The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Red Light Activatable Multifunctional Prodrug for Image‐Guided Photodynamic Therapy and Cascaded Chemotherapy
Open accessAbstract
A multifunctional prodrug, designated as TPP‐L‐GEM, is fabricated to realize image‐guided in situ tumor photodynamic therapy (PDT) with red light activatable chemotherapy. Gemcitabine is conjugated with a fluorescent photosensitizer, meso‐tetraphenylporphyrin (TPP), by a reactive oxygen species cleavable thioketal linker. Under the irradiation of low‐energy red light, TPP can generate singlet oxygen and damage tumor cells by photodynamic therapy. Simultaneously, the thioketal linkage can be cleaved by singlet oxygen and result in a cascaded gemcitabine release, causing sustained cell damage by chemotherapy. With the combination of PDT and cascaded chemotherapy, TPP‐L‐GEM shows significant tumor therapeutic efficacy in vitro and in vivo. Furthermore, the inherent fluorescent property of TPP endows the TPP‐L‐GEM prodrug with noninvasive drug tracking capability, which is favorable for image‐guided tumor therapy.
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Cites
Gemcitabine versus Modified Gemcitabine: A Review of Several Promising Chemical Modifications
Moysan, E., Bastiat, G., & Benoit, J.-P. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300370t · Cited by 225
The role of hypoxia-activated prodrugs in cancer therapy
Denny, W. A. (2000) · The Lancet Oncology · doi:10.1016/s1470-2045(00)00006-1 · Cited by 167
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Gao, M., Yu, F., Lv, C., Choo, J., & Chen, L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00908e · Cited by 827
Theranostic Fluorescent Probes
Sharma, A., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J.-H., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 499
Wu, W., Mao, D., Hu, F., Xu, S., Chen, C., Zhang, C., Cheng, X., Yuan, Y., Ding, D., Kong, D., et al. (2017) · Advanced Materials · doi:10.1002/adma.201700548 · Cited by 462
Self-citationRahim, M. A., Jan, N., Khan, S., Shah, H., Madni, A., Khan, A., Jabar, A., Khan, S., Elhissi, A., Hussain, Z., et al. (2021) · Cancers · doi:10.3390/cancers13040670 · Cited by 323
Metadata
- Authors
- Liu, L., Qiu, W., Li, B., Zhang, C., Sun, L., Wan, S., Rong, L., & Zhang, X.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2016-07
- Volume
- 26
- Issue
- 34
- Pages
- 6257-6269
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2474783963
- Cited by
- 177
- References
- 2
- FWCI
- 16.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, L., Qiu, W., Li, B., Zhang, C., Sun, L., Wan, S., Rong, L., & Zhang, X. (2016). A Red Light Activatable Multifunctional Prodrug for Image‐Guided Photodynamic Therapy and Cascaded Chemotherapy. Advanced Functional Materials. https://doi.org/10.1002/adfm.201602541
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