Substrates for cardiovascular tissue engineering
Abstract
Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of heart valves, arteries and myocardium by creating 'living' tissue replacements outside (in vitro) or inside (in situ) the human body. A combination of cells, biomaterials and environmental cues of tissue development is employed to obtain tissues with targeted structure and functional properties that can survive and develop within the harsh hemodynamic environment of the cardiovascular system. This paper reviews the up-to-date status of cardiovascular tissue engineering with special emphasis on the development and use of biomaterial substrates. Key requirements and properties of these substrates, as well as methods and readout parameters to test their efficacy in the human body, are described in detail and discussed in the light of current trends toward designing biologically inspired microenviroments for in situ tissue engineering purposes.
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Imparting anti-thrombogenic and anti-calcification properties is crucial for artificial heart valves, capabilities that PLCL inherently lacks.
“imparting anti-thrombogenic and anti-calcification properties is crucial for artificial heart valves, capabilities that PLCL inherently lacks, and PLCL itself does not have these capabilities [170].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [170]
Valve surface needs to withstand continuous impact of blood flow, making it prone to deposits such as calcification and thrombosis.
“the valve surface needs to withstand the continuous impact of blood flow, making it prone to deposits such as calcification and thrombosis.”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [170]
Cites
1 retracted
Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
Lee, H. C., Kim, S., Kim, K., Shin, H., & Yoon, J. (2000) · Nature · doi:10.1038/35044106 · Cited by 432 · see citing works
RetractedMatrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136 · see citing works
New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E. I., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,893 · see citing works
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864 · see citing works
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551 · see citing works
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works
Fabrication of novel biomaterials through molecular self-assembly
Zhang, S. (2003) · Nature Biotechnology · doi:10.1038/nbt874 · Cited by 3,353 · see citing works
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650 · see citing works
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607 · see citing works
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
Hersel, U., Dahmen, C., & Kessler, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00343-0 · Cited by 2,590 · see citing works
Reversible Polymers Formed from Self-Complementary Monomers Using Quadruple Hydrogen Bonding
Sijbesma, R. P., Beijer, F. H., Brunsveld, L., Folmer, B. J. B., Hirschberg, J. H. K. K., Lange, R. F. M., Lowe, J. K. L., & Meijer, E. W. (1997) · Science · doi:10.1126/science.278.5343.1601 · Cited by 2,396 · see citing works
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
Silva, G. A., Czeisler, C. M., Niece, K. L., Beniash, E., Harrington, D. A., Kessler, J. A., & Stupp, S. I. (2004) · Science · doi:10.1126/science.1093783 · Cited by 2,169 · see citing works
Yarbrough, W. M., Robbins, R. C., & Mallidi, H. R. (2016) · CRC Press eBooks · doi:10.3109/9781439802571-25 · Cited by 2,161 · see citing works
Functional Arteries Grown in Vitro
Niklason, L. E., Gao, J., Abbott, W. M., Hirschi, K. K., Houser, S. L., Marini, R. P., & Langer, R. (1999) · Science · doi:10.1126/science.284.5413.489 · Cited by 1,767 · see citing works
Polymeric system for dual growth factor delivery
Richardson, T. P., Peters, M. C., Ennett, A. B., & Mooney, D. J. (2001) · Nature Biotechnology · doi:10.1038/nbt1101-1029 · Cited by 1,753 · see citing works
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748 · see citing works
Complexity in biomaterials for tissue engineering
Place, E., Evans, N. D., & Stevens, M. M. (2009) · Nature Materials · doi:10.1038/nmat2441 · Cited by 1,735 · see citing works
Self‐assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials
Cui, H., Webber, M. J., & Stupp, S. I. (2010) · Biopolymers · doi:10.1002/bip.21328 · Cited by 1,548 · see citing works
Designing materials to direct stem-cell fate
Lütolf, M. P., Gilbert, P. M., & Blau, H. M. (2009) · Nature · doi:10.1038/nature08602 · Cited by 1,389 · see citing works
Vacanti, J. P., & Langer, R. (1999) · The Lancet · doi:10.1016/s0140-6736(99)90247-7 · Cited by 1,322 · see citing works
Spinale, F. G. (2007) · Physiological Reviews · doi:10.1152/physrev.00012.2007 · Cited by 1,109 · see citing works
Human tissue-engineered blood vessels for adult arterial revascularization
L’Heureux, N., Dusserre, N., König, G., Victor, B. E., Keire, P. A., Wight, T. N., Chronos, N. A. F., Kyles, A. E., Gregory, C. R., Hoyt, G. E., et al. (2006) · Nature Medicine · doi:10.1038/nm1364 · Cited by 1,083 · see citing works
Vascular Extracellular Matrix and Arterial Mechanics
Wagenseil, J. E., & Mecham, R. P. (2009) · Physiological Reviews · doi:10.1152/physrev.00041.2008 · Cited by 1,061 · see citing works
Cardiac interstitium in health and disease: The fibrillar collagen network
Weber, K. T. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90360-4 · Cited by 1,060 · see citing works
Cell and molecular mechanics of biological materials
Bao, G., & Suresh, S. (2003) · Nature Materials · doi:10.1038/nmat1001 · Cited by 1,058 · see citing works
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Zimmermann, W., Melnychenko, I., Wasmeier, G. H., Didié, M., Naito, H., Nixdorff, U., Heß, A., Budinský, L., Brune, K., Michaelis, B., et al. (2006) · Nature Medicine · doi:10.1038/nm1394 · Cited by 996 · see citing works
REPLACEMENT OF AORTIC AND MITRAL VALVES WITH A PULMONARY AUTOGRAFT
Ross, D. N. (1967) · The Lancet · doi:10.1016/s0140-6736(67)90794-5 · Cited by 981 · see citing works
Cell adhesion and motility depend on nanoscale RGD clustering
Maheshwari, G., Brown, G., Lauffenburger, D. A., Wells, A. H., & Griffith, L. G. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.10.1677 · Cited by 951 · see citing works
Tissue Engineering of a Differentiated Cardiac Muscle Construct
Zimmermann, W.-H., Schneiderbanger, K., Schubert, P., Didié, M., Münzel, F., Heubach, J. F., Kostin, S., Neuhuber, W. L., & Eschenhagen, T. (2002) · Circulation Research · doi:10.1161/hh0202.103644 · Cited by 917 · see citing works
Radisic, M., Park, H., Shing, H., Consi, T. R., Schöen, F. J., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407817101 · Cited by 913 · see citing works
Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell
Chien, S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01047.2006 · Cited by 912 · see citing works
Engler, A. J., Krieger, C. C., Johnson, C. P., Raab, M., Tang, H., Speicher, D. W., Sanger, J. W., Sanger, J. M., & Discher, D. E. (2008) · Journal of Cell Science · doi:10.1242/jcs.029678 · Cited by 869 · see citing works
Inspiration and application in the evolution of biomaterials
Huebsch, N., & Mooney, D. J. (2009) · Nature · doi:10.1038/nature08601 · Cited by 858 · see citing works
Accordion-like honeycombs for tissue engineering of cardiac anisotropy
Engelmayr, G. C., Cheng, M., Bettinger, C. J., Borenstein, J. T., Langer, R., & Freed, L. E. (2008) · Nature Materials · doi:10.1038/nmat2316 · Cited by 848 · see citing works
Synthetic polymer scaffolds for tissue engineering
Place, E., George, J. H., Williams, C. K., & Stevens, M. M. (2009) · Chemical Society Reviews · doi:10.1039/b811392k · Cited by 820 · see citing works
A CONSTRAINED MIXTURE MODEL FOR GROWTH AND REMODELING OF SOFT TISSUES
Humphrey, J. D., & Rajagopal, K. R. (2002) · Mathematical Models and Methods in Applied Sciences · doi:10.1142/s0218202502001714 · Cited by 768 · see citing works
Mechanically Activated Integrin Switch Controls α 5 β 1 Function
Friedland, J. C., Lee, M. H., & Boettiger, D. E. (2009) · Science · doi:10.1126/science.1168441 · Cited by 717 · see citing works
In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction
Kraitchman, D. L., Heldman, A. W., Atalar, E., Amado, L. C., Martin, B. J., Pittenger, M. F., Hare, J. M., & Bulte, J. W. M. (2003) · Circulation · doi:10.1161/01.cir.0000070931.62772.4e · Cited by 706 · see citing works
Guan, J., Fujimoto, K. L., Sacks, M. S., & Wagner, W. R. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.018 · Cited by 705 · see citing works
Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells
Zhou, M., Smith, A. M., Das, A. K., Hodson, N. W., Collins, R. F., Ulijn, R. V., & Gough, J. E. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.010 · Cited by 673 · see citing works
Cell sheet engineering for myocardial tissue reconstruction
Shimizu, T., Yamato, M., Kikuchi, A., & Okano, T. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00110-8 · Cited by 672 · see citing works
Molecular self-assembly and applications of designer peptide amphiphiles
Zhao, X., Pan, F., Xu, H., Yaseen, M., Shan, H., Hauser, C. A. E., Zhang, S., & Lu, J. R. (2010) · Chemical Society Reviews · doi:10.1039/b915923c · Cited by 668 · see citing works
Proangiogenic scaffolds as functional templates for cardiac tissue engineering
Madden, L. R., Mortisen, D. J., Sussman, E. M., Dupras, S. K., Fugate, J. A., Cuy, J. L., Hauch, K. D., Laflamme, M. A., Murry, C. E., & Ratner, B. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006442107 · Cited by 662 · see citing works
Ultrasound-Stimulated Vibro-Acoustic Spectrography
Fatemi, M., & Greenleaf, J. F. (1998) · Science · doi:10.1126/science.280.5360.82 · Cited by 648 · see citing works
Haines-Butterick, L. A., Rajagopal, K., Branco, M. C., Salick, D. A., Rughani, R. V., Pilarz, M., Lamm, M. S., Pochan, D. J., & Schneider, J. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701980104 · Cited by 644 · see citing works
Eschenhagen, T., Fink, C., Remmers, U., Scholz, H., Wattchow, J., Weil, J., Zimmermann, W., Dohmen, H. H., Schäfer, H., Bishopric, N., et al. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.8.9240969 · Cited by 636 · see citing works
Transplantation of a Tissue-Engineered Pulmonary Artery
Shinoka, T., Imai, Y., & Ikada, Y. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102153440717 · Cited by 634 · see citing works
Early failure of the tissue engineered porcine heart valve SYNERGRAFT™ in pediatric patients
Simon, P. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(03)00094-0 · Cited by 623 · see citing works
In vivo imaging platform for tracking immunotherapeutic cells
Ahrens, E. T., Flores, R. R., Xu, H., & Morel, P. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1121 · Cited by 620 · see citing works
Self-Assembly of Large and Small Molecules into Hierarchically Ordered Sacs and Membranes
Capito, R. M., Azevedo, H. S., Velichko, Y., Mata, Á., & Stupp, S. I. (2008) · Science · doi:10.1126/science.1154586 · Cited by 601 · see citing works
Functional Living Trileaflet Heart Valves Grown In Vitro
Hoerstrup, S. P., Sodian, R., Daebritz, S. H., et al. (2000) · Circulation · doi:10.1161/01.cir.102.suppl_3.iii-44 · Cited by 595 · see citing works
Structure and Function of Basement Membranes
LeBleu, V. S., MacDonald, B. A., & Kalluri, R. K. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-mr-72 · Cited by 594 · see citing works
Mechanisms of Myofibroblast Activity and Phenotypic Modulation
Serini, G., & Gabbiani, G. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4543 · Cited by 592 · see citing works
Shinoka, T., Matsumura, G., Hibino, N., Naito, Y., Watanabe, M., Konuma, T., Sakamoto, T., Nagatsu, M., & Kurosawa, H. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.12.047 · Cited by 586 · see citing works
Davis, M. E., Motion, J. P. M., Narmoneva, D. A., Takahashi, T., Hakuno, D., Kamm, R. D., Zhang, S., & Lee, R. T. (2005) · Circulation · doi:10.1161/01.cir.0000153847.47301.80 · Cited by 575 · see citing works
Roh, J. D., Sawh-Martinez, R., Brennan, M. P., Jay, S. M., Devine, L., Rao, D. A., Yi, T., Mirensky, T. L., Nalbandian, A., Udelsman, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911465107 · Cited by 559 · see citing works
Bioengineered Cardiac Grafts : A New Approach to Repair the Infarcted Myocardium?
Leor, J., Etzion, S., Dar, A., Shapiro, L., Barbash, I. M., Battler, A., Granot, Y., & Cohen, S. (2000) · Circulation · doi:10.1161/01.cir.102.suppl_3.iii-56 · Cited by 559 · see citing works
Dynamic Mechanical Conditioning of Collagen-Gel Blood Vessel Constructs Induces Remodeling In Vitro
Seliktar, D., Black, R. A., Vito, R. P., & Nerem, R. M. (2000) · Annals of Biomedical Engineering · doi:10.1114/1.275 · Cited by 555 · see citing works
Patterson, J., & Hubbell, J. A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.06.061 · Cited by 536 · see citing works
Chen, Q.-Z., Bismarck, A., Hansen, U., Junaid, S., Tran, M. Q., Harding, S. E., Ali, N. N., & Boccaccini, A. R. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.09.010 · Cited by 531 · see citing works
Challenges in Cardiac Tissue Engineering
Vunjak-Novakovic, G., Tandon, N., Godier, A. F. G., Maidhof, R., Marsano, A., Martens, T., & Radišić, M. (2009) · Tissue engineering. Part B, Reviews · doi:10.1089/ten.teb.2009.0352 · Cited by 521 · see citing works
Late-term results of tissue-engineered vascular grafts in humans
Hibino, N., McGillicuddy, E., Matsumura, G., et al. (2010) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2009.09.057 · Cited by 521 · see citing works
Elastin as a biomaterial for tissue engineering
Daamen, W. F., Veerkamp, J. H., van Hest, J. C. M., & van Kuppevelt, T. H. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.025 · Cited by 519 · see citing works
Bonnar, J., & Denson, K. W. E. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91163-5 · Cited by 519 · see citing works
Development of a drug screening platform based on engineered heart tissue
Hansen, A., Eder, A., Bönstrup, M., Flato, M., Mewe, M., Schaaf, S., Aksehirlioglu, B., Schwörer, A., Uebeler, J., & Eschenhagen, T. (2010) · Circulation Research · doi:10.1161/circresaha.109.211458 · Cited by 510 · see citing works
Gene Expression in Fibroblasts and Fibrosis
Manabe, I., Shindo, T., & Nagai, R. (2002) · Circulation Research · doi:10.1161/01.res.0000046452.67724.b8 · Cited by 508 · see citing works
Controlled growth factor release from synthetic extracellular matrices
Lee, K. Y., Peters, M. C., Anderson, K. W., & Mooney, D. J. (2000) · Nature · doi:10.1038/35050141 · Cited by 506 · see citing works
Electrospun nanofibrous materials for tissue engineering and drug delivery
Cui, W., Zhou, Y., & Chang, J. (2010) · Science and Technology of Advanced Materials · doi:10.1088/1468-6996/11/1/014108 · Cited by 493 · see citing works
Cyclic mechanical strain regulates the development of engineered smooth muscle tissue
Kim, B., Nikolovski, J., Bonadio, J. F., et al. (1999) · Nature Biotechnology · doi:10.1038/13671 · Cited by 492 · see citing works
Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe
Mulder, W. J. M., Koole, R., Brandwijk, R. J. M. G. E., Storm, G., Chin, P. T. K., Strijkers, G. J., Donegá, C. D. M., Nicolay, K., & Griffioen, A. W. (2005) · Nano Letters · doi:10.1021/nl051935m · Cited by 484 · see citing works
Medical applications of membranes: Drug delivery, artificial organs and tissue engineering
Stamatialis, D. F., Papenburg, B. J., Gironés, M., Saiful, S., Bettahalli, S. N. M., Schmitmeier, S., & Wessling, M. (2008) · Journal of Membrane Science · doi:10.1016/j.memsci.2007.09.059 · Cited by 473 · see citing works
Polymer Scaffolds for Biomaterials Applications
Shoichet, M. S. (2009) · Macromolecules · doi:10.1021/ma901530r · Cited by 469 · see citing works
Enzyme-responsive materials: a new class of smart biomaterials
Ulijn, R. V. (2006) · Journal of Materials Chemistry · doi:10.1039/b601776m · Cited by 468 · see citing works
Vaz, C. M., van Tuijl, S., Bouten, C. V. C., & Baaijens, F. P. T. (2005) · Acta Biomaterialia · doi:10.1016/j.actbio.2005.06.006 · Cited by 459 · see citing works
Self-citationA modular and supramolecular approach to bioactive scaffolds for tissue engineering
Dankers, P. Y. W., Harmsen, M. C., Brouwer, L. A., van Luyn, M. J. A., & Meijer, E. W. (2005) · Nature Materials · doi:10.1038/nmat1418 · Cited by 454 · see citing works
Self-citationLanda, N., Miller, L., Feinberg, M. S., Holbová, R., Shachar, M., Freeman, I., Cohen, S., & Leor, J. (2008) · Circulation · doi:10.1161/circulationaha.107.727420 · Cited by 449 · see citing works
Human Semilunar Cardiac Valve Remodeling by Activated Cells From Fetus to Adult
Aikawa, E. R., Whittaker, P., Farber, M., Mendelson, K., Padera, R. F., Aikawa, M., & Schöen, F. J. (2006) · Circulation · doi:10.1161/circulationaha.105.591768 · Cited by 427 · see citing works
Schoen, F. J. (2008) · Circulation · doi:10.1161/circulationaha.108.805911 · Cited by 421 · see citing works
Cooperative effects of Rho and mechanical stretch on stress fiber organization
Kaunas, R. R., Nguyen, P., Usami, S., & Chien, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506041102 · Cited by 418 · see citing works
Christman, K. L., Fok, H. H., Sievers, R. E., Fang, Q., & Lee, R. J. (2004) · Tissue Engineering · doi:10.1089/107632704323061762 · Cited by 418 · see citing works
Design and analysis of tissue engineering scaffolds that mimic soft tissue mechanical anisotropy
Courtney, T. D., Sacks, M. S., Stankus, J. J., Guan, J., & Wagner, W. R. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.024 · Cited by 414 · see citing works
Heparin Binding Nanostructures to Promote Growth of Blood Vessels
Rajangam, K. L., Behanna, H. A., Hui, M. J., Han, X., Hulvat, J. F., Lomasney, J. W., & Stupp, S. I. (2006) · Nano Letters · doi:10.1021/nl0613555 · Cited by 413 · see citing works
In situ elasticity modulation with dynamic substrates to direct cell phenotype
Kloxin, A. M., Benton, J. A., & Anseth, K. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.025 · Cited by 405 · see citing works
Biomaterials for the Treatment of Myocardial Infarction
Christman, K. L., & Lee, R. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.005 · Cited by 404 · see citing works
Biomaterials for Vascular Tissue Engineering
Ravi, S., & Chaikof, E. L. (2009) · Regenerative Medicine · doi:10.2217/rme.09.77 · Cited by 389 · see citing works
Life and Death of Cardiac Stem Cells
Anversa, P., Kajstura, J., Leri, A., & Bolli, R. (2006) · Circulation · doi:10.1161/circulationaha.105.595181 · Cited by 385 · see citing works
Materials as morphogenetic guides in tissue engineering
Hubbell, J. A. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.09.004 · Cited by 380 · see citing works
Combining supramolecular chemistry with biology
Uhlenheuer, D. A., Petkau‐Milroy, K., & Brunsveld, L. (2010) · Chemical Society Reviews · doi:10.1039/b820283b · Cited by 378 · see citing works
On the biomechanics of heart valve function
Sacks, M. S., Merryman, W. D., & Schmidt, D. E. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.05.015 · Cited by 377 · see citing works
Transplantation of cells in matrices for tissue regeneration
Marler, J. J., Upton, J. M., Langer, R., & Vacanti, J. P. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00025-8 · Cited by 377 · see citing works
Designer self-assembling peptide nanofiber biological materials
Hauser, C. A. E., & Zhang, S. (2010) · Chemical Society Reviews · doi:10.1039/b921448h · Cited by 371 · see citing works
Cardiac muscle tissue engineering: toward an in vitro model for electrophysiological studies
Bursac, N., Papadaki, M., Cohen, R. J., Schöen, F. J., Eisenberg, S. R., Carrier, R. L., Vunjak‐Novakovic, G., & Freed, L. E. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h433 · Cited by 366 · see citing works
Barocas, V. H., & Tranquillo, R. T. (1997) · Journal of Biomechanical Engineering · doi:10.1115/1.2796072 · Cited by 360 · see citing works
Li, M., Mondrinos, M. J., Chen, X., Gandhi, M., Ko, F., & Lelkes, P. I. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30833 · Cited by 359 · see citing works
Contractile cardiac grafts using a novel nanofibrous mesh
Shin, M., Ishii, O., Sueda, T., & Vacanti, J. P. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.10.055 · Cited by 359 · see citing works
Pektok, E., Nottelet, B., Tille, J., Gurny, R., Kalangos, A., Moeller, M., & Walpoth, B. H. (2008) · Circulation · doi:10.1161/circulationaha.108.795732 · Cited by 358 · see citing works
Hsieh, P. C. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25878 · Cited by 357 · see citing works
Dimensions and Geometric Relationships of the Human Aortic Value as a Function of Pressure
SWANSON, W. M., & Clark, R. E. (1974) · Circulation Research · doi:10.1161/01.res.35.6.871 · Cited by 351 · see citing works
Biofunctionalization of Biomaterials for Accelerated in Situ Endothelialization: A Review
de Mel, A., Jell, G., Stevens, M. M., & Seifalian, A. M. (2008) · Biomacromolecules · doi:10.1021/bm800681k · Cited by 349 · see citing works
Leor, J., Tuvia, S., Guetta, V., Manczur, F., Castel, D., Willenz, U., Petneházy, Ö., Landa, N., Feinberg, M. S., Konen, E., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.06.010 · Cited by 347 · see citing works
Cells, scaffolds, and molecules for myocardial tissue engineering
Leor, J., Amsalem, Y., & Cohen, S. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.10.003 · Cited by 342 · see citing works
Galler, K. M., Aulisa, L., Regan, K. R., D’Souza, R. N., & Hartgerink, J. D. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910481t · Cited by 339 · see citing works
Medium perfusion enables engineering of compact and contractile cardiac tissue
Radisic, M., Yang, L., Boublik, J., Cohen, R. J., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00171.2003 · Cited by 334 · see citing works
Early In Vivo Experience With Tissue-Engineered Trileaflet Heart Valves
Sodian, R., HOERSTRUP, S., Sperling, J. S., et al. (2000) · Circulation · doi:10.1161/01.cir.102.suppl_3.iii-22 · Cited by 330 · see citing works
Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges
Mendelson, K., & Schöen, F. J. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9163-z · Cited by 329 · see citing works
Biomimetic Approach to Cardiac Tissue Engineering: Oxygen Carriers and Channeled Scaffolds
Radisic, M., Park, H., Chen, F., Salazar-Lazzaro, J. E., Wang, Y., Dennis, R. G., Langer, R., Freed, L. E., & Vunjak‐Novakovic, G. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.2077 · Cited by 325 · see citing works
Synthetic Materials in the Study of Cell Response to Substrate Rigidity
Nemir, S., & West, J. L. (2010) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9811-1 · Cited by 318 · see citing works
Cummings, C. L., Gawlitta, D., Nerem, R. M., et al. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.10.073 · Cited by 312 · see citing works
Genové, E., Shen, C. J., Zhang, S., & Semino, C. E. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.08.012 · Cited by 310 · see citing works
Oxygen generating scaffolds for enhancing engineered tissue survival
Oh, S. H., Ward, C. L., Atala, A., Yoo, J. J., & Harrison, B. S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.065 · Cited by 308 · see citing works
Theoretical Impact of the Injection of Material Into the Myocardium
Wall, S., Walker, J. C., Healy, K. E., Ratcliffe, M. B., & Guccione, J. M. (2006) · Circulation · doi:10.1161/circulationaha.106.657270 · Cited by 308 · see citing works
New materials for tissue engineering: towards greater control over the biological response
Chan, G., & Mooney, D. J. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.03.011 · Cited by 307 · see citing works
Boccaccini, A. R. (2003) · Composites Science and Technology · doi:10.1016/s0266-3538(03)00275-6 · Cited by 304 · see citing works
Chiu, L. L. Y., & Radisic, M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.039 · Cited by 302 · see citing works
Zelzer, M., & Ulijn, R. V. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00035c · Cited by 302 · see citing works
Optimizing Engineered Heart Tissue for Therapeutic Applications as Surrogate Heart Muscle
Naito, H., Melnychenko, I., Didié, M., Schneiderbanger, K., Schubert, P., Rosenkranz, S., Thomas Eschenhagen, A., & Zimmermann, W. (2006) · Circulation · doi:10.1161/circulationaha.105.001560 · Cited by 301 · see citing works
Development of bioactive peptide amphiphiles for therapeutic cell delivery
Webber, M. J., Tongers, J., Renault, M., Roncalli, J. G., Losordo, D. W., & Stupp, S. I. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.07.031 · Cited by 297 · see citing works
From Stem Cells to Viable Autologous Semilunar Heart Valve
Sutherland, F. W. H., Perry, T. E., Yu, Y., Sherwood, M. C., Aikawa, E. R., Masuda, Y., Garcia, G. A., McLellan, D. L., Engelmayr, G. C., Sacks, M. S., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.498378 · Cited by 297 · see citing works
Ifkovits, J. L., Tous, E., Minakawa, M., Morita, M., Robb, J. D., Koomalsingh, K. J., Gorman, J. H., Gorman, R. C., & Burdick, J. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004097107 · Cited by 296 · see citing works
MMP‐2 sensitive, VEGF‐bearing bioactive hydrogels for promotion of vascular healing
Seliktar, D., Zisch, A. H., Lütolf, M. P., Wrana, J. L., & Hubbell, J. A. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.20091 · Cited by 295 · see citing works
Christiansen, D. L., Huang, E. K., & Silver, F. H. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00089-5 · Cited by 293 · see citing works
Engineered heart tissue for regeneration of diseased hearts
Zimmermann, W., Melnychenko, I., & Thomas Eschenhagen, A. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00521-0 · Cited by 291 · see citing works
Advanced Tools for Tissue Engineering: Scaffolds, Bioreactors, and Signaling
Freed, L. E., Guilak, F., Guo, X. E., Gray, M. L., Tranquillo, R. T., Holmes, J. W., Radisic, M., Sefton, M. V., Kaplan, D. L., & Vunjak‐Novakovic, G. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.3285 · Cited by 284 · see citing works
Engineering of fibrin-based functional and implantable small-diameter blood vessels
Swartz, D. D., Russell, J. A., & Andreadis, S. T. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00479.2004 · Cited by 277 · see citing works
Successful application of tissue engineered vascular autografts: clinical experience
Matsumura, G., Hibino, N., Ikada, Y., Kurosawa, H., & Shinoka, T. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00043-7 · Cited by 276 · see citing works
Bioartificial matrices for therapeutic vascularization
Phelps, E. A., Landázuri, N., Thulé, P. M., Taylor, W. R., & Garcı́a, A. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905447107 · Cited by 274 · see citing works
Cardiac tissue engineering using perfusion bioreactor systems
Radisic, M., Marsano, A., Maidhof, R., Wang, Y., & Vunjak‐Novakovic, G. (2008) · Nature Protocols · doi:10.1038/nprot.2008.40 · Cited by 273 · see citing works
Radisic, M., Deen, W. M., Langer, R., & Vunjak‐Novakovic, G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00787.2004 · Cited by 269 · see citing works
Zaari, N., Rajagopalan, P., Kim, S. K., Engler, A. J., & Wong, J. Y. (2004) · Advanced Materials · doi:10.1002/adma.200400883 · Cited by 268 · see citing works
Myocardial tissue engineering: a review
Jawad, H., Ali, N. N., Lyon, A. R., Chen, Q. Z., Harding, S. E., & Boccaccini, A. R. (2007) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.46 · Cited by 263 · see citing works
Li, T., Cheng, K., Lee, S.-T., Matsushita, S., Davis, D. R., Malliaras, K. G., Zhang, Y., Matsushita, N., Smith, R. R., & Marbán, E. (2010) · Stem Cells · doi:10.1002/stem.532 · Cited by 262 · see citing works
Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways
Viola Vogel, B., & Sheetz, M. P. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.002 · Cited by 261 · see citing works
Thickening of the Infarcted Wall by Collagen Injection Improves Left Ventricular Function in Rats
Dai, W., Wold, L. E., Dow, J., & Kloner, R. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.056 · Cited by 260 · see citing works
Bioengineering Challenges for Heart Valve Tissue Engineering
Sacks, M. S., Schoen, F. J., & Mayer, J. E. (2009) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-061008-124903 · Cited by 257 · see citing works
Pêgo, A. P., van Luyn, M. J. A., Brouwer, L., van Wachem, P. B., Poot, A. A., Grijpma, D. W., & Feijen, J. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10121 · Cited by 257 · see citing works
Syedain, Z. H., Meier, L. A., Bjork, J. W., Lee, A., & Tranquillo, R. T. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.019 · Cited by 253 · see citing works
An Enhanced CVD Approach to Extensive Nanotube Networks with Directionality
Franklin, N., & Dai, H. (2000) · Advanced Materials · doi:10.1002/1521-4095(200006)12:12 · Cited by 249 · see citing works
Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine
Chien, K. R., Domian, I. J., & Parker, K. K. (2008) · Science · doi:10.1126/science.1163267 · Cited by 246 · see citing works
Effects of VEGF temporal and spatial presentation on angiogenesis
Silva, E. A., & Mooney, D. J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.052 · Cited by 246 · see citing works
Fujimoto, K. L., Tobita, K., Merryman, W. D., Guan, J., Momoi, N., Stolz, D. B., Sacks, M. S., Keller, B. B., & Wagner, W. R. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.050 · Cited by 236 · see citing works
Custom Design of the Cardiac Microenvironment With Biomaterials
Davis, M. E., Hsieh, P. C. H., Grodzinsky, A. J., & Lee, R. T. (2005) · Circulation Research · doi:10.1161/01.res.0000173376.39447.01 · Cited by 234 · see citing works
More than just bare scaffolds: towards multi-component and decorated fibrous biomaterials
Woolfson, D. N., & Mahmoud, Z. N. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00032a · Cited by 233 · see citing works
Arts, T. G. J., Bovendeerd, P. H. M., Prinzen, F. W., & Reneman, R. S. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82201-9 · Cited by 229 · see citing works
Mechanical Stretch Regimen Enhances the Formation of Bioengineered Autologous Cardiac Muscle Grafts
Akhyari, P., Fedak, P. W. M., Weisel, R. D., Lee, T. J., Verma, S., Mickle, D. A. G., & Li, R. (2002) · Circulation · doi:10.1161/01.cir.0000032893.55215.fc · Cited by 228 · see citing works
Butcher, J. T., & Nerem, R. M. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.905 · Cited by 226 · see citing works
Mol, A., Driessen, N. J. B., Rutten, M. C. M., et al. (2005) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-8025-4 · Cited by 225 · see citing works
Minimally-Invasive Implantation of Living Tissue Engineered Heart Valves
Schmidt, D., Dijkman, P. E., Driessen‐Mol, A., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.04.024 · Cited by 224 · see citing works
Self-citationDrug-sensing hydrogels for the inducible release of biopharmaceuticals
Ehrbar, M., Schoenmakers, R. G., Christen, E. H., Fussenegger, M., & Weber, W. (2008) · Nature Materials · doi:10.1038/nmat2250 · Cited by 222 · see citing works
Co-assembling peptides as defined matrices for endothelial cells
Jung, J. P., Nagaraj, A. K., Fox, E. K., Rudra, J. S., Devgun, J. M., & Collier, J. H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.033 · Cited by 219 · see citing works
McDevitt, T. C., Woodhouse, K. A., Hauschka, S. D., Murry, C. E., & Stayton, P. S. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10504 · Cited by 219 · see citing works
Fabrication of biodegradable elastomeric scaffolds with sub‐micron morphologies
Stankus, J. J., Guan, J., & Wagner, W. R. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30122 · Cited by 217 · see citing works
The collagen matrix of the heart.
Borg, T. K., & Caulfield, J. (1981) · PubMed · Cited by 212 · see citing works
Emerging peptide nanomedicine to regenerate tissues and organs
Webber, M. J., Kessler, J. A., & Stupp, S. I. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02184.x · Cited by 212 · see citing works
Self-Assembly and Biomaterials
Stupp, S. I. (2010) · Nano Letters · doi:10.1021/nl103567y · Cited by 209 · see citing works
Review: Advances in Vascular Tissue Engineering Using Protein-Based Biomaterials
Stegemann, J. P., Kaszuba, S. N., & Rowe, S. L. (2007) · Tissue Engineering · doi:10.1089/ten.2007.0196 · Cited by 207 · see citing works
Benton, J. A., Fairbanks, B. D., & Anseth, K. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.08.031 · Cited by 205 · see citing works
Micromechanics of the fibrosa and the ventricularis in aortic valve leaflets
Veselý, I., & Noseworthy, R. (1992) · Journal of Biomechanics · doi:10.1016/0021-9290(92)90249-z · Cited by 203 · see citing works
Microgravity tissue engineering
Freed, L. E., & Vunjak‐Novakovic, G. (1997) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-997-0009-2 · Cited by 202 · see citing works
Balguid, A., Rubbens, M. P., Mol, A., et al. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0279 · Cited by 202 · see citing works
Sodian, R., Sperling, J. S., Martin, D. P., Egozy, A., Stock, U. A., Mayer, J. E., & Vacanti, J. P. (2000) · Tissue Engineering · doi:10.1089/107632700320793 · Cited by 201 · see citing works
New Pulsatile Bioreactor for In Vitro Formation of Tissue Engineered Heart Valves
Hoerstrup, S. P., Sodian, R., Sperling, J. S., et al. (2000) · Tissue Engineering · doi:10.1089/107632700320919 · Cited by 201 · see citing works
Au, H. T. H., Cheng, I. G., Chowdhury, M. F., & Radisic, M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.001 · Cited by 200 · see citing works
Anversa, P. (1980) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(80)90080-2 · Cited by 187 · see citing works
Functional Growth in Tissue-Engineered Living, Vascular Grafts
Hoerstrup, S. P., Ian Cummings, M. R. C. S., Lachat, M. L., Schöen, F. J., Jenni, R., Leschka, S., Neuenschwander, S., Schmidt, D., Mol, A., Günter, C. I., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.001172 · Cited by 186 · see citing works
Hahn, M. S., McHale, M. K., Wang, E., Schmedlen, R. H., & West, J. L. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-006-9099-3 · Cited by 185 · see citing works
Evaluation of Biodegradable, Three-Dimensional Matrices for Tissue Engineering of Heart Valves
Sodian, R., Hoerstrup, S. P., Sperling, J. S., et al. (2000) · ASAIO Journal · doi:10.1097/00002480-200001000-00025 · Cited by 182 · see citing works
Currier, J. W., & Faxon, D. P. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)98445-j · Cited by 181 · see citing works
Syedain, Z. H., Weinberg, J. S., & Tranquillo, R. T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711217105 · Cited by 181 · see citing works
Jawad, H., Lyon, A. R., Harding, S. E., Ali, N. N., & Boccaccini, A. R. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn026 · Cited by 181 · see citing works
Protein-based signaling systems in tissue engineering
Boontheekul, T., & Mooney, D. J. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.08.004 · Cited by 180 · see citing works
Protein engineering approaches to biomaterials design
Maskarinec, S. A., & Tirrell, D. A. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.06.009 · Cited by 178 · see citing works
Sandusky, G. E., Badylak, S. F., Morff, R. J., Johnson, W. D., & Lantz, G. C. (1992) · PubMed Central · Cited by 177 · see citing works
Nerem, R. M. (1991) · Annals of Biomedical Engineering · doi:10.1007/bf02367396 · Cited by 175 · see citing works
Zhong, Teo, W. E., Zhu, X., Beuerman, R. W., Ramakrishna, S., & Yung, L. Y. L. (2005) · Biomacromolecules · doi:10.1021/bm050318p · Cited by 174 · see citing works
Krahn, K. N., Bouten, C. V. C., van Tuijl, S., van Zandvoort, M. A. M. J., & Merkx, M. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.01.013 · Cited by 172 · see citing works
Self-citationA computational model for collagen fibre remodelling in the arterial wall
Driessen, N. J. B., Wilson, W., Bouten, C. V. C., et al. (2003) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2003.08.004 · Cited by 171 · see citing works
Self-citationStekelenburg, M. M., Rutten, M. C. M., Snoeckx, L. H. E. H., et al. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0183 · Cited by 171 · see citing works
Singelyn, J. M., & Christman, K. L. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9202-x · Cited by 170 · see citing works
Heart muscle engineering: An update on cardiac muscle replacement therapy
Zimmermann, W., Didié, M., Döker, S., Melnychenko, I., NAITO, H., Rogge, C., Tiburcy, M., & Thomas Eschenhagen, A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.03.023 · Cited by 169 · see citing works
A PEGylated Fibrin Patch for Mesenchymal Stem Cell Delivery
Zhang, G., Wang, X., Wang, Z., et al. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.9 · Cited by 169 · see citing works
Smits, A. M., Laake, L. W. V., den Ouden, K., Schreurs, C., Szuhai, K., van Echteld, C. J. A., Mummery, C. L., Doevendans, P. A., & Goumans, M. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp146 · Cited by 167 · see citing works
L’Heureux, N., Stoclet, J., Auger, F. A., Lagaud, G., Germain, L., & Andriantsitohaina, R. (2001) · The FASEB Journal · doi:10.1096/fj.00-0283com · Cited by 165 · see citing works
Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells
Hoerstrup, S. P., Kadner, A., Breymann, C., Maurus, C. F., Guenter, C. I., Sodian, R., Visjager, J., Zünd, G., & Turina, M. I. (2002) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)03649-4 · Cited by 164 · see citing works
Flanagan, T. C., Sachweh, J. S., Frese, J., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0018 · Cited by 162 · see citing works
Dynamic Interactions between Myocytes, Fibroblasts, and Extracellular Matrix
Banerjee, I., Yekkala, K., Borg, T. K., et al. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1380.007 · Cited by 158 · see citing works
Wall shear stress in normal left coronary artery tree
Soulis, J. V., Farmakis, T. M., Giannoglou, G. D., et al. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.12.026 · Cited by 158 · see citing works
Fabrication of Pliable Biodegradable Polymer foams to Engineer Soft Tissues
Wake, M. C., Gupta, P. K., & Mikos, A. G. (1996) · Cell Transplantation · doi:10.1016/0963-6897(96)00025-5 · Cited by 158 · see citing works
Hong, Y., Ye, S., Nieponice, A., Soletti, L., Vorp, D. A., & Wagner, W. R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.013 · Cited by 157 · see citing works
Brennan, M. P., Dardik, A., Hibino, N., Roh, J. D., Nelson, G. N., Papademitris, X., Shinoka, T., & Breuer, C. K. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e318184dcbd · Cited by 157 · see citing works
Mechanobiology of the aortic heart valve.
Butcher, J. T., Simmons, C. A., & Warnock, J. N. (2008) · PubMed · Cited by 154 · see citing works
van Andel, C. J., Pistecky, P. V., & Borst, C. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(03)00263-7 · Cited by 153 · see citing works
Percutaneous Cell Delivery into the Heart Using Hydrogels Polymerizing in Situ
Martens, T. P., Godier, A. F. G., Parks, J. J., et al. (2009) · Cell Transplantation · doi:10.3727/096368909788534915 · Cited by 151 · see citing works
Nieponice, A., Soletti, L., Guan, J., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0427 · Cited by 150 · see citing works
Flanagan, T. C., Cornelissen, C. G., Koch, S., et al. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.04.012 · Cited by 148 · see citing works
Tissue engineering of heart valves: advances and current challenges
Mol, A., Smits, A. I. P. M., Bouten, C. V. C., & Baaijens, F. F. (2009) · Expert Review of Medical Devices · doi:10.1586/erd.09.12 · Cited by 147 · see citing works
Self-citationJin, J., Jeong, S. I., Shin, Y. M., Lim, K. S., Shin, H. S., Lee, Y. M., Koh, H. C., & Kim, K. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn017 · Cited by 146 · see citing works
Role of Imaging in Cardiac Stem Cell Therapy
Beeres, S. L. M. A., Bengel, F. M., Bartúnek, J., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.072 · Cited by 146 · see citing works
Yokota, T., Ichikawa, H., Matsumiya, G., et al. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.02.058 · Cited by 146 · see citing works
Body surface area as a predictor of aortic and pulmonary valve diameter
Capps, S. B., Elkins, R. C., & Fronk, D. M. (2000) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(00)70092-4 · Cited by 146 · see citing works
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In vitro cardiac tissue models: Current status and future prospects
Mathur, A., Ma, Z., Loskill, P., Jeeawoody, S., & Healy, K. E. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.011 · Cited by 187 · see citing works
Fibrous scaffolds for building hearts and heart parts
Capulli, A. K., MacQueen, L. A., Sheehy, S. P., & Parker, K. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.020 · Cited by 130 · see citing works
JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement
Capulli, A. K., Emmert, M. Y., Pasqualini, F. S., Kehl, D., Caliskan, E., Lind, J. U., Sheehy, S. P., Park, S. J., Ahn, S., Weber, B., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.033 · Cited by 112 · see citing works
Hinderer, S., Brauchle, E., & Schenke‐Layland, K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201400762 · Cited by 68 · see citing works
Liu, Y., Kamran, R., Han, X., Wang, M., Li, Q., Lai, D., Naruse, K., & Takahashi, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-68275-0 · Cited by 47 · see citing works
Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
- Authors
- Bouten, C. V. C., Dankers, P. Y. W., Driessen-Mol, A., Pedron, S., Brizard, A. M. A., & Baaijens, F. P. T.
- Affiliations
- Eindhoven University of Technology (NL)
- Philips (Netherlands) (NL)
- Corresponding author
- Bouten, C.V.C.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 63
- Issue
- 4-5
- Pages
- 221-241
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2065678169
- Cited by
- 261
- References
- 335
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 11 · 2020: 18 · 2019: 22 · 2018: 28 · 2017: 21 · 2016: 21 · 2015: 20 · 2014: 26 · 2013: 19 · 2012: 14
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- TU/e Research Portal (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- cardiovascular tissue engineering, biomaterial substrates, tissue engineering scaffolds, in situ tissue engineering
- MeSH terms
- Animals, Biocompatible Materials, Cardiovascular Diseases, Coronary Vessels, Heart Valves, Humans, Myocardium, Regeneration, Cardiovascular Surgical Procedures, Tissue Engineering, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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