The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Achieving Efficient NIR‐II Type‐I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements
Abstract
Second near‐infrared (NIR‐II) window type‐I photosensitizers have intrinsic advantages in photodynamic/photothermal therapy (PDT/PTT) of some malignant tumors with deep infiltration, large size, complicated location, and low possibility of surgery/radiotherapy. Herein, three chalcogen‐element‐based donor–acceptor‐type semiconducting polymers (poly[2,2″‐((E)‐4,4″‐bis(2‐octyldodecyl)‐[6,6″‐bithieno[3,2‐b]pyrrolylidene]‐5,5″(4 H,4″H)‐dione)‐alt‐2,5‐(thiophene)] (PTS), poly[2,2″‐((E)‐4,4″‐bis(2‐octyldodecyl)‐[6,6″‐bithieno[3,2‐b]pyrrolylidene]‐5,5″(4 H,4″H)‐dione)‐alt‐2,5‐(selenophene)] (PTSe), and poly[2,2″‐((E)‐4,4″‐bis(2‐octyldodecyl)‐[6,6″‐bithieno[3,2‐b]pyrrolylidene]‐5,5″(4 H,4′H)‐dione)‐alt‐2,5‐(tellurophene)] (PTTe)) are synthesized and fully characterized, demonstrating strong absorption in the NIR‐II region. Upon adjusting the chalcogen elements, the intramolecular charge‐transfer characteristics and the heavy‐atom effect are tuned to enhance the intersystem crossing rate, improving the photodynamic effect. Moreover, the energy levels and Gibbs free energies are tuned to facilitate the type‐I photodynamic process. As a result, PTTe nanoparticles (NPs) produce superoxide anion radicals (O 2•−) more efficiently and demonstrate higher photothermal conversion efficiency than PTS and PTSe NPs upon NIR‐II (1064 nm) laser irradiation, exhibiting unprecedented NIR‐II type‐I PDT/PTT performance in vitro and in vivo. This work provides ideas for achieving high‐performance NIR‐II type‐I PDT/PTT semiconducting polymers for hypoxic oncotherapy.
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Ma, H., Peng, Q., An, Z., Huang, W., & Shuai, Z. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11224 · Cited by 613
Self-citationStrategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
Liu, S., Zhang, H., Li, Y., Liu, J., Du, L., Chen, M., Kwok, R. T. K., Lam, J. W. Y., Phillips, D. L., & Tang, B. Z. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201810326 · Cited by 277
Manipulating the Dynamics of Dark Excited States in Organic Materials for Phototheranostics
Hu, W., Prasad, P. N., & Huang, W. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00688 · Cited by 141
Cited by
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Hao, S., Han, H., Yang, Z., Chen, M., Jiang, Y., Lu, G., Dong, L., Wen, H., Li, H., Liu, J., et al. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00901-w · Cited by 280
Li, M., Lu, Z., Zhang, J., Chen, L., Tang, X., Jiang, Q., Hu, Q., Li, L., Liu, J., & Huang, W. (2023) · Advanced Materials · doi:10.1002/adma.202209647 · Cited by 56
Advances on fluorescence bioimaging and photo-mediated therapy of NIR-II small molecule dyes
Zhang, W., Laraib, Huo, F., & Yin, C. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216587 · Cited by 26
Kamya, E., Lu, Z., Cao, Y., & Pei, R. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01903e · Cited by 10
Metadata
- Authors
- Wen, K., Tan, H., Peng, Q., Chen, H., Ma, H., Wang, L., Peng, A., Shi, Q., Cai, X., & Huang, H.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2022-01-05
- Volume
- 34
- Issue
- 7
- Pages
- e2108146-e2108146
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W4200083169
- Cited by
- 298
- References
- 3
- FWCI
- 25.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wen, K., Tan, H., Peng, Q., Chen, H., Ma, H., Wang, L., Peng, A., Shi, Q., Cai, X., & Huang, H. (2022). Achieving Efficient NIR‐II Type‐I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements. Advanced Materials. https://doi.org/10.1002/adma.202108146
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