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Cited by 1,106Antibiotic Use and ResistanceAntibiotic Resistance in BacteriaAntimicrobial Resistance in Staphylococcus

The global threat of antimicrobial resistance: science for intervention.

Open access
Roca, I., Akova, M., Baquero, F., Carlet, J., Cavaleri, M., Coenen, S., Cohen, J., Findlay, D. +16 more·2015·New Microbes and New Infections
DOI 10.1016/j.nmni.2015.02.007PMC PMC4446399
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Abstract

In the last decade we have witnessed a dramatic increase in the proportion and absolute number of bacterial pathogens resistant to multiple antibacterial agents. Multidrug-resistant bacteria are currently considered as an emergent global disease and a major public health problem. The B-Debate meeting brought together renowned experts representing the main stakeholders (i.e. policy makers, public health authorities, regulatory agencies, pharmaceutical companies and the scientific community at large) to review the global threat of antibiotic resistance and come up with a coordinated set of strategies to fight antimicrobial resistance in a multifaceted approach. We summarize the views of the B-Debate participants regarding the current situation of antimicrobial resistance in animals and the food chain, within the community and the healthcare setting as well as the role of the environment and the development of novel diagnostic and therapeutic strategies, providing expert recommendations to tackle the global threat of antimicrobial resistance.

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  • Antibiotic abuse in humans and animals has greatly contributed to an increase in antimicrobial resistance and to environmental accumulation of antibiotics by selecting resistant microorganisms.

    “Antibiotic abuse both in humans and animals has greatly contributed to an increase in AMR and has also caused the accumulation of these compounds in the environment by selecting resistant microorganisms and turning the environment into an enormous reservoir for AMR genes (Roca et al., 2015).”

    From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Roca et al., 2015

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Authors
Roca, I., Akova, M., Baquero, F., Carlet, J., Cavaleri, M., Coenen, S., Cohen, J., Findlay, D., Gyssens, I., Heure, O. E., Kahlmeter, G., Kruse, H., Laxminarayan, R., Liébana, E., López-Cerero, L., MacGowan, A., Martins, M., Rodríguez-Baño, J., Rolain, J.-M., Segovia, C., Sigauque, B., Tacconelli, E., Wellington, E., & Vila, J.
Affiliations
  • Hospital Clínic de Barcelona (ES)
  • European Society of Clinical Microbiology and Infectious Diseases (CH)
  • Instituto Ramón y Cajal de Investigación Sanitaria (ES)
  • Fondation Hôpital Saint-Joseph (FR)
  • European Medicines Agency (NL)
  • University of Antwerp (BE)
  • Brighton and Sussex Medical School (GB)
  • GlaxoSmithKline (United Kingdom) (GB)
  • Radboud University Medical Center (NL)
  • European Centre for Disease Prevention and Control (SE)
  • World Health Organization Regional Office for Europe (DK)
  • Center for Disease Dynamics, Economics & Policy (US)
  • Southmead Hospital (GB)
  • University College Dublin (IE)
  • Inserm (FR)
  • Instituto de Salud Carlos III (ES)
ORCID
Venue
New Microbes and New Infections
Publisher
Elsevier BV
Published
2015-07
Volume
6
Pages
22-29
ISSN
2052-2975 (ISSN-L)
DOI
10.1016/j.nmni.2015.02.007
PMC
PMC4446399
OpenAlex
W2108276360
Cited by
1,106
References
0
Citations by year
2026: 37 · 2025: 70 · 2024: 62 · 2023: 96 · 2022: 115 · 2021: 155 · 2020: 159 · 2019: 133 · 2018: 110 · 2017: 92 · 2016: 61 · 2015: 16
FWCI
8.17
Type
journal article
Language
en
Open access
Licence
Locations
  • New Microbes and New Infections (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by-nc-nd)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
  • Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • idUS (Universidad de Sevilla) (submittedVersion, cc-by-nc-nd)
  • Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders
  • B-Debate (and initiative of Biocat and “la Caixa” Foundation)
  • ISGlobal
  • ESCMID
  • REIPI
  • IMI (Innovation Medicine Initiatives) (115523)
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
antimicrobial resistance, multidrug-resistant bacteria, antibiotic resistance, public health policy, One Health, food chain, zoonotic pathogens, nosocomial infections, environmental transmission, novel therapeutic strategies, expert recommendations

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