The design of scaffolds for use in tissue engineering. Part I. Traditional factors
Open accessAbstract
In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.
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The limited variation in pore sizes between different LC scaffolds meant these small differences would not influence the degradation effect observed.
“However the limited variation in the pore sizes between different LC scaffolds [69,70] meant these small differences would not influence the degradation effect observed.”
From <i>In vitro</i> degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization (2016) · cites this paper as [70]
The indexed passages on pore sizes (FIG. 3, page unavailable) and degradation (Materials, page unavailable) discuss separate topics. A search for pore-size effects on degradation found no passage addressing LC scaffolds or showing that small pore-size differences would not influence the observed degradation effect. (LLM, conf=0.72)
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- Authors
- Yang, S., Leong, K.-F., Du, Z., & Chua, C.-K.
- Affiliations
- Nanyang Technological University (SG)
- Corresponding author
- Leong, Kah-Fai
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2001-12
- Volume
- 7
- Issue
- 6
- Pages
- 679-689
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W2142720627
- Cited by
- 2,234
- References
- 55
- Citations by year
- 2026: 18 · 2025: 46 · 2024: 56 · 2023: 62 · 2022: 82 · 2021: 84 · 2020: 119 · 2019: 116 · 2018: 123 · 2017: 128 · 2016: 136 · 2015: 146 · 2014: 150 · 2013: 142 · 2012: 132
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Locations
- Tissue Engineering (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- tissue engineering scaffolds, scaffold design, scaffold fabrication techniques, scaffold mechanical properties, scaffold materials, scaffold architecture, tissue regeneration, 3D scaffolds
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Tissue Engineering
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