Hydrogels for biomedical applications

Hydrogels for Tissue Engineering

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Hydrophilic gels for biological use

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Microencapsulated Islets as Bioartificial Endocrine Pancreas

Lim, F., & Sun, A. M. (1980) · Science · doi:10.1126/science.6776628 · Cited by 2,377 · see citing works

Scaffold design and fabrication technologies for engineering tissues — state of the art and future perspectives

Hutmacher, D. W. (2001) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856201744489 · Cited by 1,412 · see citing works

Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin

Yannas, I. V., Lee, E., Orgill, D. P., Skrabut, E. M., & Murphy, G. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.933 · Cited by 972 · see citing works

Polymeric biomaterials

Griffith, L. G. (2000) · Acta Materialia · doi:10.1016/s1359-6454(99)00299-2 · Cited by 733 · see citing works

Hydrogels for Medical and Related Applications

Andrade, J. D. (1976) · ACS symposium series · doi:10.1021/bk-1976-0031 · Cited by 582 · see citing works

Transdermal photopolymerization for minimally invasive implantation

Elisseeff, J. H., Anseth, K. S., Sims, D. C., McIntosh, W., Randolph, M. A., & Langer, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3104 · Cited by 576 · see citing works

Semisynthetic resorbable materials from hyaluronan esterification

Campoccia, D. (1998) · Biomaterials · doi:10.1016/s0142-9612(98)00042-8 · Cited by 529 · see citing works

Cyclic mechanical strain regulates the development of engineered smooth muscle tissue

Kim, B., Nikolovski, J., Bonadio, J. F., et al. (1999) · Nature Biotechnology · doi:10.1038/13671 · Cited by 492 · see citing works

Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives

Prestwich, G. D., Marecak, D. M., Marecek, J. F., Vercruysse, K. P., & Ziebell, M. R. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00242-3 · Cited by 423 · see citing works

Synthesis and Characterization of Injectable Poly(N-isopropylacrylamide)-Based Hydrogels That Support Tissue Formation in Vitro

Stile, R. A., Burghardt, W. R., & Healy, K. E. (1999) · Macromolecules · doi:10.1021/ma990130w · Cited by 363 · see citing works

Comparative study of the use of poly(glycolic acid), calcium alginate and pluronics in the engineering of autologous porcine cartilage

Cao, Y., Rodriguez, A. M., Vacanti, M., Ibarra, C., Arevalo, C., & Vacanti, C. A. (1998) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856298x00578 · Cited by 293 · see citing works

In Vitro and in Vivo Performance of Porcine Islets Encapsulated in Interfacially Photopolymerized Poly(Ethylene Glycol) Diacrylate Membranes

Cruise, G. M., Hegre, O. D., Lamberti, F. V., Hager, S. R., Hill, R. L., Scharp, D. S., & Hubbell, J. A. (1999) · Cell Transplantation · doi:10.1177/096368979900800310 · Cited by 273 · see citing works

Crosslinking characteristics of an injectable poly(propylene fumarate)/?-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement

Peter, S. J., Kim, P., Yasko, A. W., Yaszemski, M. J., & Mikos, A. G. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990305)44:3 · Cited by 205 · see citing works

The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold

Dillon, G. P., Yu, X., Sridharan, A., Ranieri, J. P., & Bellamkonda, R. V. (1998) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856298x00325 · Cited by 191 · see citing works

COVALENT BINDING OF BIOMOLECULES TO RADIATION-GRAFTED HYDROGELS ON INERT POLYMER SURFACES

Hoffman, A., Schmer, G., Harris, C., et al. (1972) · ASAIO Journal · doi:10.1097/00002480-197201000-00003 · Cited by 167 · see citing works

Three-dimensional extracellular matrix engineering in the nervous system

Borkenhagen, M., Cl�mence, J.-F., Sigrist, H., & Aebischer, P. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19980603)40:3 · Cited by 157 · see citing works

Making microencapsulation work: conformal coating, immobilization gels and in vivo performance

Sefton, M. V., May, M. H., Lahooti, S., & Babensee, J. E. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00234-5 · Cited by 140 · see citing works

Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell‐adhesion‐resistant surfaces

Drumheller, P. D., & Hubbell, J. A. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820290211 · Cited by 133 · see citing works

Synthetic biodegradable polymers for tissue engineering and drug delivery

Hubbell, J. A. (1998) · Current Opinion in Solid State and Materials Science · doi:10.1016/s1359-0286(98)80098-3 · Cited by 121 · see citing works

Soft-Tissue Augmentation with Injectable Alginate and Syngeneic Fibroblasts

Marler, J. J., Guha, A., Rowley, J., et al. (2000) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200005000-00020 · Cited by 117 · see citing works

Controlled Drug Delivery

Robinson, J., & Lee, V. H. L. (1987) · CRC Press eBooks · doi:10.1201/9781003041054 · Cited by 103 · see citing works

Development of Poly(Propylene Fumarate-co-Ethylene Glycol) as an Injectable Carrier for Endothelial Cells

Suggs, L. J., & Mikos, A. G. (1999) · Cell Transplantation · doi:10.1177/096368979900800402 · Cited by 94 · see citing works

Formation of poly(glucosyloxyethyl methacrylate)-Concanavalin A complex and its glucose-sensitivity

Nakamae, K., Miyata, T., Jikihara, A., et al. (1995) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856295x00779 · Cited by 87 · see citing works

Novel Fabrication of Open-Pore Chitin Matrixes

Chow, K. S., & Khor, E. (2000) · Biomacromolecules · doi:10.1021/bm005503b · Cited by 87 · see citing works

Synthesis of novel hydrolytically degradable hydrogels for controlled drug release

Ulbrich, K. (1995) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00004-r · Cited by 82 · see citing works

Complex Coacervate Microcapsules for Mammalian Cell Culture and Artificial Organ Development

Matthew, H. W. T., Salley, S. O., Peterson, W. D., et al. (1993) · Biotechnology Progress · doi:10.1021/bp00023a010 · Cited by 81 · see citing works

Dextran permeation through poly(N-isopropylacrylamide) Hydrogels

Dong, L. C., Hoffman, A. S., & Qi, Y. (1994) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856294x00158 · Cited by 46 · see citing works

Affinity precipitation of proteins by polyligands

Morris, J. E., Hoffman, A. S., & Fisher, R. R. (1993) · Biotechnology and Bioengineering · doi:10.1002/bit.260411010 · Cited by 44 · see citing works

Porous Hydrogels for Neural Tissue Engineering

Woerly, S. (1997) · Materials science forum · doi:10.4028/www.scientific.net/msf.250.53 · Cited by 39 · see citing works

Growth Factor Release from Gelatin Hydrogel for Tissue Engineering

Yamamoto, M., Tabata, Y., & Ikada, Y. (1999) · Journal of Bioactive and Compatible Polymers · doi:10.1177/088391159901400603 · Cited by 39 · see citing works

Lack of responsiveness to glucose of microencapsulated islets of Langerhans after three weeks' implantation in the rat—influence of the complement

Gin, H., Dupuy, B., Baquey, A., et al. (1990) · Journal of Microencapsulation · doi:10.3109/02652049009021844 · Cited by 31 · see citing works

The Collagen-Containing Alginate/Poly(L-Lysine)/Alginate Microcapsules

Hsu, F., Tsai, S. W., Wang, F. F., et al. (2000) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.3109/10731190009118577 · Cited by 25 · see citing works

Untitled work

Jenney (2000) · doi:10.1002/(sici)1097-4636(20000315)49:4

pH-Responsive polymers

Kocak, G., Tuncer, C., & Bütün, V. (2017) · Polymer Chemistry · doi:10.1039/c6py01872f · Cited by 1,189 · see citing works

Direct 3D bioprinting of perfusable vascular constructs using a blend bioink

Jia, W., Gungor-Ozkerim, P. S., Zhang, Y. S., Yue, K., Zhu, K., Liu, W., Pi, Q., Byambaa, B., Dokmeci, M. R., Shin, S. R., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.038 · Cited by 922 · see citing works

Designing degradable hydrogels for orthogonal control of cell microenvironments

Kharkar, P. M., Kiick, K. L., & Kloxin, A. M. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60040h · Cited by 717 · see citing works

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works

Review on recent progress in chitosan-based hydrogels for wastewater treatment application

Mohammadzadeh Pakdel, P., & Peighambardoust, S. J. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.070 · Cited by 578 · see citing works

Cellulose-based hydrogel materials: chemistry, properties and their prospective applications

Kabir, S. M. F., Sikdar, P. P., Haque, B., Bhuiyan, M. A. R., Ali, A., & Islam, M. N. (2018) · Progress in Biomaterials · doi:10.1007/s40204-018-0095-0 · Cited by 565 · see citing works

A mini review on hydrogels classification and recent developments in miscellaneous applications

Varaprasad, K., Raghavendra, G. M., Jayaramudu, T., Yallapu, M. M., & Sadiku, R. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.05.096 · Cited by 534 · see citing works

Recent progress in synthesis and application of mussel-inspired adhesives

Guo, Q., Chen, J., Wang, J., Zeng, H., & Yu, J. (2020) · Nanoscale · doi:10.1039/c9nr09780e · Cited by 370 · see citing works

<scp>pH</scp> ‐sensitive polymers: Classification and some fine potential applications

Ofridam, F., Tarhini, M., Lebaz, N., Gagnière, É., Mangin, D., & Elaissari, A. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5230 · Cited by 286 · see citing works

Functionalized Hydrogel-Based Wearable Gas and Humidity Sensors.

Luo, Y., Li, J., Ding, Q., Wang, H., Liu, C., & Wu, J. (2023) · Nano-Micro Letters · doi:10.1007/s40820-023-01109-2 · Cited by 236 · see citing works

Advancing bioinks for 3D bioprinting using reactive fillers: a review

Heid, S., & Boccaccini, A. R. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.06.040 · Cited by 224 · see citing works

ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging

Lee, E., Choi, J., Jo, Y., Kim, J. Y., Jang, Y. J., Lee, H. M., Kim, S. Y., Lee, H.-J., Cho, K., Jung, N., et al. (2016) · Scientific Reports · doi:10.1038/srep18631 · Cited by 215 · see citing works

Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems

Delgado-Pujol, E. J., Martínez, G., Casado-Jurado, D., Vázquez, J., León-Barberena, J., Rodríguez-Lucena, D., Torres, Y., Alcudia, A., & Begines, B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020215 · Cited by 216 · see citing works

Poly(lactic acid) based hydrogels

Basu, A., Kunduru, K. R., Doppalapudi, S., Domb, A. J., & Khan, W. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.004 · Cited by 188 · see citing works

Emerging materials for hemostasis

Li, X.-F., Lu, P., Jia, H.-R., Li, G., Zhu, B., Wang, X., & Wu, F.-G. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214823 · Cited by 164 · see citing works

Hydrogels to model 3D in vitro microenvironment of tumor vascularization

Song, H.-H. G., Park, K. M., & Gerecht, S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.06.002 · Cited by 153 · see citing works

Hydrogels as artificial matrices for cell seeding in microfluidic devices

Akther, F., Little, P., Li, Z., Nguyen, N.-T., & Ta, H. T. (2020) · RSC Advances · doi:10.1039/d0ra08566a · Cited by 127 · see citing works

Mechanoresponsive materials for drug delivery: Harnessing forces for controlled release

Wang, J., Kaplan, J. A., Colson, Y. L., & Grinstaff, M. W. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.11.001 · Cited by 126 · see citing works

A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

Wang, X., Maxwell, K. G., Wang, K., Bowers, D. T., Flanders, J. A., Liu, W., Wang, L.-H., Liu, Q., Liu, C., Naji, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb4601 · Cited by 119 · see citing works

Nanofibrillar cellulose hydrogels and reconstructed hydrogels as matrices for controlled drug release

Paukkonen, H., Kunnari, M., Laurén, P., Hakkarainen, T., Auvinen, V.-V., Oksanen, T., Koivuniemi, R., Yliperttula, M., & Laaksonen, T. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.002 · Cited by 109 · see citing works

Supramolecular design and applications of polyphenol-based architecture: A review

Liang, H., Zhou, B., Wu, D., Li, J., & Li, B. (2019) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2019.102019 · Cited by 98 · see citing works

Crosslinking strategies for silk fibroin hydrogels: promising biomedical materials

Farokhi, M., Aleemardani, M., Solouk, A., Mirzadeh, H., Teuschl, A. H., & Redl, H. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abb615 · Cited by 95 · see citing works

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

Casadidio, C., Vargas Peregrina, D., Gigliobianco, M. R., Deng, S., Censi, R., & Di Martino, P. (2019) · doi:10.20944/preprints201905.0066.v1 · Cited by 350 · see citing works

Drug Delivery Systems as a Strategy to Improve the Efficacy of FDA-Approved Alzheimer’s Drugs

Nunes, D., Loureiro, J. A., & Pereira, M. C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112296 · Cited by 68 · see citing works

Thermogelling chitosan-based polymers for the treatment of oral mucosa ulcers

Luo, Z., Xue, K., Zhang, X., Lim, J. Y. C., Lai, X., Young, D. J., Zhang, Z.-X., Wu, Y.-L., & Loh, X. J. (2020) · Biomaterials Science · doi:10.1039/c9bm01754b · Cited by 67 · see citing works

Zwitteration of dextran: A facile route to integrate antifouling, switchability and optical transparency into natural polymers

Cao, B., Li, L., Wu, H., Tang, Q., Sun, B., Dong, H., Zhe, J., & Cheng, G. (2014) · Chem. Commun. · doi:10.1039/c3cc48878k · Cited by 66 · see citing works

Basement membrane properties and their recapitulation in organ-on-chip applications

Salimbeigi, G., Vrana, N. E., Ghaemmaghami, A. M., Huri, P. Y., & McGuinness, G. B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100301 · Cited by 57 · see citing works

β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation

Malik, N. S., Ahmad, M., Alqahtani, M. S., Mahmood, A., Barkat, K., Khan, M. T., Tulain, U. R., & Rashid, A. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1921074 · Cited by 57 · see citing works

Characterization of silk hydrogel formed with hydrolyzed silk fibroin-methacrylate via photopolymerization

Kim, H. H., Kim, J. W., Choi, J., Park, Y. H., & Ki, C. S. (2018) · Polymer · doi:10.1016/j.polymer.2018.08.019 · Cited by 53 · see citing works

Cancer immunotherapy μ-environment LabChip: taking advantage of optoelectronic tweezers

Ke, L.-Y., Kuo, Z.-K., Chen, Y.-S., Yeh, T.-Y., Dong, M., Tseng, H.-W., & Liu, C.-H. (2018) · Lab on a Chip · doi:10.1039/c7lc00963a · Cited by 50 · see citing works

A pH-Responsive Amphiphilic Hydrogel Based on Pseudopeptides and Poly(ethylene glycol) for Oral Delivery of Hydrophobic Drugs

Wang, S., Attah, R., Li, J., Chen, Y., & Chen, R. (2018) · ACS Biomaterials Science &amp; Engineering · doi:10.1021/acsbiomaterials.8b01040 · Cited by 29 · see citing works

Third Generation Cyclodextrin Graft with Polyurethane Embedded in Hydrogel for a Sustained Drug Release: Complete Shrinkage of Melanoma

Shukla, A., Singh, A. P., Dubey, T., Hemalatha, S., & Maiti, P. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00171 · Cited by 27 · see citing works

The effect of methacrylation on the behavior of Gum Arabic as pH-responsive matrix for colon-specific drug delivery

Gerola, A. P., Silva, D. C., Matsushita, A. F. Y., Borges, O., Rubira, A. F., Muniz, E. C., & Valente, A. J. M. (2016) · European Polymer Journal · doi:10.1016/j.eurpolymj.2016.03.041 · Cited by 26 · see citing works

Functionalized Textile Based Therapy for the Treatment of Atopic Dermatitis

Wang, W., Hui, P., & Kan, C.-W. (2017) · Coatings · doi:10.3390/coatings7060082 · Cited by 22 · see citing works

The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review

Tharakan, S., Raja, I., Pietraru, A., Sarecha, E., Gresita, A., Petcu, E., Ilyas, A., & Hadjiargyrou, M. (2023) · Gels · doi:10.3390/gels9040274 · Cited by 18 · see citing works

Injectable microgel–hydrogel composites “plum pudding gels”: new system for prolonged drug delivery

Bayat, M., & Nasri, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816505-8.00001-1 · Cited by 17 · see citing works

The Application of Hydrogels Based on Natural Polymers for Tissue Engineering

Taghipour, Y. D., Hokmabad, V. R., Bakhshayesh, A. R. D., et al. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190711103956 · Cited by 114 · see citing works

Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications

Larrañeta, E., Stewart, S. A., Ervine, M., Al-Kasasbeh, R., & Donnelly, R. F. (2018) · Journal of Functional Biomaterials · doi:10.3390/jfb9010013 · Cited by 305 · see citing works

Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs

McKenzie, M., Betts, D., Suh, A., Bui, K., Kim, L., & Cho, H. (2015) · Molecules · doi:10.3390/molecules201119705 · Cited by 212 · see citing works

Microengineered hydrogels for tissue engineering

Khademhosseini, A., & Langer, R. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.021 · Cited by 830 · see citing works