelectrolyte microcapsules are made by layer‐by‐layer (LbL) coating of a sacrificial template, followed by decomposition of the template, to produce hollow microcapsules. In this paper, we report on the in vivo cellular uptake, degradation and biocompatibility of polyelectrolyte microcapsules produced from alternating dextran sulphate and poly‐L‐arginine layers on a template of calcium carbonate microparticles. We show that a moderate tissue reaction is observed after subcutaneous injection of polyelectrolyte microcapsules in mice. Within sixteen days after subcutaneous injection, most of the microcapsules are internalized by the cells and start to get degraded. The number of polyelectrolyte layers determines the stability of the microcapsules after cellular uptake.
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Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
Cited by
Layer-by-Layer Nanoparticles with a pH-Sheddable Layer for in Vivo Targeting of Tumor Hypoxia
Poon, Z., Chang, D., Zhao, X., & Hammond, P. T. (2011) · ACS Nano · doi:10.1021/nn200876f · Cited by 343
The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald
Zhao, S., Caruso, F., Dähne, L., Decher, G., De Geest, B. G., Fan, J., Feliu, N., Gogotsi, Y., Hammond, P. T., Hersam, M. C., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b03326 · Cited by 283
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Metadata
- Authors
- De Koker, S., De Geest, B. G., Cuvelier, C., Ferdinande, L., Deckers, W., Hennink, W. E., De Smedt, S. C., & Mertens, N.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2007-11-28
- Volume
- 17
- Issue
- 18
- Pages
- 3754-3763
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2165210975
- Cited by
- 223
- References
- 2
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Koker, S., De Geest, B. G., Cuvelier, C., Ferdinande, L., Deckers, W., Hennink, W. E., De Smedt, S. C., & Mertens, N. (2007). In vivo Cellular Uptake, Degradation, and Biocompatibility of Polyelectrolyte Microcapsules. Advanced Functional Materials. https://doi.org/10.1002/adfm.200700416
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