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Using Graphene Oxide High Near‐Infrared Absorbance for Photothermal Treatment of Alzheimer's Disease
Abstract
A novel strategy to dissociate amyloid aggregation is presented, using localised heat generation from a clinically used amyloid staining dye, thioflavin-S (ThS)-modified graphene oxide (GO) under NIR laser irradiation. Compared to traditional chemotherapies, photothermal therapy shows reduced side effects and improved selectivity and safety.
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In the citing paper
“The second approach—external stimulus-triggered mode switching—employs graphene oxide functionalized with thioflavin-S (ThS).”
From Theranostic Nanoplatforms for Alzheimer's Disease: A Critical Analysis of Conceptual Contradictions (2026) · cites this paper as [30]
In the citing paper
“Continuous diagnostics enable real-time efficacy monitoring while minimizing systemic toxicity [30].”
From Theranostic Nanoplatforms for Alzheimer's Disease: A Critical Analysis of Conceptual Contradictions (2026) · cites this paper as [30]
In the citing paper
“ThS specifically binds amyloid fibrils and fluoresces, providing continuous diagnostic signaling.”
From Theranostic Nanoplatforms for Alzheimer's Disease: A Critical Analysis of Conceptual Contradictions (2026) · cites this paper as [30]
In the citing paper
“Therapeutic action activates via near-infrared (NIR) irradiation: graphene oxide absorbs NIR light, generating localized heat to disassemble fibrils.”
From Theranostic Nanoplatforms for Alzheimer's Disease: A Critical Analysis of Conceptual Contradictions (2026) · cites this paper as [30]
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Metadata
- Authors
- Li, M., Yang, X., Ren, J., Qu, K., & Qu, X.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Qu, Xiaogang
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2012-03-07
- Volume
- 24
- Issue
- 13
- Pages
- 1722-1728
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2005626048
- Cited by
- 535
- References
- 49
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 19 · 2023: 34 · 2022: 37 · 2021: 41 · 2020: 49 · 2019: 49 · 2018: 57 · 2017: 58 · 2016: 45 · 2015: 39 · 2014: 45 · 2013: 37 · 2012: 4
- FWCI
- 22.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Keywords
- graphene oxide, near-infrared photothermal therapy, Alzheimer's disease, amyloid fibril formation, thioflavin S, NIR laser irradiation, amyloid plaques
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Cell Survival, Graphite, Humans, Hyperthermia, Induced, Oxides, Phototherapy, Thiazoles, PC12 Cells, Nanostructures, Mice, Rats, Benzothiazoles
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