The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Tumor Microenvironment‐Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy
Open accessAbstract
The efficacy of photosensitizers in cancer phototherapy is often limited by photobleaching, low tumor selectivity, and tumor hypoxia. Assembling photosensitizers into nanostructures can improve photodynamic therapy efficacy and the safety profile of photosensitizers. Herein by employing supramolecular assembly, enhanced theranostic capability of Mn 2+‐assisted assembly of a photosensitizer (sinoporphyrin sodium, DVDMS) is demonstrated. A tumor environment‐triggered coassembly strategy is further developed to form Mn/DVDMS nanotheranostics (nanoDVD) for cancer phototherapy. MnO 2 nanosheets serve as a highly effective DVDMS carrier and in situ oxygen and nanoDVD generator. In MCF‐7 cells and xenograft tumors, MnO 2/DVDMS is reduced by glutathione (GSH) and H 2 O 2 and reassembled into nanoDVD, which can be monitored by activated magnetic resonance/fluorescence/photoacoustic signals. Intriguingly, the decrease of GSH, the production of O 2, and the formation of nanoDVD are shown to be synergistic with phototherapy to improve antitumor efficacy in vitro and in vivo, offering a new avenue for cancer theranostics.
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Cited by
Supramolecular photosensitizers rejuvenate photodynamic therapy
Li, X., Lee, S., & Yoon, J. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00594f · Cited by 1,114
Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy
Lin, H., Chen, Y., & Shi, J. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00471k · Cited by 803
Self-citationMetal–Organic Framework‐Based Stimuli‐Responsive Systems for Drug Delivery
Cai, W., Wang, J., Chu, C., Chen, W., Wu, C., & Liu, G. (2019) · Advanced Science · doi:10.1002/advs.201801526 · Cited by 744
Self-citationConquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
Ding, B., Zheng, P., Ma, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.201905823 · Cited by 521
Metadata
- Authors
- Chu, C., Lin, H., Liu, H., Wang, X., Wang, J., Zhang, P., Gao, H., Huang, C., Zeng, Y., Tan, Y., Liu, G., & Chen, X.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-04-18
- Volume
- 29
- Issue
- 23
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2606777299
- Cited by
- 256
- References
- 30
- FWCI
- 16.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Chu, C., Lin, H., Liu, H., Wang, X., Wang, J., Zhang, P., Gao, H., Huang, C., Zeng, Y., Tan, Y., Liu, G., & Chen, X. (2017). Tumor Microenvironment‐Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy. Advanced Materials. https://doi.org/10.1002/adma.201605928
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