The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery
Abstract
Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.
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“In a zebrafish model of methicillin-resistant S. aureus infection, the phosphatase-sensitive nanoparticles enhanced survival by 20 percentage points over free-drug controls.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [60]
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Cites
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Research works printed but not linked: 2
- Deysine M., 1979, Surg. Forum, 30, 38
- Kelly C., 2011, J. Drug Deliv., 727241
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The antimicrobial activity of nanoparticles: present situation and prospects for the future
Wang, L., Hu, C., & Shao, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s121956 · Cited by 4,062
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,674
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,557
Lü, Y., Aimetti, A. A., Langer, R., & Gu, Z. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.75 · Cited by 1,448
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,279
Metadata
- Authors
- Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J.
- Affiliations
- University of Science and Technology of China (CN)
- Corresponding author
- Hu, Bing
- Wang, Jun
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2012-09-10
- Volume
- 24
- Issue
- 46
- Pages
- 6175-6180
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2135595096
- Cited by
- 299
- References
- 49
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 20 · 2023: 22 · 2022: 38 · 2021: 41 · 2020: 31 · 2019: 25 · 2018: 23 · 2017: 25 · 2016: 17 · 2015: 11 · 2014: 14 · 2013: 10
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- targeted antibiotic delivery, enzyme-responsive drug release, polyphosphoesters, macrophage targeting, bacterial infection, bacterial growth inhibition
- MeSH terms
- Nanogels, Animals, Anti-Bacterial Agents, Bacteria, Cell Line, Drug Carriers, Embryo, Nonmammalian, Macrophages, Phagocytosis, Phospholipases, Polyethylene Glycols, Polyethyleneimine, Vancomycin, Zebrafish, Microscopy, Confocal, Mice, Methicillin-Resistant Staphylococcus aureus
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