The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Tumor‐Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers
Abstract
A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation of β‐lapachone and a reactive‐oxygen‐species (ROS)‐responsive doxorubicin (DOX) prodrug, BDOX, in polymeric nanoparticles. Releasing β‐lapachone first from the CARNs selectively increases the ROS level in cancer cells via NAD(P)H:quinone oxidoreductase‐1 (NQO1) catalysis, which induces the cascade amplification release of DOX and overcomes multidrug resistance (MDR) in cancer cells, producing a remarkably improved therapeutic efficacy against MDR tumors with minimal side effects.
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Citations
Cites
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Maeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.002 · Cited by 2,376
The role of micelle size in tumor accumulation, penetration, and treatment
Wang, J., Mao, W., Lock, L. L., Tang, J., Sui, M., Sun, W., Cui, H., Xu, D., & Shen, Y. (2015) · ACS Nano · doi:10.1021/acsnano.5b02017 · Cited by 635
Self-citation
Cited by
Wang, S., Wang, Z., Yu, G., Zhou, Z., Jacobson, O., Liu, Y., Ma, Y., Zhang, F., Chen, Z., & Chen, X. (2019) · Advanced Science · doi:10.1002/advs.201801986 · Cited by 292
Self-citationMa, W., Mao, J., Yang, X., Pan, C., Chen, W., Wang, M., Yu, P., Mao, L., & Li, Y. (2019) · Chemical Communications · doi:10.1039/c8cc08116f · Cited by 283
Tumor target amplification: Implications for nano drug delivery systems
Seidi, K., Neubauer, H. A., Moriggl, R., Jahanban-Esfahlan, R., & Javaheri, T. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.020 · Cited by 145
Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy
Liao, J., Jia, Y., Wu, Y., Shi, K., Yang, D., Li, P., & Qian, Z. (2020) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1581 · Cited by 67
Cyclic RGD-Functionalized pH/ROS Dual-Responsive Nanoparticle for Targeted Breast Cancer Therapy
Yao, P., Wang, X., Wang, Q., Dai, Q., Peng, Y., Yuan, Q., Mou, N., Lv, S., Weng, B., Wang, Y., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071827 · Cited by 22
Metadata
- Authors
- Ye, M., Han, Y., Tang, J., Piao, Y., Liu, X., Zhou, Z., Gao, J., Rao, J., & Shen, Y.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-08-21
- Volume
- 29
- Issue
- 38
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2746817330
- Cited by
- 338
- References
- 4
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ye, M., Han, Y., Tang, J., Piao, Y., Liu, X., Zhou, Z., Gao, J., Rao, J., & Shen, Y. (2017). A Tumor‐Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers. Advanced Materials. https://doi.org/10.1002/adma.201702342
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