Cited by 218Antimicrobial agents and applicationsBacterial biofilms and quorum sensingNitric Oxide and Endothelin Effects

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Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications

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Yang, Lei, Feura, Evan S., Ahonen, Mona Jasmine R., Schoenfisch, Mark H.·2018·Advanced Healthcare Materials

DOI 10.1002/adhm.201800155PMC PMC6159924

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Abstract

Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO‐releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO‐releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti‐biofilm activity.

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Authors: Yang, L., Feura, E. S., Ahonen, M. J. R., & Schoenfisch, M. H.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Schoenfisch, Mark H.
ORCID: Yang, Lei
Schoenfisch, Mark H.
Venue: Advanced Healthcare Materials
Publisher: Wiley
Published: 2018-05-14
Volume: 7
Issue: 13
Pages: e1800155-e1800155
ISSN: 2192-2640 (ISSN-L)
2192-2659
DOI: 10.1002/adhm.201800155
PMC: PMC6159924
OpenAlex: W2803124751
Cited by: 218
References: 160
Citations by year: 2026: 18 · 2025: 38 · 2024: 38 · 2023: 29 · 2022: 30 · 2021: 31 · 2020: 19 · 2019: 12 · 2018: 2
FWCI: 1.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Advanced Healthcare Materials (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AI112029, DE025207)
Topics: Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: nitric oxide, antibacterial therapeutics, bacterial biofilms, physicochemical properties, antibiotic resistance
MeSH terms: Anti-Bacterial Agents, Humans, Liposomes, Molecular Weight, Nitrates, Nitric Oxide, Polymers, Surface Properties, Biofilms, Nitric Oxide Donors, Macromolecular Substances, Nanoparticles

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Nitric Oxide–Releasing Macromolecular Scaffolds for Antibacterial Applications

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