The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
DNA/Tannic Acid Hybrid Gel Exhibiting Biodegradability, Extensibility, Tissue Adhesiveness, and Hemostatic Ability
Abstract
DNA has emerged as a novel material in many areas of materials science due to its programmability. Especially, DNA hydrogels have been studied to incorporate new functions into gels. To date, only a few methods have been developed for fabricating DNA hydrogels, such as the use of complementary sequences or covalent bond. Herein, it is demonstrated that one of the most well‐known plant‐derived polyphenols, tannic acid (TA), can form a DNA hydrogel which is named TNA hydrogel (TA + DNA). TA plays a role as a “molecular glue” by a new mode of action reversibly connecting between phosphodiester bonds, which is different from the crosslinking utilizing complementary sequences. TA intrinsically degrades due to ester bonds connecting between pyrogallol groups, causing a degradable DNA hydrogel. Furthermore, TNA gel is multifunctional in that the gel is extensible upon pulling and adhesive to tissues because of the rich polyphenol groups in TA (ten phenols per TA). Unexpectedly, TNA gel exhibits superior in vivo hemostatic ability that can be useful for biomedical applications. This new DNA hydrogel preparation method represents a new technique for fabricating a large amount of DNA‐based hemostatic hydrogel without chemically modifying DNA or requiring the crosslinking by complementary sequences.
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Cited by
A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Hong, Y., Zhou, F., Hua, Y., Zhang, X., Ni, C., Pan, D., Zhang, Y., Jiang, D., Yang, L., Lin, Q., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10004-7 · Cited by 836
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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery
Guo, Y., Sun, Q., Wu, F., Dai, Y., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202007356 · Cited by 650
Supramolecular Hydrogel Formation Based on Tannic Acid
Fan, H., Wang, L., Feng, X., Bu, Y., Wu, D., & Jin, Z. (2017) · Macromolecules · doi:10.1021/acs.macromol.6b02106 · Cited by 474
Polyphenol scaffolds in tissue engineering
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Metadata
- Authors
- Shin, M., Ryu, J. H., Park, J. P., Kim, K., Yang, J. W., & Lee, H.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2015-01-16
- Volume
- 25
- Issue
- 8
- Pages
- 1270-1278
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2011820088
- Cited by
- 345
- References
- 46
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shin, M., Ryu, J. H., Park, J. P., Kim, K., Yang, J. W., & Lee, H. (2015). DNA/Tannic Acid Hybrid Gel Exhibiting Biodegradability, Extensibility, Tissue Adhesiveness, and Hemostatic Ability. Advanced Functional Materials. https://doi.org/10.1002/adfm.201403992
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