Fabrication of Biomedical Scaffolds Using Biodegradable Polymers.
Abstract
Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities in additive manufacturing coupled with advances in orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-specific form factors and strategies for designing and creating bioactive scaffolds. However, these defect-specific scaffolds, especially when utilizing degradable polymers as the base material, present processing challenges that are distinct and unique from other classes of materials. The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.
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3D printing technologies can accurately and quickly fabricate scaffolds with precise geometry and high pore connectivity, similar to native tissues.
“it can accurately and quickly fabricate scaffolds with precise geometry and high pore connectivity, similar to native tissues [13][14][15][16][17]”
From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [15]
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- Authors
- Kirillova, A., Yeazel, T. R., Asheghali, D., Petersen, S. R., Dort, S., Gall, K., & Becker, M. L.
- Affiliations
- Duke University (US)
- Corresponding author
- Becker, Matthew L.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-04-15
- Volume
- 121
- Issue
- 18
- Pages
- 11238-11304
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3155020406
- Cited by
- 368
- References
- 459
- Citations by year
- 2026: 66 · 2025: 96 · 2024: 95 · 2023: 57 · 2022: 44 · 2021: 10
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Division of Materials Research (1507420)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- biodegradable polymers, biomedical scaffolds, scaffold fabrication, tissue engineering, additive manufacturing, chemical functionalization, regenerative medicine, scaffold design
- MeSH terms
- Biocompatible Materials, Polymers, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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