Tissue engineering: development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition (Adv. Healthcare Mater. 5/2015)
Open accessAbstract
A cellularly degradable hydrogel based on peptide and protein functionalized PEG is designed on page 702 by M. A. Randolph, K. S. Anseth, and co-workers to allow local, cell-mediated remodeling in a manner that promotes cartilage extracellular matrix deposition and leads to increased mechanical properties. The cover depicts encapsulated chondrocytes secreting cartilage-specific matrix macromolecules (orange fibers and green branches) that remodel and replace the surrounding synthetic network (white lines).
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Tissue engineering helps functionalise tissues by mixing scaffolds, cells, and physiologically active chemicals.
“It helps functionalising tissues by mixing scaffolds, cells, and physiologically active chemicals [270,271].”
From Medical 4.0 technologies for healthcare: Features, capabilities, and applications (2022) · cites this paper as [271]
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Medical 4.0 technologies for healthcare: Features, capabilities, and applications
Haleem, A., Javaid, M., Pratap Singh, R., & Suman, R. (2022) · Internet of Things and Cyber-Physical Systems · doi:10.1016/j.iotcps.2022.04.001 · Cited by 468 · see citing works
Functional Hydrogels and Their Application in Drug Delivery, Biosensors, and Tissue Engineering
Wang, K., Hao, Y., Wang, Y., Chen, J., Mao, L., Deng, Y., Chen, J., Yuan, S., Zhang, T., Ren, J., et al. (2019) · International Journal of Polymer Science · doi:10.1155/2019/3160732 · Cited by 86 · see citing works
“Therefore, hydrogels are more similar to living tissues, specifically the outer membrane of the cell matrix, than any other currently known synthetic biomaterials and these properties result in reducing friction and mechanical effects on the surrounding tissues, which significantly improves the biological properties o…”
BackgroundSridhar, B. V., Dailing, E. A., Brock, J. L., Stansbury, J. W., Randolph, M. A., & Anseth, K. S. (2015) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-015-0002-3 · Cited by 29 · see citing works
Self-citationPoormasjedi‐Meibod, M., Pakyari, M., Jackson, J. K., Elizei, S. S., & Ghahary, A. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35770 · Cited by 28 · see citing works
Zhang, Y., Zhang, Y., Zhang, Y., et al. (2016) · Journal of Polymers and the Environment · doi:10.1007/s10924-016-0831-2 · Cited by 17 · see citing works
Wang, Q., Guo, J., Wang, Y., et al. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.01.024 · Cited by 14 · see citing works
Culture of PC12 neuronal cells in GelMA hydrogel for brain tissue engineering
Rifai, N. A., Hasan, A., Kobeissy, F. H., Hasan, A., Rifai, N. A., Gazalah, H., & Charara, J. (2015) · International Conference on Advances in Biomedical Engineering (ICABME) · doi:10.1109/icabme.2015.7323300 · Cited by 11 · see citing works
“The potential impact of this field, has even a broader future: engineered tissues could reduce the need for organ replacement [4], and could greatly accelerate the development of new drugs that may help patients in eliminating the need for organ or transplants.”
BackgroundBiomimetic Tissue Engineering for Musculoskeletal Tissues
Seale, N. M., Zeng, Y., & Varghese, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811467-4.00009-7 · Cited by 5 · see citing works
- Authors
- Sridhar, B. V., Brock, J. L., Silver, J. S., Leight, J. L., Randolph, M. A., & Anseth, K. S.
- Affiliations
- University of Colorado Boulder (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Corresponding author
- Randolph, Mark A.
- Anseth, Kristi S.
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2015-04
- Volume
- 4
- Issue
- 5
- Pages
- 635-635
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2019852491
- Cited by
- 8
- References
- 0
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Advanced Healthcare Materials (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- poly(ethylene glycol) hydrogels, articular cartilage, extracellular matrix deposition, chondrocytes, cartilage tissue engineering, cartilage biomechanics
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