A Transferrin Triggered Pathway for Highly Targeted Delivery of Graphene‐Based Nanodrugs to Treat Choroidal Melanoma
Abstract
The synthesis of transferrin (Tf)‐modified pegylated graphene (PG) and its application as a highly efficient drug delivery carrier for therapy of Ocular Choroidal Melanoma‐1 (OCM‐1) cells is presented. For the first reported time, nanoscaled PG is prepared using an environmentally friendly ball‐milling technique. The unique 2D nanostructure obtained using this PG synthesis approach offers considerable advantages in terms of drug loading and delivery, as well as the conjugation of Tf to PG providing a more targeted delivery vehicle. A highly efficient targeted pathway toward OCM‐1 cells triggered by an affinity between Tf and Tf receptors expressed on the surface of OCM‐1 cells is reported first here. PG‐Tf is observed to easily anchor anticancer drugs such as doxorubicin via π–π stacking. This work performs a Transwell two cells coculture experiment, a 3D in vitro tumor model, and an in vivo mouse model with OCM‐1 tumors to demonstrate the composite's therapeutic superiority over conventional systems for the targeted delivery and controlled release of antitumor drugs.
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Transferrin-coupled or covalently linked nanoparticles endow NPs function of targeting tumors, more effectively realize active targeting of drugs, and achieve tumor diagnosis or treatment.
“More studies have also proved that transferrin-coupled or covalently linked nanoparticles endow the NPs function of targeting tumors, which can more effectively realize the active targeting of drugs and achieve the purpose of tumor diagnosis or treatment.272–275”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [274]
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- Authors
- Zhao, B., Dong, K., Lin, M., Dong, G., Shan, S., Lawson, T., Yan, L., Zhang, W., Shi, B., Chou, S., Baker, M. S., & Liu, Y.
- Affiliations
- Wenzhou Medical University (CN)
- Macquarie University (AU)
- University of Wollongong (AU)
- Corresponding author
- Liu, Yong
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2018-06-29
- Volume
- 7
- Issue
- 16
- Pages
- e1800377-e1800377
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W2811428359
- Cited by
- 18
- References
- 41
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2021: 3 · 2020: 5 · 2019: 4
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Funders
- Natural Science Foundation of Zhejiang Province (LR17H180001, LQ16H180003, LY18H180007)
- National Natural Science Foundation of China (21374081, 51433005)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- transferrin, choroidal melanoma, targeted drug delivery, transferrin receptor, ball milling, doxorubicin, π-π stacking, controlled drug release, ocular melanoma, 3D tumor models, mouse tumor model
- MeSH terms
- Animals, Cell Line, Choroid Neoplasms, Graphite, Humans, Melanoma, Transferrin, Drug Delivery Systems, Cell Line, Tumor, Mice
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