The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Molecular Engineering to Boost AIE‐Active Free Radical Photogenerators and Enable High‐Performance Photodynamic Therapy under Hypoxia
Open accessAbstract
The severe hypoxia in solid tumors and the vicious aggregation‐caused fluorescence quenching (ACQ) of conventional photosensitizers (PSs) have limited the application of fluorescence imaging‐guided photodynamic therapy (PDT), although this therapy has obvious advantages in terms of its precise spatial–temporal control and noninvasive character. PSs featuring type I reactive oxygen species (ROS) based on free radicals and novel aggregation‐induced emission (AIE) characteristics (AIE‐PSs) could offer valuable opportunities to resolve the above problems, but molecular engineering methods are rare in previous reports. Herein, a strategy is proposed for generating stronger intramolecular charge transfer in electron‐rich anion‐π + AIE‐active luminogens (AIEgens) to help suppress nonradiative internal conversion and to promote radiative and intersystem crossing to boost free radical generation. Systematic and detailed experimental and theoretical calculations prove the proposal herein: the electron‐donating abilities are enhanced in collaborative donors, and the AIE‐PSs exhibit higher performance in near‐infrared fluorescence imaging‐guided cancer PDT in vitro / vivo. This work serves as an important reference for the design of AIE‐active free radical generators to overcome the ACQ and tumor hypoxia challenges in PDT.
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Targeting hypoxia in cancer therapy
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Organic solar cells based on non-fullerene acceptors
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Self-citationExploiting tumour hypoxia in cancer treatment
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Self-citationIn vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Self-citationThe fast-growing field of photo-driven theranostics based on aggregation-induced emission
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Metadata
- Authors
- Wan, Q., Zhang, R., Zhuang, Z., Li, Y., Huang, Y., Wang, Z., Zhang, W., Hou, J., & Tang, B. Z.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2020-08-12
- Volume
- 30
- Issue
- 39
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W3048747078
- Cited by
- 363
- References
- 66
- FWCI
- 17.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Wan, Q., Zhang, R., Zhuang, Z., Li, Y., Huang, Y., Wang, Z., Zhang, W., Hou, J., & Tang, B. Z. (2020). Molecular Engineering to Boost AIE‐Active Free Radical Photogenerators and Enable High‐Performance Photodynamic Therapy under Hypoxia. Advanced Functional Materials. https://doi.org/10.1002/adfm.202002057
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