The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade
Abstract
Although cancer immunotherapy based on immune checkpoint inhibitors holds great promise toward many types of cancers, several challenges still remain, associated with low objective response of patient rate as well as systemic side effects. Here, a combination immunotherapy strategy is developed based on a thermogelling reactive oxygen species (ROS)‐responsive polypeptide gel for sustained release of anti‐programmed cell death‐ligand 1 antibody and dextro‐1‐methyl tryptophan, inhibitor of indoleamine‐2,3‐dioxygenase with leveraging the ROS level in the tumor microenvironment. This bioresponsive gel depot can effectively reduce the local ROS level and facilitate release of immunotherapeutics, which leads to enhanced anti‐melanoma efficacy in vivo.
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Cites
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Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing
Kharaziha, M., Baidya, A., & Annabi, N. (2021) · Advanced Materials · doi:10.1002/adma.202100176 · Cited by 721
Zhou, F., Feng, B., Yu, H., Wang, D., Wang, T., Ma, Y., Wang, S., & Li, Y. (2019) · Advanced Materials · doi:10.1002/adma.201805888 · Cited by 507
Feng, B., Zhou, F., Hou, B., Wang, D., Wang, T., Fu, Y., Ma, Y., Yu, H., & Li, Y. (2018) · Advanced Materials · doi:10.1002/adma.201803001 · Cited by 451
Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Peng, S., Xiao, F., Chen, M., & Gao, H. (2022) · Advanced Science · doi:10.1002/advs.202103836 · Cited by 441
Multifaceted Design and Emerging Applications of Tissue Adhesives
Ma, Z., Bao, G., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202007663 · Cited by 269
Metadata
- Authors
- Yu, S., Wang, C., Yu, J., Wang, J., Lu, Y., Zhang, Y., Zhang, X., Hu, Q., Sun, W., He, C., Chen, X., & Gu, Z.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-05-22
- Volume
- 30
- Issue
- 28
- Pages
- e1801527-e1801527
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2804316397
- Cited by
- 294
- References
- 42
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, S., Wang, C., Yu, J., Wang, J., Lu, Y., Zhang, Y., Zhang, X., Hu, Q., Sun, W., He, C., Chen, X., & Gu, Z. (2018). Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade. Advanced Materials. https://doi.org/10.1002/adma.201801527
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
