Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy
Abstract
Abstract Transition‐metal dyshomeostasis is recognized as a critical pathogenic factor at the onset and progression of neurodegenerative disorder (ND). Excess transition‐metal ions such as Cu2+ can catalyze the generation of cytotoxic reactive oxygen species and thereafter induce neuronal cell apoptosis. Exploring new chelating agents, which are not only capable of capturing excess redox‐active metal, but can also cross the blood–brain barrier (BBB), are highly desired for ND therapy. Herein, it is demonstrated that 2D black phosphorus (BP) nanosheets can capture Cu2+ efficiently and selectively to protect neuronal cells from Cu2+‐induced neurotoxicity. Moreover, both in vitro and in vivo studies show that the BBB permeability of BP nanosheets is significantly improved under near‐infrared laser irradiation due to their strong photothermal effect, which overcomes the drawback of conventional chelating agents. Furthermore, the excellent biocompatibility and stability guarantee the biosafety of BP in future clinical applications. Therefore, these features make BP nanosheets have the great potential to work as an efficient neuroprotective nanodrug for ND therapy.
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Under NIR, local hyperthermia for five minutes at 41-43°C increases generation of tiny mechanical waves, thus increasing BBB permeability.
“Under near-infrared irradiation, local hyperthermia for five minutes with the temperature at 41–43 °C increased the generation of tiny mechanical waves thus increasing the BBB permeability.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [214]
NIR irradiation for BBB permeability regulation under infrared thermal monitoring with head temperature <43°C causes negligible brain damage confirmed by histological staining.
“NIR irradiation for BBB permeability regulation was applied under infrared thermal monitoring and the head temperature was kept lower than 43 °C. At this power intensity, the irradiation caused negligible brain damage confirmed by histological staining.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [214]
Black phosphorus nanosheets under NIR keep power density over 37% of original and depth ~1.3-2.6 mm for mouse brain.
“the power density of light could be kept over 37% of the original value and the depth could be ~1.3–2.6 mm for the mouse brain.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [214]
Black phosphorus nanosheets show no obvious cerebral thrombosis on NMR imaging.
“they studied the risk of cerebral thrombosis using nuclear magnetic resonance imaging and found no obvious cerebral thrombosis”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [214]
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“213,214 The reduced transendothelial electrical resistance of cellular monolayer induced by irradiation could recover within 10 min.”
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“Very convincing evidence now supported the idea that functional nanomaterials show great potential as promising tools for AD treatment [35,42,43].”
Background
- Authors
- Chen, W., Ouyang, J., Yi, X., Xu, Y., Niu, C., Zhang, W., Wang, L., Sheng, J., Deng, L., Liu, Y., & Guo, S.
- Affiliations
- Central South University (CN)
- Peking University (CN)
- Corresponding author
- Deng, Liu
- Liu, You‐Nian
- Guo, Shaojun
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2017-11-30
- Volume
- 30
- Issue
- 3
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2775019552
- Cited by
- 374
- References
- 5
- Citations by year
- 2026: 17 · 2025: 37 · 2024: 43 · 2023: 33 · 2022: 52 · 2021: 60 · 2020: 63 · 2019: 47 · 2018: 21 · 2017: 1
- FWCI
- 16.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21636010, 21476266, 51671003)
- China Postdoctoral Science Foundation (185654)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
- Keywords
- black phosphorus nanosheets, neurodegenerative diseases, copper chelation, neuroprotection, blood-brain barrier permeability, photothermal effect, near-infrared laser irradiation, reactive oxygen species, neuronal apoptosis, nanotherapeutics, biocompatibility
- MeSH terms
- Humans, Hyperthermia, Induced, Phosphorus, Phototherapy, Neurodegenerative Diseases, Nanomedicine
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