The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis
Abstract
Skin interstitial fluid (ISF) is an emerging source of biomarkers for disease diagnosis and prognosis. Microneedle (MN) patch has been identified as an ideal platform to extract ISF from the skin due to its pain‐free and easy‐to‐administrated properties. However, long sampling time is still a serious problem which impedes timely metabolic analysis. In this study, a swellable MN patch that can rapidly extract ISF is developed. The MN patch is made of methacrylated hyaluronic acid (MeHA) and further crosslinked through UV irradiation. Owing to the supreme water affinity of MeHA, this MN patch can extract sufficient ISF in a short time without the assistance of extra devices, which remarkably facilitates timely metabolic analysis. Due to covalent crosslinked network, the MN patch maintains the structure integrity in the swelling hydrated state without leaving residues in skin after usage. More importantly, the extracted ISF metabolites can be efficiently recovered from MN patch by centrifugation for the subsequent offline analysis of metabolites such as glucose and cholesterol. Given the recent trend of easy‐to‐use point‐of‐care devices for personal healthcare monitoring, this study opens a new avenue for the development of MN‐based microdevices for sampling ISF and minimally invasive metabolic detection.
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Cites
Hyaluronan: from extracellular glue to pericellular cue
Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843
Rebrin, K., Sheppard, N. F., & Steil, G. M. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400507 · Cited by 152
Cited by
Aldawood, F. K., Andar, A., & Desai, S. (2021) · Polymers · doi:10.3390/polym13162815 · Cited by 499
Wearable Electrochemical Sensors for the Monitoring and Screening of Drugs
Teymourian, H., Parrilla, M., Sempionatto, J. R., Montiel, N. F., Barfidokht, A., Van Echelpoel, R., De Wael, K., & Wang, J. (2020) · ACS Sensors · doi:10.1021/acssensors.0c01318 · Cited by 423
Recent Advances in Photo-Crosslinkable Hydrogels for Biomedical Applications
Choi, J. R., Yong, K. W., Choi, J. Y., & Cowie, A. C. (2019) · BioTechniques · doi:10.2144/btn-2018-0083 · Cited by 403
Mechanisms of sampling interstitial fluid from skin using a microneedle patch
Samant, P. P., & Prausnitz, M. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716772115 · Cited by 363
Lab under the Skin: Microneedle Based Wearable Devices
Teymourian, H., Tehrani, F., Mahato, K., & Wang, J. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002255 · Cited by 310
Metadata
- Authors
- Chang, H., Zheng, M., Yu, X., Than, A., Seeni, R. Z., Kang, R., Tian, J., Khanh, D. P., Liu, L., Chen, P., & Xu, C.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-07-17
- Volume
- 29
- Issue
- 37
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2734891260
- Cited by
- 462
- References
- 3
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chang, H., Zheng, M., Yu, X., Than, A., Seeni, R. Z., Kang, R., Tian, J., Khanh, D. P., Liu, L., Chen, P., & Xu, C. (2017). A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis. Advanced Materials. https://doi.org/10.1002/adma.201702243
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