The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Red Blood Cells for Glucose‐Responsive Insulin Delivery
Open accessAbstract
Glucose‐responsive delivery of insulin mimicking the function of pancreatic β‐cells to achieve meticulous control of blood glucose (BG) would revolutionize diabetes care. Here the authors report the development of a new glucose‐responsive insulin delivery system based on the potential interaction between the glucose derivative‐modified insulin (Glc‐Insulin) and glucose transporters on erythrocytes (or red blood cells, RBCs) membrane. After being conjugated with the glucosamine, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of BG level in vivo. The delivery vehicle can be further simplified utilizing injectable polymeric nanocarriers coated with RBC membrane and loaded with Glc‐Insulin. The described work is the first demonstration of utilizing RBC membrane to achieve smart insulin delivery with fast responsiveness.
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Cites
Global estimates of diabetes prevalence for 2013 and projections for 2035
Guariguata, L., Whiting, D. R., Hambleton, I., Beagley, J., Linnenkamp, U., & Shaw, J. E. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.11.002 · Cited by 4,642
Cited by
Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
Yu, J., Wang, J., Zhang, Y., Chen, G., Mao, W., Ye, Y., Kahkoska, A. R., Buse, J. B., Langer, R., & Gu, Z. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0508-y · Cited by 604
Self-citationRecent advances in selective photothermal therapy of tumor
Zhao, L., Zhang, X., Wang, X., Guan, X., Zhang, W., & Ma, J. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01080-3 · Cited by 445
Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery
Wang, J., Ye, Y., Yu, J., Kahkoska, A. R., Zhang, X., Wang, C., Sun, W., Corder, R. D., Chen, Z., Khan, S. A., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b08152 · Cited by 299
Self-citationWang, J., Wang, Z., Yu, J., Zhang, Y., Zeng, Y., & Gu, Z. (2019) · Biomaterials Science · doi:10.1039/c9bm01283d · Cited by 21
Self-citationRecent Progress in Glucose-Responsive Insulin
Liu, Y., Wang, S., Wang, Z., Yu, J., Wang, J., Buse, J. B., & Gu, Z. (2024) · Diabetes · doi:10.2337/dbi23-0028 · Cited by 19
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Metadata
- Authors
- Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., Buse, J. B., & Gu, Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-03-07
- Volume
- 29
- Issue
- 18
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2593743356
- Cited by
- 169
- References
- 1
- FWCI
- 7.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., Buse, J. B., & Gu, Z. (2017). Red Blood Cells for Glucose‐Responsive Insulin Delivery. Advanced Materials. https://doi.org/10.1002/adma.201606617
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