The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Low‐Dose X‐ray Activation of W(VI)‐Doped Persistent Luminescence Nanoparticles for Deep‐Tissue Photodynamic Therapy
Abstract
Although photodynamic therapy (PDT) has served as an important strategy for treatment of various diseases, it still experiences many challenges, such as shallow penetration of light, high‐dose light irradiation, and low therapy efficiency in deep tissue. Here, a low‐dose X‐ray‐activated persistent luminescence nanoparticle (PLNP)‐mediated PDT nanoplatform for depth‐independent and repeatable cancer treatment has been reported. In order to improve therapeutic efficiency, this study first synthesizes W(VI)‐doped ZnGa 2 O 4:Cr PLNPs with stronger persistent luminescence intensity and longer persistent luminescence time than traditional ZnGa 2 O 4:Cr PLNPs. The proposed PLNPs can serve as a persistent excitation light source for PDT, even after X‐ray irradiation has been removed. Both in vitro and in vivo experiments demonstrate that low‐dose (0.18 Gy) X‐ray irradiation is sufficient to activate the PDT nanoplatform and causes significant inhibitory effect on tumor progression. Therefore, such PDT nanoplatform will provide a promising depth‐independent treatment mode for clinical cancer therapy in the future.
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Cites
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
Rothkamm, K., & Löbrich, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830918100 · Cited by 1,645
Cited by
High-resolution X-ray luminescence extension imaging
Ou, X., Qin, X., Huang, B., Zan, J., Wu, Q., Hong, Z., Xie, L., Bian, H., Yi, Z., Chen, X., et al. (2021) · Nature · doi:10.1038/s41586-021-03251-6 · Cited by 853
Self-citationX-ray-activated nanosystems for theranostic applications
Chen, X., Song, J., Chen, X., & Yang, H. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00921j · Cited by 401
Self-citationImaging and therapeutic applications of persistent luminescence nanomaterials
Liu, J., Lécuyer, T., Seguin, J., Mignet, N., Scherman, D., Viana, B., & Richard, C. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.015 · Cited by 313
Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics
Hu, H., Feng, W., Qian, X., Yu, L., Chen, Y., & Li, Y. (2021) · Advanced Materials · doi:10.1002/adma.202005062 · Cited by 267
Huang, K., Le, N., Wang, J. S., Huang, L., Zeng, L., Xu, W., Li, Z., Li, Y., & Han, G. (2022) · Advanced Materials · doi:10.1002/adma.202107962 · Cited by 258
Metadata
- Authors
- Song, L., Li, P., Yang, W., Lin, X., Liang, H., Chen, X., Liu, G., Li, J., & Yang, H.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2018-03-08
- Volume
- 28
- Issue
- 18
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2792345771
- Cited by
- 233
- References
- 2
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Song, L., Li, P., Yang, W., Lin, X., Liang, H., Chen, X., Liu, G., Li, J., & Yang, H. (2018). Low‐Dose X‐ray Activation of W(VI)‐Doped Persistent Luminescence Nanoparticles for Deep‐Tissue Photodynamic Therapy. Advanced Functional Materials. https://doi.org/10.1002/adfm.201707496
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