Cited by 561Nanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applicationsAdvanced Polymer Synthesis and Characterization

Redox-responsive polymers for drug delivery: from molecular design to applications

Huo, Meng, Yuan, Jinying, Tao, Lei, Wei, Yen·2014·Polym. Chem.

Abstract

Glutathione has been regarded as a significant signal for distinguishing between tumor and normal tissue. Recently, reactive oxygen species have attracted much attention for their close connection with many diseases. Taking advantage of the physiological signals, redox-responsive polymeric drug carriers constitute a significant research area in the various stimuli-responsive polymers for biomedical applications. During the rapid development of redox-responsive polymers, molecular design and related synthetic methodology plays a crucial role. In this review, we discuss the reduction- and oxidation-responsive polymeric drug carriers from the view of functional groups, as well as their applications in controlled release.

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Crossref · 10.1039/c3py01192e

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123 of 123 references verified0 citation errors · 0 not checkable

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  • Many redox-responsive nanoparticles have been investigated for the delivery of chemotherapeutic drugs to treat cancer, including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.

    “For the delivery of chemotherapeutic drugs to treat cancer, many redox-responsive nanoparticles have been investigated recently,166 including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.167,168”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [166]

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Authors
Huo, M., Yuan, J., Tao, L., & Wei, Y.
Affiliations
Tsinghua University (CN)
Corresponding author
  • Yuan, Jinying
  • Wei, Yen
Venue
Polym. Chem.
Published
2014
Volume
5
Issue
5
Pages
1519-1528
ISSN
  • 1759-9954 (ISSN-L)
  • 1759-9962
OpenAlex
W2127651098
Cited by
561
References
123
Citations by year
2026: 11 · 2025: 26 · 2024: 28 · 2023: 36 · 2022: 37 · 2021: 52 · 2020: 54 · 2019: 49 · 2018: 82 · 2017: 46 · 2016: 61 · 2015: 51 · 2014: 26
FWCI
17.55
Type
journal article
Language
en
Open access
closed
Locations
Polymer Chemistry (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • National Key Research and Development Program of China
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
redox-responsive polymers, stimuli-responsive polymers, polymeric drug carriers, reactive oxygen species, controlled drug release, polymer molecular design, polymer synthesis

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