Cited by 261Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applications

Substrates for cardiovascular tissue engineering

Bouten, C.V.C., Dankers, P.Y.W., Driessen-Mol, A., Pedron, S., Brizard, A.M.A., Baaijens, F.P.T.·2011·Advanced Drug Delivery Reviews

Abstract

Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of heart valves, arteries and myocardium by creating 'living' tissue replacements outside (in vitro) or inside (in situ) the human body. A combination of cells, biomaterials and environmental cues of tissue development is employed to obtain tissues with targeted structure and functional properties that can survive and develop within the harsh hemodynamic environment of the cardiovascular system. This paper reviews the up-to-date status of cardiovascular tissue engineering with special emphasis on the development and use of biomaterial substrates. Key requirements and properties of these substrates, as well as methods and readout parameters to test their efficacy in the human body, are described in detail and discussed in the light of current trends toward designing biologically inspired microenviroments for in situ tissue engineering purposes.

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Registry

Crossref · 10.1016/j.addr.2011.01.007

Cites

335 of 335 references verified0 citation errors · 0 not checkable

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  • Imparting anti-thrombogenic and anti-calcification properties is crucial for artificial heart valves, capabilities that PLCL inherently lacks.

    “imparting anti-thrombogenic and anti-calcification properties is crucial for artificial heart valves, capabilities that PLCL inherently lacks, and PLCL itself does not have these capabilities [170].”
  • Valve surface needs to withstand continuous impact of blood flow, making it prone to deposits such as calcification and thrombosis.

    “the valve surface needs to withstand the continuous impact of blood flow, making it prone to deposits such as calcification and thrombosis.”

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Authors
Bouten, C. V. C., Dankers, P. Y. W., Driessen-Mol, A., Pedron, S., Brizard, A. M. A., & Baaijens, F. P. T.
Affiliations
  • Eindhoven University of Technology (NL)
  • Philips (Netherlands) (NL)
Corresponding author
Bouten, C.V.C.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2011-04
Volume
63
Issue
4-5
Pages
221-241
ISSN
0169-409X (ISSN-L)
OpenAlex
W2065678169
Cited by
261
References
335
Citations by year
2026: 4 · 2025: 12 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 11 · 2020: 18 · 2019: 22 · 2018: 28 · 2017: 21 · 2016: 21 · 2015: 20 · 2014: 26 · 2013: 19 · 2012: 14
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • TU/e Research Portal (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
cardiovascular tissue engineering, biomaterial substrates, tissue engineering scaffolds, in situ tissue engineering
MeSH terms
Animals, Biocompatible Materials, Cardiovascular Diseases, Coronary Vessels, Heart Valves, Humans, Myocardium, Regeneration, Cardiovascular Surgical Procedures, Tissue Engineering, Tissue Scaffolds

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