Physical‐, chemical‐, and biological‐responsive nanomedicine for cancer therapy

Stimuli-responsive nanocarriers for drug delivery

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Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

Progress and challenges towards targeted delivery of cancer therapeutics

Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220 · see citing works

Controlled drug delivery vehicles for cancer treatment and their performance

Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167 · see citing works

Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats

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Untitled work

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The emerging nanomedicine landscape

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Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works

Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery

Cheng, R., Feng, F., Meng, F., Deng, C., Feijén, J., & Zhong, Z. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.030 · Cited by 1,367 · see citing works

Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery

Cheng, R., Meng, F., Deng, C., Klok, H., & Zhong, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.084 · Cited by 1,356 · see citing works

Acidic extracellular microenvironment and cancer

Kato, Y., Ozawa, S., Miyamoto, C., Maehata, Y., Suzuki, A., Maeda, T., & Baba, Y. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-89 · Cited by 1,295 · see citing works

Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

Du, J., Du, X., Mao, C., & Wang, J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207150n · Cited by 1,177 · see citing works

Rethinking cancer nanotheranostics

Chen, H., Zhang, W., Zhu, G., Xie, J., & Chen, X. S. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.24 · Cited by 1,107 · see citing works

The big picture on nanomedicine: the state of investigational and approved nanomedicine products

Etheridge, M. L., Campbell, S. A., Erdman, A. G., Haynes, C. L., Wolf, S. M., & McCullough, J. (2013) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.05.013 · Cited by 1,088 · see citing works

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Dai, Y., Xu, C., Sun, X., & Chen, X. S. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00592f · Cited by 931 · see citing works

Clinical Translation of Nanomedicine

Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00116 · Cited by 795 · see citing works

Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation

Hoffman, A. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.11.004 · Cited by 763 · see citing works

Smart polymers for the controlled delivery of drugs – a concise overview

James, H. P., John, R., Alex, A., & Anoop, K. R. (2014) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2014.02.005 · Cited by 594 · see citing works

Stimuli‐responsive liposomes for drug delivery

Lee, Y. R., & Thompson, D. H. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1450 · Cited by 586 · see citing works

Near‐Infrared‐Light‐Activatable Nanomaterial‐Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment

Vankayala, R., & Hwang, K. C. (2018) · Advanced Materials · doi:10.1002/adma.201706320 · Cited by 557 · see citing works

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Kemp, J. A., Shim, M. S., Heo, C. Y., & Kwon, Y. J. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.019 · Cited by 508 · see citing works

The acidic tumor microenvironment: a target for smart cancer nano-theranostics

Feng, L., Dong, Z., Tao, D., Zhang, Y., & Liu, Z. (2017) · National Science Review · doi:10.1093/nsr/nwx062 · Cited by 428 · see citing works

Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications

Shim, M. S., & Kwon, Y. J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.018 · Cited by 384 · see citing works

Nanoscale Metal–Organic Particles with Rapid Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy

Yang, Y. P., Liu, J., Liang, C., Feng, L., Fu, T., Dong, Z., Chao, Y., Li, Y., Lu, G. M., Chen, M., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b07882 · Cited by 342 · see citing works

A Tumor‐Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers

Ye, M., Han, Y., Tang, J., Piao, Y., Liu, X., Zhou, Z., Gao, J., Rao, J., & Shen, Y. (2017) · Advanced Materials · doi:10.1002/adma.201702342 · Cited by 338 · see citing works

Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

Xuan, M., Shao, J., Zhao, J., Li, Q., Dai, L., & Li, J. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201712996 · Cited by 307 · see citing works

Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications

Liu, F., He, X., Chen, H., Zhang, J., Zhang, H., & Wang, Z. (2015) · Nature Communications · doi:10.1038/ncomms9003 · Cited by 295 · see citing works

Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor

Wang, T., Wang, D., Yu, H., Wang, M., Liu, J., Feng, B., Zhou, F., Yin, Q., Zhang, Z., Huang, Y., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b07706 · Cited by 294 · see citing works

Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy

Hu, C., Cun, X., Ruan, S., Liu, R., Xiao, W., Yang, X., Yang, Y., Yang, C., & Gao, H. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.046 · Cited by 277 · see citing works

Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles To Overcome Delivery Barriers in Cancer Nanomedicine

Du, J., Li, H., & Wang, J. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00195 · Cited by 277 · see citing works

ROS-induced NO generation for gas therapy and sensitizing photodynamic therapy of tumor

Wan, S., Zeng, J., Cheng, H. L., & Zhang, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.004 · Cited by 273 · see citing works

Targeting Vacuolar H+-ATPases as a New Strategy against Cancer

Fais, S., Milito, A. D., You, H., & Qin, W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1805 · Cited by 264 · see citing works

Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy

Liu, D., Poon, C. J., Lu, K., He, C., & Lin, W. (2014) · Nature Communications · doi:10.1038/ncomms5182 · Cited by 251 · see citing works

Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy

Zhao, X., Yang, C., Chen, L., & Yan, X. (2017) · Nature Communications · doi:10.1038/ncomms14998 · Cited by 249 · see citing works

Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy

Jia, X., Zhang, Y., Zou, Y., Wang, Y., Niu, D., He, Q., Huang, Z., Zhu, W., Tian, H., Shi, J., et al. (2018) · Advanced Materials · doi:10.1002/adma.201704490 · Cited by 232 · see citing works

Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound

Cao, Y., Chen, Y., Yu, T., Guo, Y., Liu, F., Yao, Y., Li, P., Wang, D., Wang, Z., Chen, Y., et al. (2018) · Theranostics · doi:10.7150/thno.21492 · Cited by 229 · see citing works

Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

Hayashi, K., Nakamura, M., Miki, H., Ozaki, S., Abe, M., Matsumoto, T., Sakamoto, W., Yogo, T., & Ishimura, K. (2014) · Theranostics · doi:10.7150/thno.9199 · Cited by 220 · see citing works

Albumin-NIR dye self-assembled nanoparticles for photoacoustic pH imaging and pH-responsive photothermal therapy effective for large tumors

Chen, Q., Liu, X., Zeng, J., Cheng, Z., & Liu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.041 · Cited by 214 · see citing works

Tumor-Targeting and Microenvironment-Responsive Smart Nanoparticles for Combination Therapy of Antiangiogenesis and Apoptosis

Huang, S., Shao, K., Liu, Y., Kuang, Y., Li, J., An, S., Guo, Y., Ma, H., & Jiang, C. (2013) · ACS Nano · doi:10.1021/nn400548g · Cited by 213 · see citing works

Oxygen-generating Hybrid Polymeric Nanoparticles with Encapsulated Doxorubicin and Chlorin e6 for Trimodal Imaging-Guided Combined Chemo-Photodynamic Therapy

Hu, D., Chen, L., Qu, Y., Peng, J., Chu, B., Shi, K., Hao, Y., Zhong, L. X., Wang, M., & Qian, Z. (2018) · Theranostics · doi:10.7150/thno.22989 · Cited by 212 · see citing works

NIR‐Responsive On‐Demand Release of CO from Metal Carbonyl‐Caged Graphene Oxide Nanomedicine

He, Q., Kiesewetter, D. O., Qu, Y., Fu, X., Fan, J., Huang, P., Liu, Y., Zhu, G., Liu, Y., Qian, Z., et al. (2015) · Advanced Materials · doi:10.1002/adma.201502762 · Cited by 211 · see citing works

Nanoscale theranostics for physical stimulus-responsive cancer therapies

Chen, Q., Ke, H., Dai, Z., & Liu, Z. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.018 · Cited by 209 · see citing works

Combined Cancer Photothermal-Chemotherapy Based on Doxorubicin/Gold Nanorod-Loaded Polymersomes

Liao, J., Li, W., Peng, J., Yang, Q., Li, H., Wei, Y., Zhang, X., & Qian, Z. (2015) · Theranostics · doi:10.7150/thno.10731 · Cited by 192 · see citing works

Tumor microenvironment: Interactions and therapy

Najafi, M., Goradel, N. H., Farhood, B., Salehi, E., Solhjoo, S., Toolee, H., Kharazinejad, E., & Mortezaee, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27425 · Cited by 185 · see citing works

Highly reactive oxygen species: detection, formation, and possible functions

Freinbichler, W., Colivicchi, M. A., Stefanini, C., Bianchi, L., Ballini, C., Misini, B., Weinberger, P., Linert, W., Varešlija, D., Tipton, K. F., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0682-x · Cited by 182 · see citing works

Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient‐Derived Lung Cancer

Cong, Y., Xiao, H., Xiong, H., Wang, Z., Ding, J., Li, C., Chen, X., Liang, X., Zhou, D., & Huang, Y. (2018) · Advanced Materials · doi:10.1002/adma.201706220 · Cited by 179 · see citing works

Cucurbit[7]uril Enables Multi-Stimuli-Responsive Release from the Self-Assembled Hydrophobic Phase of a Metal Organic Polyhedron

Samanta, S. K., Quigley, J., Vinciguerra, B., Briken, V., & Isaacs, L. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b05154 · Cited by 177 · see citing works

Nanosystems Based on Magnetic Nanoparticles and Thermo- or pH-Responsive Polymers: An Update and Future Perspectives

Binh, T., Fernandes, S., Balakrishnan, P. B., & Pellegrino, T. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00549 · Cited by 176 · see citing works

Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography

Feng, Q., Zhang, Y., Zhang, W., Shan, X., Yuan, Y., Zhang, H., Hou, L., & Zhang, Z. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.04.024 · Cited by 175 · see citing works

Stimuli‐Responsive Polymeric Nanoparticles for Nanomedicine

Crucho, C. I. C. (2014) · ChemMedChem · doi:10.1002/cmdc.201402290 · Cited by 174 · see citing works

Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle

Qin, Y., Chen, J., Bi, Y., Xu, X., Zhou, H. D., Gao, J., Hu, Y., Zhao, Y., & Chai, Z. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.01.026 · Cited by 171 · see citing works

pH and Redox Dual Responsive Nanoparticle for Nuclear Targeted Drug Delivery

Remant Bahadur, K. C., Thapa, B., & Xu, P. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300274g · Cited by 162 · see citing works

Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors

Wang, T., Wang, D., Liu, J., Feng, B., Zhou, F., Zhang, H., Zhou, L., Yin, Q., Zhang, Z., Cao, Z., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b02031 · Cited by 162 · see citing works

Ultrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug delivery

Yu, L., Chen, Y., Lin, H., Du, W., Chen, H., & Shi, J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.01.046 · Cited by 160 · see citing works

Ultrasound Triggered Conversion of Porphyrin/Camptothecin-Fluoroxyuridine Triad Microbubbles into Nanoparticles Overcomes Multidrug Resistance in Colorectal Cancer

Chen, M., Liang, X., Gao, C., Zhao, R., Zhang, N., Wang, S., Chen, W., Zhao, B., Wang, J., & Dai, Z. (2018) · ACS Nano · doi:10.1021/acsnano.8b03674 · Cited by 159 · see citing works

NIR‐Activated Polydopamine‐Coated Carrier‐Free “Nanobomb” for In Situ On‐Demand Drug Release

Li, M., Sun, X., Zhang, N., Wang, W., Yang, Y., Jia, H., & Liu, W. (2018) · Advanced Science · doi:10.1002/advs.201800155 · Cited by 153 · see citing works

MRI-guided and ultrasound-triggered release of NO by advanced nanomedicine

Jin, Z., Wen, Y., Hu, Y., Chen, W., Zheng, X., Guo, W., Wang, T., Qian, Z., Su, B., & He, Q. (2017) · Nanoscale · doi:10.1039/c7nr00231a · Cited by 152 · see citing works

Theranostic Gold Nanomicelles made from Biocompatible Comb‐like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance

Deng, H., Dai, F., Ma, G., & Zhang, X. (2015) · Advanced Materials · doi:10.1002/adma.201501420 · Cited by 151 · see citing works

Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

Wagner, A. M., Gran, M. P., & Peppas, N. A. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.01.013 · Cited by 149 · see citing works

Stimuli-responsive polymersomes for cancer therapy

Thambi, T., Park, J. H., & Lee, D. S. (2015) · Biomaterials Science · doi:10.1039/c5bm00268k · Cited by 148 · see citing works

Synthesis, functionalization, and nanomedical applications of functional magnetic nanoparticles

Zhou, C., Wu, C., Zhang, Z., Wu, W., Wang, X., & Yu, Z. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2018.08.007 · Cited by 148 · see citing works

Intratumoral H 2 O 2 -triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

Jin, Z., Wen, Y., Xiong, L., Yang, T., Zhao, P., Tan, L., Wang, T., Qian, Z., Su, B., & He, Q. (2017) · Chemical Communications · doi:10.1039/c7cc01576c · Cited by 147 · see citing works

Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy

Tang, X., Tan, L., Shi, K., Peng, J., Xiao, Y., Li, W., Chen, L., Yang, Q., & Qian, Z. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.05.011 · Cited by 147 · see citing works

Beyond Traditional Hyperthermia: In Vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers

Guisasola, E., Asín, L., Beola, L., de la Fuente, J. M., Baeza, A., & Vallet‐Regí, M. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b02398 · Cited by 146 · see citing works

Stimuli-responsive polymers for anti-cancer drug delivery

Cheng, W., Gu, L., Ren, W., & Liu, Y. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.05.050 · Cited by 144 · see citing works

Reduced graphene oxide (rGO) hybridized hydrogel as a near-infrared (NIR)/pH dual-responsive platform for combined chemo-photothermal therapy

Liu, W., Zhang, X., Zhou, L. M., Shang, L., & Su, Z. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.10.050 · Cited by 142 · see citing works

Hypoxia-responsive lipid-poly-(hypoxic radiosensitized polyprodrug) nanoparticles for glioma chemo- and radiotherapy

Hua, L., Wang, Z., Zhao, L., Mao, H., Wang, G., Zhang, K., Liu, X., Wu, D., Zheng, Y., Lu, J. L., et al. (2018) · Theranostics · doi:10.7150/thno.26225 · Cited by 142 · see citing works

Glutathione- and pH-responsive nonporous silica prodrug nanoparticles for controlled release and cancer therapy

Xu, Z., Liu, S., Kang, Y., & Wang, M. (2015) · Nanoscale · doi:10.1039/c5nr00297d · Cited by 139 · see citing works

Novel Approach of Using Near-Infrared Responsive PEGylated Gold Nanorod Coated Poly( l -lactide) Microneedles to Enhance the Antitumor Efficiency of Docetaxel-Loaded MPEG-PDLLA Micelles for Treating an A431 Tumor

Hao, Y., Dong, M., Zhang, T., Peng, J., Jia, Y., Cao, Y., & Qian, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03604 · Cited by 139 · see citing works

Stimuli-responsive cancer therapy based on nanoparticles

Yu, J. X., Chu, X., & Hou, Y. (2014) · Chemical Communications · doi:10.1039/c4cc03984j · Cited by 134 · see citing works

Trigger responsive polymeric nanocarriers for cancer therapy

Kaur, S., Prasad, C., Balakrishnan, B., & Banerjee, R. (2015) · Biomaterials Science · doi:10.1039/c5bm00002e · Cited by 132 · see citing works

Erythrocyte-Membrane-Coated Prussian Blue/Manganese Dioxide Nanoparticles as H2O2-Responsive Oxygen Generators To Enhance Cancer Chemotherapy/Photothermal Therapy

Peng, J., Yang, Q., Li, W., Tan, L., Xiao, Y., Chen, L., Hao, Y., & Qian, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17022 · Cited by 131 · see citing works

Porous Au@Pt Nanoparticles: Therapeutic Platform for Tumor Chemo-Photothermal Co-Therapy and Alleviating Doxorubicin-Induced Oxidative Damage

Yang, Q., Peng, J., Xiao, Y., Li, W., Tan, L., Xu, X., & Qian, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b14705 · Cited by 130 · see citing works

Controlled release of cisplatin from pH-thermal dual responsive nanogels

Peng, J., Qi, T., Liao, J., Chu, B., Yang, Q., Li, W., Qu, Y., Luo, F., & Qian, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.092 · Cited by 127 · see citing works

Biodegradation and Toxicity of Protease/Redox/pH Stimuli-Responsive PEGlated PMAA Nanohydrogels for Targeting Drug delivery

Jin, S., Wan, J., Meng, L., Huang, X., Guo, J., Liu, L., & Wang, C. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b05984 · Cited by 126 · see citing works

Photo, pH, and thermo triple-responsive spiropyran-based copolymer nanoparticles for controlled release

Chen, S., Jiang, F., Cao, Z., Wang, G., & Dang, Z. (2015) · Chemical Communications · doi:10.1039/c5cc04087f · Cited by 126 · see citing works

NIR-controlled morphology transformation and pulsatile drug delivery based on multifunctional phototheranostic nanoparticles for photoacoustic imaging-guided photothermal-chemotherapy

Yang, J., Zhai, S., Qin, H., Yan, H., Xing, D., & Hu, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.033 · Cited by 124 · see citing works

Peptide-Functionalized Phase-Transformation Nanoparticles for Low Intensity Focused Ultrasound-Assisted Tumor Imaging and Therapy

Zhu, L., Zhao, H., Zhou, Z., Xia, Y., Wang, Z., Ran, H., Li, P., & Ren, J. (2018) · Nano Letters · doi:10.1021/acs.nanolett.7b05087 · Cited by 122 · see citing works

Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy

Li, Y., Li, Y., Ji, W., Lü, Z., Liu, L., Shi, Y., Ma, G., & Zhang, X. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b01641 · Cited by 121 · see citing works

siRNA Delivery with Stem Cell Membrane-Coated Magnetic Nanoparticles for Imaging-Guided Photothermal Therapy and Gene Therapy

Mu, X., Li, J., Yan, S., Zhang, H., Zhang, W., Zhang, F., & Jiang, J. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00858 · Cited by 120 · see citing works

Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer

Peng, J., Qi, T., Liao, J., Chu, B., Yang, Q., Qu, Y., Li, W., Li, H., Luo, F., & Qian, Z. (2014) · Theranostics · doi:10.7150/thno.7869 · Cited by 119 · see citing works

Programmed near-infrared light-responsive drug delivery system for combined magnetic tumor-targeting magnetic resonance imaging and chemo-phototherapy

Feng, Q., Zhang, Y., Zhang, W., Hao, Y., Wang, Y., Zhang, H., Hou, L., & Zhang, Z. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.035 · Cited by 112 · see citing works

Cascade-amplifying synergistic effects of chemo-photodynamic therapy using ROS-responsive polymeric nanocarriers

Sun, C., Cao, Z., Zhang, X., Sun, R., Yu, C., & Yang, X. (2018) · Theranostics · doi:10.7150/thno.24015 · Cited by 112 · see citing works

Programmed Nanoparticle‐Loaded Nanoparticles for Deep‐Penetrating 3D Cancer Therapy

Kim, J., Jo, C., Lim, W., Jung, S., Lee, Y. M., Lim, J., Lee, H., Lee, J., & Kim, W. J. (2018) · Advanced Materials · doi:10.1002/adma.201707557 · Cited by 111 · see citing works

Dynamic contrast-enhanced photoacoustic imaging using photothermal stimuli-responsive composite nanomodulators

Chen, Y., Yoon, S. J., Frey, W. U., Dockery, M. D., & Emelianov, S. (2017) · Nature Communications · doi:10.1038/ncomms15782 · Cited by 110 · see citing works

Multimodal selenium nanoshell-capped Au@mSiO2 nanoplatform for NIR-responsive chemo-photothermal therapy against metastatic breast cancer

Ramasamy, T., Ruttala, H. B., Sundaramoorthy, P., Poudel, B. K., Youn, Y. S., Ku, S., Choi, H., Yong, C. S., & Kim, J. O. (2018) · NPG Asia Materials · doi:10.1038/s41427-018-0034-5 · Cited by 109 · see citing works

Novel dual responsive alginate-based magnetic nanogels for onco-theranostics

Peng, N., Ding, X., Wang, Z., Cheng, Y., Gong, Z., Xu, X., Gao, X., Cai, Q., Huang, S., & Liu, Y. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.09.084 · Cited by 98 · see citing works

Triple Stimuli-Responsive Magnetic Hollow Porous Carbon-Based Nanodrug Delivery System for Magnetic Resonance Imaging-Guided Synergistic Photothermal/Chemotherapy of Cancer

Wu, F., Zhang, M., Lu, H., Liang, D., Huang, Y., Xia, Y., Hu, Y., Hu, S., Wang, J., Yi, X., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b07213 · Cited by 95 · see citing works

Hydroxyapatite/mesoporous silica coated gold nanorods with improved degradability as a multi-responsive drug delivery platform

Song, Z., Liu, Y., Shi, J., Ma, T., Zhang, Z., Ma, H., & Cao, S. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.11.012 · Cited by 94 · see citing works

Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy

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Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation

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Protein Delivery: Bioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery (Adv. Mater. 29/2018)

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Preparation, Characterization and In Vivo Antitumor Evaluation of a Micellar Formulation of Camptothecin Prodrug

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Iron Oxide Nanoparticle-Incorporated Polymeric Nanocomposites Composed of Poly(DL-lactide-co-glycolide)/Poly(ethylene gycol) Block Copolymer for Magnetic Responsive Drug Delivery Against Tumor

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Smart nanoparticles for cancer therapy

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pH-Responsive Polymer Nanomaterials for Tumor Therapy

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Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

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Review of a new bone tumor therapy strategy based on bifunctional biomaterials

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Nanotechnology: A Promising Approach for Cancer Diagnosis, Therapeutics and Theragnosis

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Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment

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Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges

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Shape Transformable Strategies for Drug Delivery

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Nanotechnology in medicine revolutionizing drug delivery for cancer and viral infection treatments

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Achieving Endo/Lysosomal Escape Using Smart Nanosystems for Efficient Cellular Delivery

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Recent advances in dual- and multi-responsive nanomedicines for precision cancer therapy

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Nanotechnology‐Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID‐19 Vaccines

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Nanobiotechnology-assisted therapies to manage brain cancer in personalized manner

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Cell Membrane Nanotherapeutics: From Synthesis to Applications Emerging Tools for Personalized Cancer Therapy

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Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?

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Regulation of cancer‐immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy

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Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer

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Research Progress of SN38 Drug Delivery System in Cancer Treatment

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Smart Nanosystems for Overcoming Multiple Biological Barriers in Cancer Nanomedicines Transport: Design Principles, Progress, and Challenges

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Albumin mediated reactive oxygen species scavenging and targeted delivery of methotrexate for rheumatoid arthritis therapy

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Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy

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Stimuli‐Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases

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Gadolinium-Doped Carbon Nanodots as Potential Anticancer Tools for Multimodal Image-Guided Photothermal Therapy and Tumor Monitoring

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Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma

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Pathogenesis and treatment of multiple myeloma

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Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy

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Therapeutic Strategies to Overcome Fibrotic Barriers to Nanomedicine in the Pancreatic Tumor Microenvironment

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Fluorescence for biological logic gates

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Magnetic mesoporous silica nanoparticles as advanced polymeric scaffolds for efficient cancer chemotherapy: recent progress and challenges

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Fabrication of Polymersomes: A Macromolecular Architecture in Nanotherapeutics

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Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

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Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

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Glutathione-triggered non-template synthesized porous carbon nanospheres serve as low toxicity targeted delivery system for cancer multi-therapy

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Recent progress in nanoformulations of cabazitaxel

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Proteolysis-targeting chimera (PROTAC) nanomedicines toward cancer treatment: From synthesis to therapeutic delivery

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Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy

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Serial stimuli-responsive theranostic nanomaterials for cancer therapy and imaging

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Organic nanomaterials for near-infrared light-triggered photothermal/thermodynamic combination therapy

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Syzygium cumini (L.) Extract-Derived Green Titanium Dioxide Nanoparticles Induce Caspase-Dependent Apoptosis in Hepatic Cancer Cells

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Raltitrexed-Modified Gold and Silver Nanoparticles for Targeted Cancer Therapy: Cytotoxicity Behavior In Vitro on A549 and HCT-116 Human Cancer Cells

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Advances in the applications of stimulus-responsive nanomedicines for anti-cancer therapy

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Nanodrugs systems for therapy and diagnosis of esophageal cancer

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Nanoparticle-Based Therapeutics to Overcome Obstacles in the Tumor Microenvironment of Hepatocellular Carcinoma

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Synthesis and biological evaluation of disulfides as anticancer agents with thioredoxin inhibition

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Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy

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SERS-guided photodynamic therapy: pioneering strategies in advanced cancer diagnosis and treatment

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Anti‐cancer potential of selenium‐chitosan‐polyethylene glycol‐carvacrol nanocomposites in multiple myeloma U266 cells

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Nanotherapeutics and Nanotheragnostics for Cancers: Properties, Pharmacokinetics, Biopharmaceutics, and Biosafety

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Influence of the Topology of Poly(L-Cysteine) on the Self-Assembly, Encapsulation and Release Profile of Doxorubicin on Dual-Responsive Hybrid Polypeptides

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Enhancing MRI through high loading of superparamagnetic nanogels with high sensitivity to the tumor environment

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Biomimetic synthesis of a novel O 2 -regeneration nanosystem for enhanced starvation/chemo-therapy

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Rational design of stimuli‐responsive magnetic polymer hybrid (nano)materials

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Nanoparticles for Anticancer Drug Delivery

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Optimization of Tyrosine Kinase Inhibitor-Loaded Gold Nanoparticles for Stimuli-Triggered Antileukemic Drug Release

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Limitations of Current Cancer Theranostics

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Synthesis, Renal Clearance, and Photothermal Therapy Based on the Self-Assembly of a Nanomedicine Consisting of Quaterrylene Bisimide and Glycocluster Conjugates

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Development and Characterization of a Novel Mixed Polymeric Micelle as a Potential Therapeutic Strategy for Osteosarcoma

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PLGA nanoparticle-based curcumin delivery as cancer therapeutics

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Nanomaterials in Brain Cancer Management with Special Emphasis on Personalized Therapy

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Cancer Diagnosis and Treatment with Nano-Approaches

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Enzyme-functionalized nanodrugs

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Smart nanoencapsulation for cancer therapy

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Nanomedicine in cancer care: Unmasking the hidden toxicological shadows

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Recent advances in nanomaterial delivery systems to administer metformin for cancer therapy

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Smart stimuli-responsive nanocarriers for the cancer therapy – nanomedicine

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Recent advances in dual- and multi-responsive nanomedicines for precision cancer therapy

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Stimuli-responsive nanocarriers for therapeutic applications in cancer

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Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

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STIMULUS-RESPONSIVE NANOCARRIERS FOR CANCER THERAPY

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