The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
Open accessAbstract
Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant.
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Cites
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Cited by
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
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Metadata
- Authors
- Hong, Y., Zhou, F., Hua, Y., Zhang, X., Ni, C., Pan, D., Zhang, Y., Jiang, D., Yang, L., Lin, Q., Zou, Y., Yu, D., Arnot, D. E., Zou, X., Zhu, L., Zhang, S., & Ouyang, H.
- Venue
- Nature Communications
- Published
- 2019-05-14
- Volume
- 10
- Issue
- 1
- Pages
- 2060-2060
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2946114052
- Cited by
- 836
- References
- 29
- FWCI
- 26.42
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hong, Y., Zhou, F., Hua, Y., Zhang, X., Ni, C., Pan, D., Zhang, Y., Jiang, D., Yang, L., Lin, Q., Zou, Y., Yu, D., Arnot, D. E., Zou, X., Zhu, L., Zhang, S., & Ouyang, H. (2019). A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds. Nature Communications. https://doi.org/10.1038/s41467-019-10004-7
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