The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Polymer Scaffolds for Small‐Diameter Vascular Tissue Engineering
Open accessAbstract
To better engineer small‐diameter blood vessels, a few types of novel scaffolds are fabricated from biodegradable poly(L‐lactic acid) (PLLA) by means of thermally induced phase‐separation (TIPS) techniques. By utilizing the differences in thermal conductivities of the mold materials and using benzene as the solvent scaffolds with oriented gradient microtubular structures in the axial or radial direction can be created. The porosity, tubular size, and the orientational direction of the microtubules can be controlled by the polymer concentration, the TIPS temperature, and by utilizing materials of different thermal conductivities. These gradient microtubular structures facilitate cell seeding and mass transfer for cell growth and function. Nanofibrous scaffolds with an oriented and interconnected microtubular pore network are also developed by a one‐step TIPS method using a benzene/tetrahydrofuran mixture as the solvent without the need for porogen materials. The structural features of such scaffolds can be conveniently adjusted by varying the solvent ratio, phase‐separation temperature, and polymer concentration to mimic the nanofibrous features of an extracellular matrix. These scaffolds were fabricated for the tissue engineering of small‐diameter blood vessels by utilizing their advantageous structural features to facilitate blood‐vessel regeneration.
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Metadata
- Authors
- Ma, H., Hu, J., & Ma, P. X.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Ma, Peter X.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2010-09-08
- Volume
- 20
- Issue
- 17
- Pages
- 2833-2841
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- PMC
- PMC3911792
- OpenAlex
- W2113364032
- Cited by
- 122
- References
- 45
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 6 · 2022: 10 · 2021: 5 · 2020: 14 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 12 · 2013: 8 · 2012: 6
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advanced Functional Materials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01DE017689, R01DE015384, DE 015384)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- polymer scaffolds, poly(L-lactic acid), thermally induced phase separation, nanofibrous scaffolds, porosity control, extracellular matrix mimicry, vascular regeneration, cell seeding
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