Redox-responsive polymers for drug delivery: from molecular design to applications
Abstract
Glutathione has been regarded as a significant signal for distinguishing between tumor and normal tissue. Recently, reactive oxygen species have attracted much attention for their close connection with many diseases. Taking advantage of the physiological signals, redox-responsive polymeric drug carriers constitute a significant research area in the various stimuli-responsive polymers for biomedical applications. During the rapid development of redox-responsive polymers, molecular design and related synthetic methodology plays a crucial role. In this review, we discuss the reduction- and oxidation-responsive polymeric drug carriers from the view of functional groups, as well as their applications in controlled release.
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Many redox-responsive nanoparticles have been investigated for the delivery of chemotherapeutic drugs to treat cancer, including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.
“For the delivery of chemotherapeutic drugs to treat cancer, many redox-responsive nanoparticles have been investigated recently,166 including polymers, micelles, MSNs, siRNA, proteins, and liposomes for the controlled delivery system in cancer therapy.167,168”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [166]
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Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070 · see citing works
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Dai, Y., Chen, X., & Zhang, X. (2019) · Polymer Chemistry · doi:10.1039/c8py01174e · Cited by 87 · see citing works
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- Authors
- Huo, M., Yuan, J., Tao, L., & Wei, Y.
- Affiliations
- Tsinghua University (CN)
- Corresponding author
- Yuan, Jinying
- Wei, Yen
- Venue
- Polym. Chem.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 5
- Issue
- 5
- Pages
- 1519-1528
- ISSN
- 1759-9954 (ISSN-L)
- 1759-9962
- OpenAlex
- W2127651098
- Cited by
- 561
- References
- 123
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 28 · 2023: 36 · 2022: 37 · 2021: 52 · 2020: 54 · 2019: 49 · 2018: 82 · 2017: 46 · 2016: 61 · 2015: 51 · 2014: 26
- FWCI
- 17.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Polymer Chemistry (publishedVersion)
- Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- redox-responsive polymers, stimuli-responsive polymers, polymeric drug carriers, reactive oxygen species, controlled drug release, polymer molecular design, polymer synthesis
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