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Cited by 313

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

Imaging and therapeutic applications of persistent luminescence nanomaterials

Open access
Liu, Jianhua, Lécuyer, Thomas, Seguin, Johanne, Mignet, Nathalie, Scherman, Daniel, Viana, Bruno, Richard, Cyrille·2019·Advanced Drug Delivery Reviews

Abstract

&NA; The development of probes for biomolecular imaging and diagnostics is a very active research area. Among the different imaging modalities, optics emerged since it is a noninvasive and cheap imaging technique allowing real time imaging. In vitro, this technique is very useful however in vivo, fluorescence suffers from low signal‐to‐noise ratio due to tissue autofluorescence under constant excitation. To address this limitation, novel types of optical nanoprobes are actually being developed and among them, persistent luminescence nanoparticles (PLNPs), with long lasting near‐infrared (NIR) luminescence capability, allows doing optical imaging without constant excitation and so without autofluorescence. This review will begin by introducing the physical phenomenon associated to the long luminescence decay of such nanoprobes, from minutes to hours after ceasing the excitation. Then we will show how this property can be used to develop in vivo imaging probes and also more recently nanotheranostic agents. Finally, preliminary data on their biocompatibility will be mentioned and we will conclude by envisioning on the future applications and improvements of such nanomaterials.

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Metadata

Authors
Liu, J., Lécuyer, T., Seguin, J., Mignet, N., Scherman, D., Viana, B., & Richard, C.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2019-01
Volume
138
Pages
193-210
ISSN
0169-409X (ISSN-L)
OpenAlex
W2899851841
Cited by
313
References
134
FWCI
1.22
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Imaging and therapeutic applications of persistent luminescence nanomaterials. https://app.cochat.ai/papers/10.1016/j.addr.2018.10.015
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Liu, J., Lécuyer, T., Seguin, J., Mignet, N., Scherman, D., Viana, B., & Richard, C. (2019). Imaging and therapeutic applications of persistent luminescence nanomaterials. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2018.10.015

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