Cited by 142Wound Healing and TreatmentsHydrogels: synthesis, properties, applicationsElectrospun Nanofibers in Biomedical Applications

Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment

Li, Haisheng, Li, Buying, Lv, Dalun, Li, Wenhong, Lu, Yifei, Luo, Gaoxing·2023·Advanced Drug Delivery Reviews

Abstract

Wound healing is characterized by complex, orchestrated, spatiotemporal dynamic processes. Recent findings demonstrated suitable local microenvironments were necessities for wound healing. Wound microenvironments include various biological, biochemical and physical factors, which are produced and regulated by endogenous biomediators, exogenous drugs, and external environment. Successful drug delivery to wound is complicated, and need to overcome the destroyed blood supply, persistent inflammation and enzymes, spatiotemporal requirements of special supplements, and easy deactivation of drugs. Triggered by various factors from wound microenvironment itself or external elements, stimuli-responsive biomaterials have tremendous advantages of precise drug delivery and release. Here, we discuss recent advances of stimuli-responsive biomaterials to regulate local microenvironments during wound healing, emphasizing on the design and application of different biomaterials which respond to wound biological/biochemical microenvironments (ROS, pH, enzymes, glucose and glutathione), physical microenvironments (mechanical force, temperature, light, ultrasound, magnetic and electric field), and the combination modes. Moreover, several novel promising drug carriers (microbiota, metal-organic frameworks and microneedles) are also discussed.

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Crossref · 10.1016/j.addr.2023.114778

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227 of 227 references verified0 citation errors · 0 not checkable

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  • PLCL itself is relatively simple and can only provide a mechanical barrier for wound healing, so it is necessary to further improve the overall performance of the wound dressing by loading other materials or biological factors.

    “However, PLCL itself is relatively simple and can only provide a mechanical barrier for the wound healing process, so it is necessary to further improve the overall performance of the wound dressing by loading other materials or biological factors [141, 142].”

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Authors
Li, H., Li, B., Lv, D., Li, W., Lu, Y., & Luo, G.
Affiliations
  • Army Medical University (CN)
  • First Affiliated Hospital of Wannan Medical College (CN)
Corresponding author
  • Lu, Yifei
  • Luo, Gaoxing
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2023-05
Volume
196
Pages
114778
ISSN
0169-409X (ISSN-L)
OpenAlex
W4324335398
Cited by
142
References
227
Citations by year
2026: 35 · 2025: 53 · 2024: 39 · 2023: 15
FWCI
4.81
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (82002036, SZYZTR02)
  • National Key Research and Development Program of China (2021YFA1101100)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
wound healing, stimuli-responsive biomaterials, drug delivery, wound microenvironment, reactive oxygen species, pH-responsive materials, enzyme-responsive materials, mechanical stimuli, temperature-responsive materials, photoresponsive materials, magnetic field-responsive materials, metal-organic frameworks, microneedles
MeSH terms
Metal-Organic Frameworks, Biocompatible Materials, Drug Carriers, Humans, Wound Healing, Drug Delivery Systems

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