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Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery
Abstract
Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.
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“In a zebrafish model of methicillin-resistant S. aureus infection, the phosphatase-sensitive nanoparticles enhanced survival by 20 percentage points over free-drug controls.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [60]
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Metadata
- Authors
- Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J.
- Affiliations
- University of Science and Technology of China (CN)
- Corresponding author
- Hu, Bing
- Wang, Jun
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2012-09-10
- Volume
- 24
- Issue
- 46
- Pages
- 6175-6180
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2135595096
- Cited by
- 299
- References
- 49
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 20 · 2023: 22 · 2022: 38 · 2021: 41 · 2020: 31 · 2019: 25 · 2018: 23 · 2017: 25 · 2016: 17 · 2015: 11 · 2014: 14 · 2013: 10
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- targeted antibiotic delivery, enzyme-responsive drug release, polyphosphoesters, macrophage targeting, bacterial infection, bacterial growth inhibition
- MeSH terms
- Nanogels, Animals, Anti-Bacterial Agents, Bacteria, Cell Line, Drug Carriers, Embryo, Nonmammalian, Macrophages, Phagocytosis, Phospholipases, Polyethylene Glycols, Polyethyleneimine, Vancomycin, Zebrafish, Microscopy, Confocal, Mice, Methicillin-Resistant Staphylococcus aureus
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