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Enzymatic Formation of Supramolecular Hydrogels
Abstract
The enzymatic formation of supramolecular hydrogels is reported. A dephosphorylation enzymatic reaction (see Figure) triggers the self-assembly of N-(fluorenyl-methoxycarbonyl) tyrosine and results in hydrogelation at physiological temperatures. This enzymatic gelation process offers opportunities for in-situ generation of hydrogels in tissues and demonstrates potential for biomedical applications of supramolecular hydrogels.
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Citations
Cited by
Bioactive modification of poly (ethylene glycol) hydrogels for tissue engineering
Zhu, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.044 · Cited by 1,457
Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering
Moreira Teixeira, L. S., Feijen, J., van Blitterswijk, C. A., Dijkstra, P. J., & Karperien, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.067 · Cited by 615
Design and Application of Self‐Assembled Low Molecular Weight Hydrogels
de Loos, M., Feringa, B. L., & van Esch, J. H. (2005) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200400723 · Cited by 586
Tao, K., Levin, A., Adler-Abramovich, L., & Gazit, E. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00889a · Cited by 482
Gao, Y., Kuang, Y., Guo, Z.-F., Guo, Z., Krauss, I. J., & Xu, B. (2009) · Journal of the American Chemical Society · doi:10.1021/ja904411z · Cited by 403
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Metadata
- Authors
- Yang, Z., Gu, H., Fu, D., Gao, P., Lam, J. K., & Xu, B.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2004-08-18
- Volume
- 16
- Issue
- 16
- Pages
- 1440-1444
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2135905231
- Cited by
- 602
- References
- 0
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, Z., Gu, H., Fu, D., Gao, P., Lam, J. K., & Xu, B. (2004). Enzymatic Formation of Supramolecular Hydrogels. Advanced Materials. https://doi.org/10.1002/adma.200400340
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
