The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Novel Biocompatible Polysaccharide‐Based Self‐Healing Hydrogel
Abstract
A novel biocompatible polysaccharide‐based self‐healing hydrogel, CEC‐l‐OSA‐l‐ADH hydrogel (“l” means “linked‐by”), is developed by exploiting the dynamic reaction of N‐carboxyethyl chitosan (CEC) and adipic acid dihydrazide (ADH) with oxidized sodium alginate (OSA). The self‐healing ability, as demonstrated by rheological recovery, macroscopic observation, and beam‐shaped strain compression measurement, is attributed to the coexistence of dynamic imine and acylhydrazone bonds in the hydrogel networks. The CEC‐l‐OSA‐l‐ADH hydrogel shows excellent self‐healing ability under physiological conditions with a high healing efficiency (up to 95%) without need for any external stimuli. In addition, the CEC‐l‐OSA‐l‐ADH hydrogel exhibits good cytocompatibility and cell release as demonstrated by three‐dimensional cell encapsulation. With these superior properties, the developed hydrogel holds great potential for applications in various biomedical fields, e.g., as cell or drug delivery carriers.
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Citations
Cites
Hydrogels for biomedical applications
Hoffman, A. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.010 · Cited by 3,396
Self-healing gels based on constitutional dynamic chemistry and their potential applications
Wei, Z., Yang, J. H., Zhou, J., Xu, F., Zrínyi, M., Dussault, P. H., Osada, Y., & Chen, Y. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00219a · Cited by 896
Self-citation
Cited by
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Self-citationZhao, X., Liang, Y., Huang, Y., He, J., Han, Y., & Guo, B. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910748 · Cited by 814
A mini review on hydrogels classification and recent developments in miscellaneous applications
Varaprasad, K., Raghavendra, G. M., Jayaramudu, T., Yallapu, M. M., & Sadiku, R. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.05.096 · Cited by 534
Gao, F., Xu, Z., Liang, Q., Li, H., Peng, L., Wu, M., Zhao, X., Cui, X., Ruan, C., & Liu, W. (2019) · Advanced Science · doi:10.1002/advs.201900867 · Cited by 365
Development of alginate-based hydrogels: Crosslinking strategies and biomedical applications
Tan, J., Luo, Y., Guo, Y., Zhou, Y., Liao, X., Li, D., Lai, X., & Liu, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124275 · Cited by 308
Metadata
- Authors
- Wei, Z., Yang, J. H., Liu, Z. Q., Xu, F., Zhou, J. X., Zrínyi, M., Osada, Y., & Chen, Y. M.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2015-01-14
- Volume
- 25
- Issue
- 9
- Pages
- 1352-1359
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2123971331
- Cited by
- 660
- References
- 2
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wei, Z., Yang, J. H., Liu, Z. Q., Xu, F., Zhou, J. X., Zrínyi, M., Osada, Y., & Chen, Y. M. (2015). Novel Biocompatible Polysaccharide‐Based Self‐Healing Hydrogel. Advanced Functional Materials. https://doi.org/10.1002/adfm.201401502
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