The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Precise Two‐Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation‐Induced Emission Characteristics
Abstract
Two‐photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two‐photon absorption (TPA) cross section, high reactive‐oxygen‐species (ROS) generation efficiency, and bright two‐photon fluorescence. Here, an effective photosensitizer with aggregation‐induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two‐photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two‐photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two‐photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain‐blood‐vessel closure as examples. This shows therapy precision up to 5 µm under two‐photon excitation.
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Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
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Self-citationThe present and future role of photodynamic therapy in cancer treatment
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
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Self-citationAggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications
Cai, X., & Liu, B. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000845 · Cited by 796
Self-citationAggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
The fast-growing field of photo-driven theranostics based on aggregation-induced emission
Zhang, Z., Kang, M., Tan, H., Song, N., Li, M., Xiao, P., Yan, D., Zhang, L., Wang, D., & Tang, B. Z. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01138c · Cited by 374
Metadata
- Authors
- Gu, B., Wu, W., Xu, G., Feng, G., Yin, F., Chong, P. H. J., Qu, J., Yong, K., & Liu, B.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-05-26
- Volume
- 29
- Issue
- 28
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2617683824
- Cited by
- 308
- References
- 37
- FWCI
- 30.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gu, B., Wu, W., Xu, G., Feng, G., Yin, F., Chong, P. H. J., Qu, J., Yong, K., & Liu, B. (2017). Precise Two‐Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation‐Induced Emission Characteristics. Advanced Materials. https://doi.org/10.1002/adma.201701076
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