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Cited by 412

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation

Mao, Lin, Hu, Sanming, Gao, Yihua, Wang, Li, Zhao, Weiwei, Fu, Lina, Cheng, Haoyan, Xia, Lin, Xie, Shangxian, Ye, Weiliang, Shi, Zhijun, Yang, Guang·2020·Advanced Healthcare Materials

Abstract

Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate skin cell behaviors. Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti 3 C 2 Tx) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES. The composite hydrogel with 2 wt% MXene (rBC/MXene‐2%) exhibits the highest electrical conductivity and the best biocompatibility. Meanwhile, the rBC/MXene‐2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water‐uptake capacity. An in vivo study using a rat full‐thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film. More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non‐ES controls. This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.

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Crossref · 10.1002/adhm.202000872

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Metadata

Authors
Mao, L., Hu, S., Gao, Y., Wang, L., Zhao, W., Fu, L., Cheng, H., Xia, L., Xie, S., Ye, W., Shi, Z., & Yang, G.
Venue
Advanced Healthcare Materials
Publisher
Wiley
Published
2020-08-31
Volume
9
Issue
19
Pages
e2000872-e2000872
ISSN
  • 2192-2640 (ISSN-L)
  • 2192-2659
OpenAlex
W3082875190
Cited by
412
References
60
FWCI
19.38
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation. https://app.cochat.ai/papers/10.1002/adhm.202000872
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Mao, L., Hu, S., Gao, Y., Wang, L., Zhao, W., Fu, L., Cheng, H., Xia, L., Xie, S., Ye, W., Shi, Z., & Yang, G. (2020). Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation. Advanced Healthcare Materials. https://doi.org/10.1002/adhm.202000872

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.