The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Physical, Chemical, and Biological Structures based on ROS‐Sensitive Moieties that are Able to Respond to Oxidative Microenvironments
Abstract
Reactive oxygen species (ROS) (H 2 O 2, OCl−, •OH, O 2−) are a family of reactive molecules that are generated intracellularly and are engaged in many biological processes. In physiological concentrations, ROS act as signaling molecules to a number of metabolic pathways; however, in excess they can be harmful to living organisms. Overproduction of ROS has been related to many pathophysiological conditions and a number of studies have been reported in elucidating their mechanism in these conditions. With the aim of harnessing this role, a number of imaging tools and therapeutic compounds have been developed. Here these imaging and therapeutic tools are reviewed and particularly those structures with ROS‐sensitivity based on their biomedical applications and their functional groups. There is also a brief discussion about the method of preparation as well as the mechanism of action.
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Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Chemistry and biology of reactive oxygen species in signaling or stress responses
Dickinson, B. C., & Chang, C. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.607 · Cited by 1,821
Redox-responsive polymers for drug delivery: from molecular design to applications
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Molecular imaging of hydrogen peroxide produced for cell signaling
Miller, E. W., Tulyathan, O., Isacoff, E. Y., & Chang, C. J. (2007) · Nature Chemical Biology · doi:10.1038/nchembio871 · Cited by 450
Cited by
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
Zhou, Z., Song, J., Nie, L., & Chen, X. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00271d · Cited by 2,098
Hu, J., Jiang, W., Yuan, L., Duan, C., Yuan, Q., Long, Z., Lou, X., & Xia, F. (2021) · Aggregate · doi:10.1002/agt2.10 · Cited by 172
ROS-Activated Ratiometric Fluorescent Polymeric Nanoparticles for Self-Reporting Drug Delivery
Zhang, M., Song, C.-C., Su, S., Du, F.-S., & Li, Z.-C. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18438 · Cited by 64
Metadata
- Authors
- Tapeinos, C., & Pandit, A.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2016-05-17
- Volume
- 28
- Issue
- 27
- Pages
- 5553-5585
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2396166154
- Cited by
- 237
- References
- 5
- FWCI
- 14.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tapeinos, C., & Pandit, A. (2016). Physical, Chemical, and Biological Structures based on ROS‐Sensitive Moieties that are Able to Respond to Oxidative Microenvironments. Advanced Materials. https://doi.org/10.1002/adma.201505376
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