Oxidative stress, inflammation, and cancer: How are they linked?
Open accessAbstract
Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases including cancer, diabetes, and cardiovascular, neurological, and pulmonary diseases. Oxidative stress can activate a variety of transcription factors including NF-κB, AP-1, p53, HIF-1α, PPAR-γ, β-catenin/Wnt, and Nrf2. Activation of these transcription factors can lead to the expression of over 500 different genes, including those for growth factors, inflammatory cytokines, chemokines, cell cycle regulatory molecules, and anti-inflammatory molecules. How oxidative stress activates inflammatory pathways leading to transformation of a normal cell to tumor cell, tumor cell survival, proliferation, chemoresistance, radioresistance, invasion, angiogenesis, and stem cell survival is the focus of this review. Overall, observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic oxidative stress and resultant oxidative damage have been implicated in many human diseases including cardiovascular disease, neurodegenerative diseases, diabetes, cancer, and aging.
“Chronic oxidative stress and the resultant oxidative damage have been implicated in many human diseases including cardiovascular disease, neurodegenerative diseases, diabetes, cancer, and the aging process [18,19,20,21,22].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746 · see citing works
Bonnet, D., & Dick, J. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,417 · see citing works
Identification of human brain tumour initiating cells
Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,388 · see citing works
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678 · see citing works
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115 · see citing works
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177 · see citing works
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works
ras oncogenes in human cancer: a review.
Bos, J. L. (1989) · PubMed · Cited by 5,061 · see citing works
Identification and expansion of human colon-cancer-initiating cells
Ricci‐Vitiani, L., Lombardi, D. G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., & Maria, R. D. (2006) · Nature · doi:10.1038/nature05384 · Cited by 4,001 · see citing works
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works
Targeting multidrug resistance in cancer
Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609 · see citing works
Hayes, J. D., Flanagan, J. U., & Jowsey, I. R. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095857 · Cited by 3,565 · see citing works
Tumorigenesis and the angiogenic switch
Bergers, G., & Benjamin, L. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1093 · Cited by 3,559 · see citing works
Identification of Pancreatic Cancer Stem Cells
Li, C., Heidt, D. G., Dalerba, P. D., Burant, C., Zhang, L., Adsay, V. N., Wicha, M. S., Clarke, M. F., & Simeone, D. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2030 · Cited by 3,344 · see citing works
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329 · see citing works
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961 · cited 2× · see citing works
“sentative redox-sensitive transcription factor [161], which is involved in cell transformation and proliferation [139,162].”
BackgroundProspective Identification of Tumorigenic Prostate Cancer Stem Cells
Collins, A. T., Berry, P. A., Hyde, C. F., Stower, M. J., & Maitland, N. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2018 · Cited by 2,821 · see citing works
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
Liotta, L. A., Steeg, P. S., & Stetler‐Stevenson, W. G. (1991) · Cell · doi:10.1016/0092-8674(91)90642-c · Cited by 2,701 · see citing works
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662 · cited 1× · see citing works
“tumors is associated with increased metastasis and poor survival of patients with several forms of squamous tumor [232,233].”
BackgroundAssociation of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works
Prooxidant States and Tumor Promotion
Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513 · see citing works
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,432 · see citing works
WISEMAN, H., & HALLIWELL, B. (1996) · Biochemical Journal · doi:10.1042/bj3130017 · Cited by 2,345 · see citing works
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212 · cited 1× · see citing works
“LPS activation induces the translocation of NF-κB, from the cytoplasm to the nucleus, where it interacts with κB elements in the NOS2 (iNOS) 5′ flanking region, triggering NOS2 transcription [86].”
BackgroundA cytokine-mediated link between innate immunity, inflammation, and cancer
Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31537 · Cited by 1,940 · see citing works
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works
Marnett, L. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.361 · Cited by 1,887 · see citing works
Role of oxygen radicals in DNA damage and cancer incidence
Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820 · see citing works
Ulcerative Colitis and Colorectal Cancer
Ekbom, A., Helmick, C. G., Zack, M. M., & Adami, H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231802 · Cited by 1,794 · see citing works
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769 · see citing works
Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R., Lankisch, P. G., Andersen, J. R., DiMagno, E. P., Andrén‐Sandberg, Å., & Domellöf, L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282001 · Cited by 1,753 · see citing works
Autophagy Suppresses Tumorigenesis through Elimination of p62
Mathew, R., Karp, C. M., Beaudoin, B., Vuong, N., Chen, G., Chen, H.-Y., Bray, K., Reddy, A., Bhanot, G. V., Gélinas, C., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.048 · Cited by 1,723 · see citing works
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690 · see citing works
Regulation of biosynthesis of nitric oxide.
Nathan, C., & Xie, Q. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36703-0 · Cited by 1,669 · see citing works
Alon, T., Hemo, I., Itin, A., Pe’er, J., Stone, J., & Keshet, E. (1995) · Nature Medicine · doi:10.1038/nm1095-1024 · Cited by 1,605 · see citing works
Matrix Metalloproteinases: Biologic Activity and Clinical Implications
Nelson, A. R., Fingleton, B., Rothenberg, M. L., & Matrisian, L. M. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.5.1135 · Cited by 1,555 · see citing works
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,540 · see citing works
Regulation of matrix metalloproteinase expression in tumor invasion
Westermarck, J. K., & Kähäri, V. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.8.781 · Cited by 1,494 · see citing works
Das, P. M., & Singal, R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.07.151 · Cited by 1,456 · see citing works
Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway
Gupta, S., Campbell, D., Dérijard, B., & Davis, R. J. (1995) · Science · doi:10.1126/science.7824938 · Cited by 1,440 · see citing works
Self-citationIdentification of cells initiating human melanomas
Schatton, T., Murphy, G. F., Frank, N. Y., Yamaura, K., Waaga-Gasser, A. M., Gasser, M., Zhan, Q., Jordan, S., Duncan, L. M., Weishaupt, C., et al. (2008) · Nature · doi:10.1038/nature06489 · Cited by 1,408 · see citing works
The changing faces of glutathione, a cellular protagonist
Alfonso Pompella, C., Visvikis, A., Paolicchi, A., Tata, V. D., & Casini, A. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00504-5 · Cited by 1,360 · see citing works
Oxidative stress: From basic research to clinical application
Sies, H. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90281-2 · Cited by 1,332 · see citing works
Oxidative stress and cancer: Have we moved forward?
Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302 · see citing works
Altered macrophage differentiation and immune dysfunction in tumor development
Sica, A., & Bronte, V. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31422 · Cited by 1,239 · see citing works
Rajagopalan, S., Meng, X. P., Ramasamy, S., Harrison, D. G., & Galis, Z. S. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119076 · Cited by 1,137 · see citing works
Inflammation and cancer: An ancient link with novel potentials
Hussain, S. P., & Harris, C. C. (2007) · International Journal of Cancer · doi:10.1002/ijc.23173 · Cited by 1,096 · see citing works
Folkman, J. (1985) · Advances in cancer research · doi:10.1016/s0065-230x(08)60946-x · Cited by 1,071 · see citing works
Free radicals, antioxidant enzymes, and carcinogenesis
Sun, Y. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90156-d · Cited by 1,067 · see citing works
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060 · see citing works
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00734-1 · Cited by 1,050 · see citing works
Ohshima, H., & Bartsch, H. (1994) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(94)90245-3 · Cited by 1,050 · see citing works
Glutathione in Cancer Biology and Therapy
Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041 · see citing works
Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034 · see citing works
Inflammation, a Key Event in Cancer Development
Lu, H., Ouyang, W., & Huang, C. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0261 · Cited by 1,031 · see citing works
Chronic inflammation and oxidative stress in human carcinogenesis
Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007) · International Journal of Cancer · doi:10.1002/ijc.23192 · Cited by 1,001 · see citing works
Apoptosis signaling by death receptors
Schulze‐Osthoff, K., Ferrari, D., Łoś, M., Wesselborg, S., & Peter, M. E. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2540439.x · Cited by 981 · see citing works
Reactive oxygen species in tumor progression
Peter, S. F. (2005) · Frontiers in bioscience · doi:10.2741/1667 · Cited by 957 · see citing works
The role of glutathione in cancer
Balendiran, G. K., Dabur, R., & Fraser, D. A. (2004) · Cell Biochemistry and Function · doi:10.1002/cbf.1149 · Cited by 929 · see citing works
Hiratsuka, S., Nakamura, K., Iwai, S., Murakami, M., Itoh, T., Kijima, H., Shipley, J. M., Senior, R. M., & Shibuya, M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00153-8 · Cited by 910 · see citing works
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, A., & Bar‐Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 854 · see citing works
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
Wang, X.-J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G. T., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn095 · Cited by 839 · see citing works
ROS and p53: A versatile partnership
Liu, B., Chen, Y., & Clair, D. K. S. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.011 · Cited by 829 · see citing works
Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine
Olivieri, G., Bodycote, J., & Wolff, S. M. (1984) · Science · doi:10.1126/science.6695170 · Cited by 826 · see citing works
Dual specificity phosphatases: a gene family for control of MAP kinase function
Camps, M., NICHOLS, A., & Arkinstall, S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.1.6 · Cited by 812 · see citing works
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
Keyse, S. M. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00075-7 · Cited by 808 · see citing works
Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways
McCubrey, J. A., LaHair, M. M., & Franklin, R. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1775 · Cited by 804 · see citing works
Inflammation: Gearing the journey to cancer
Kundu, J. K., & Surh, Y. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.03.002 · Cited by 804 · see citing works
Aggarwal, B. B., Vijayalekshmi, R. V., & Sung, B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0149 · Cited by 795 · see citing works
Self-citationMa, S., Lee, T. K., Zheng, B.-J., Chan, K. W., & Guan, X.-Y. (2007) · Oncogene · doi:10.1038/sj.onc.1210811 · Cited by 774 · see citing works
Role of reactive oxygen species in apoptosis: implications for cancer therapy
Matés, J. M., & Sánchez‐Jiménez, F. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00088-6 · Cited by 773 · see citing works
Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis
Weitzman, S., & Gordon, L. I. (1990) · Blood · doi:10.1182/blood.v76.4.655.655 · Cited by 761 · see citing works
Azad, M. B., Chen, Y., & Gibson, S. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2270 · Cited by 761 · see citing works
Szotek, P. P., Pieretti‐Vanmarcke, R., Masiakos, P. T., Dinulescu, D. M., Connolly, D. C., Foster, R., Dombkowski, D., Preffer, F. I., MacLaughlin, D. T., & Donahoe, P. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603672103 · Cited by 752 · see citing works
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.013 · Cited by 735 · see citing works
Thalmann, G. N., Anezinis, P., Chang, S., Zhau, H. E., Kim, E. E., Hopwood, V. L., Pathak, S., von Eschenbach, A. C., & Chung, L. W. K. (1994) · PubMed · Cited by 727 · see citing works
Some Current Insights into Oxidative Stress
Ďuračková, Z. (2010) · Physiological Research · doi:10.33549/physiolres.931844 · Cited by 718 · see citing works
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717 · see citing works
Increased risk of large-bowel cancer in Crohn's disease with colonic involvement
Ekbom, A., Adami, H., Helmick, C. G., & Zack, M. M. (1990) · The Lancet · doi:10.1016/0140-6736(90)91889-i · Cited by 698 · see citing works
Repopulation of cancer cells during therapy: an important cause of treatment failure
Kim, J. J., & Tannock, I. F. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1650 · Cited by 690 · see citing works
Base excision repair of oxidative DNA damage and association with cancer and aging
Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 685 · see citing works
Pham, C. G., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., Jayawardena, S., De Smaele, E., Cong, R., Beaumont, C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.017 · Cited by 663 · see citing works
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
Schetter, A. J., Heegaard, N. H. H., & Harris, C. C. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp272 · Cited by 659 · see citing works
LAU, A., VILLENEUVE, N., Sun, Z., Wong, P. K., & Zhang, D. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.09.003 · Cited by 645 · see citing works
The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
Jackson, A. L., & Loeb, L. A. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00091-4 · Cited by 630 · see citing works
Superoxide Dismutases in the Lung and Human Lung Diseases
Kinnula, V. L., & Crapo, J. D. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200212-1479so · Cited by 620 · see citing works
Oxidative stress, DNA methylation and carcinogenesis
Franco, R., Schoneveld, O., Georgakilas, A. G., & Panayiotidis, M. I. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.026 · Cited by 603 · see citing works
Activation of the JAK-STAT pathway by reactive oxygen species
Simon, A. R., Rai, U., Fanburg, B. L., & Cochran, B. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.6.c1640 · Cited by 600 · see citing works
Goossens, V., Grooten, J., Vos, K. J. D., & Fiers, W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8115 · Cited by 595 · see citing works
Reactive oxygen intermediates as mediators of programmed cell death in plants and animals
Jabs, T. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00227-5 · Cited by 591 · see citing works
Antioxidant activity, lipid peroxidation and skin diseases. What's new
Briganti, S., & Picardo, M. (2003) · Journal of the European Academy of Dermatology and Venereology · doi:10.1046/j.1468-3083.2003.00751.x · Cited by 590 · see citing works
Davis, K. L., Martin, E., Turko, I. V., & Murad, F. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.203 · Cited by 585 · see citing works
Redox signaling and the MAP kinase pathways
Torres, M., & Forman, H. J. (2003) · BioFactors · doi:10.1002/biof.5520170128 · Cited by 580 · see citing works
NF-κB as a therapeutic target in cancer
Orlowski, R. Z., & Baldwin, A. S. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02375-4 · Cited by 552 · see citing works
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
Meira, L. B., Bugni, J. M., Green, S. L., Lee, C., Pang, B., Borenshtein, D., Rickman, B. H., Rogers, A. B., Moroski-Erkul, C. A., McFaline‐Figueroa, J. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35073 · Cited by 548 · see citing works
Therapeutic strategies by modulating oxygen stress in cancer and inflammation
Fang, J. Q., Seki, T., & Maeda, H. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.02.005 · Cited by 545 · see citing works
Oxidative stress in prostate cancer
Khandrika, L., Kumar, B., Koul, S., MARONI, P. D., & Koul, H. K. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.12.011 · Cited by 528 · see citing works
Mitochondrial generation of free radicals and hypoxic signaling
Poyton, R. Ο., Ball, K. A., & Castello, P. R. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.04.001 · Cited by 525 · see citing works
Bartsch, H., & Nair, J. (2006) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-006-0073-1 · Cited by 517 · see citing works
The role of oxidative stress in chemical carcinogenesis.
Klaunig, J. E., Xu, Y., Isenberg, J. S., Bachowski, S., Kolaja, K. L., Jiang, J., Stevenson, D. E., & Walborg, E. F. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106s1289 · Cited by 515 · see citing works
Gillen, C. D., Walmsley, R. S., Prior, P., Andrews, H. A., & Allan, R. N. (1994) · Gut · doi:10.1136/gut.35.11.1590 · Cited by 515 · see citing works
Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound
Slaga, T. J., Klein–Szanto, A. J., Triplett, L. L., Yotti, L. P., & Trosko, J. E. (1981) · Science · doi:10.1126/science.6791284 · Cited by 502 · see citing works
Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases
Lo, Y. Y. C., Wong, J. M. S., & Cruz, T. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15703 · Cited by 497 · see citing works
TLR-4 Signaling Promotes Tumor Growth and Paclitaxel Chemoresistance in Ovarian Cancer
Kelly, M. G., Alvero, A. B., Chen, R., Silasi, D., Abrahams, V. M., Chan, S., Visintin, I., Rutherford, T., & Mor, G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3948 · Cited by 491 · see citing works
Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase
Ushio‐Fukai, M., & Alexander, R. W. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000044378.09409.b5 · Cited by 473 · see citing works
Oxidative mechanisms in carcinogenesis
Guyton, K. Z., & Kensler, T. W. (1993) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072628 · Cited by 467 · see citing works
Brown, N. S., & Bicknell, R. (2001) · Breast Cancer Research · doi:10.1186/bcr315 · Cited by 461 · see citing works
Inflammation and oncogenesis: a vicious connection
Grivennikov, S. I., & Karin, M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.11.004 · Cited by 460 · see citing works
Schmidt, K. N., Amstad, P., Cerutti, P., & Baeuerle, P. A. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90076-4 · Cited by 454 · see citing works
Mitochondrial redox control of matrix metalloproteinases
Nelson, K. K., & Melendez, J. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.008 · Cited by 443 · see citing works
Oxidative Stress in Pulmonary Fibrosis
Kinnula, V. L., Fattman, C. L., Tan, R. J., & Oury, T. D. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-017pp · Cited by 437 · see citing works
Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
Li, N., & Karin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13012 · Cited by 429 · see citing works
The role of free radicals in asbestos-induced diseases
Kamp, D. W., Graceffa, P., Pryor, W. A., & Weitzman, S. A. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90117-y · Cited by 428 · see citing works
Akt-dependent transformation: there is more to growth than just surviving
Plas, D. R., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1209097 · Cited by 427 · see citing works
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
Baba, T., Convery, P. A., Matsumura, N., Whitaker, R. S., Kondoh, E., Perry, T., Huang, Z., Bentley, R. C., Mori, S., Fujii, S., et al. (2008) · Oncogene · doi:10.1038/onc.2008.374 · Cited by 419 · see citing works
Inflammation and Cancer: How Friendly Is the Relationship For Cancer Patients?
Aggarwal, B., & Gehlot, P. (2009) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2009.06.020 · Cited by 412 · see citing works
Self-citationInflammation and Oxidative Stress in Carcinogenesis
Cerutti, P., & Amstad, P. (1993) · Springer eBooks · doi:10.1007/978-1-4615-3520-1_75 · Cited by 409 · see citing works
Inflammation and Lung Cancer: Roles of Reactive Oxygen/Nitrogen Species
Azad, N., Rojanasakul, Y., & Vallyathan, V. (2008) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701436460 · Cited by 409 · see citing works
Heme Oxygenase-1 in Tumors: Is It a False Friend?
Józkowicz, A., Waś, H., & Dulak, J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1659 · Cited by 381 · see citing works
Carcinogen-mediated oxidant formation and oxidative DNA damage
Frenkel, K. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90047-4 · Cited by 379 · see citing works
Funato, Y., Michiue, T., Asashima, M., & Miki, H. (2006) · Nature Cell Biology · doi:10.1038/ncb1405 · Cited by 378 · see citing works
An overview of the relationship between oxidative stress and chemical carcinogenesis
Trush, M. A., & Kensler, T. W. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90077-g · Cited by 374 · see citing works
Oxidant-induced DNA damage of target cells.
Schraufstätter, I. U., Hyslop, P. A., Jackson, J. H., & Cochrane, C. G. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113660 · Cited by 373 · see citing works
Halliwell, B. B. (1989) · PubMed · Cited by 368 · see citing works
Dypbukt, J. M., Ankarcrona, M., Burkitt, M. J., Sjöholm, Å., Ström, K., Orrenius, S., & Nicotera, P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43849-5 · Cited by 361 · see citing works
Surh, Y., Kundu, J. K., Na, H., & Lee, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2993s · Cited by 361 · see citing works
MOLECULAR INSIGHTS INTO PROSTATE CANCER PROGRESSION: THE MISSING LINK OF TUMOR MICROENVIRONMENT
Chung, L. W. K., Baseman, A. G., Assikis, V. J., & Zhau, H. E. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000141582.15218.10 · Cited by 358 · see citing works
Mantovani, A., Sica, A., Allavena, P., Garlanda, C., & Locati, M. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.02.008 · Cited by 350 · see citing works
Oxidants, antioxidants and carcinogenesis.
Ray, G., & Husain, S. A. (2002) · PubMed · Cited by 345 · see citing works
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity
Cao, J., Schulte, J., Knight, A., Leslie, N. R., Zagożdżon, A., Bronson, R. T., Manevich, Y., Beeson, C. C., & Neumann, C. A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.101 · Cited by 344 · see citing works
Karihtala, P., & Soini, Y. (2007) · Apmis · doi:10.1111/j.1600-0463.2007.apm_514.x · Cited by 342 · see citing works
Hypoxic cervical cancers with low apoptotic index are highly aggressive.
Höckel, M., Schlenger, K., Höckel, S., & Vaupel, P. W. (1999) · PubMed · Cited by 327 · see citing works
Roebuck, K. A. (1999) · International Journal of Molecular Medicine · doi:10.3892/ijmm.4.3.223 · Cited by 326 · see citing works
Inflammation by remote control
Mantovani, A. (2005) · Nature · doi:10.1038/435752a · Cited by 313 · see citing works
Touyz, R. M. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004000800018 · Cited by 312 · see citing works
Meir, E. G. V., Polverini, P. J., Chazin, V. R., Huang, H., de Tribolet, N., & Cavenee, W. K. (1994) · Nature Genetics · doi:10.1038/ng1094-171 · Cited by 307 · see citing works
Giri, D. K., & Aggarwal, B. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.14008 · Cited by 296 · see citing works
Self-citationReactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression
Kietzmann, T., & Görlach, A. (2005) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2005.03.010 · Cited by 295 · see citing works
Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells
Chen, R. J., Alvero, A. B., Silasi, D., Kelly, M. G., Fest, S., Visintin, I., Leiser, A., Schwartz, P. E., Rutherford, T., & Mor, G. (2008) · Oncogene · doi:10.1038/onc.2008.112 · Cited by 287 · see citing works
van Wetering, S., van Buul, J. D., Quik, S., Mul, E. P. J., Anthony, E. C., ten Klooster, J. P., Collard, J. G., & Hordijk, P. L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.9.1837 · Cited by 278 · see citing works
Reactive oxygen species-dependent signaling regulates cancer
Weinberg, F. D., & Chandel, N. S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0099-y · Cited by 276 · see citing works
Oxidative Stress and Signal Transduction
Schulze‐Osthoff, K., Bauer, M. K. A., Vogt, M., & Wesselborg, S. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5981-8 · Cited by 275 · see citing works
Activation of NF-κB by Antineoplastic Agents
Das, K. C., & White, C. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14914 · Cited by 273 · see citing works
Glutathione transferases and development of new principles to overcome drug resistance
SAU, A. C., Tregno, F. P., Valentino, F., Federici, G., & Caccuri, A. M. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.012 · Cited by 272 · see citing works
Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic
Lau, A. T. Y., Wang, Y., & Chiu, J. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21655 · Cited by 271 · see citing works
Oxidative stress in ulcerative colitis-associated carcinogenesis
Roessner, A., Kuester, D., Malfertheiner, P., & Schneider-Stock, R. (2008) · Pathology - Research and Practice · doi:10.1016/j.prp.2008.04.011 · Cited by 270 · see citing works
Konishi, H., Matsuzaki, H., Tanaka, M., Takemura, Y., Kuroda, S., Ono, Y., & Kikkawa, U. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00541-3 · Cited by 270 · see citing works
Manganese Superoxide Dismutase-Mediated Gene Expression in Radiation-Induced Adaptive Responses
Guo, G., Yan-Sanders, Y., Lyn‐Cook, B. D., Wang, T., Tamae, D., Ogi, J., Khaletskiy, A., Li, Z., Weydert, C. J. D., Longmate, J., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2362-2378.2003 · Cited by 270 · see citing works
Okada, F., Rak, J. W., Croix, B. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3609 · Cited by 269 · see citing works
Chronic inflammation, the tumor microenvironment and carcinogenesis
Gonda, T. A., Tu, S., & Wang, T. C. (2009) · Cell Cycle · doi:10.4161/cc.8.13.8985 · Cited by 269 · see citing works
Major alterations in the nucleotide structure of DNA in cancer of the female breast.
Malins, D. C., & Haimanot, R. (1991) · PubMed · Cited by 267 · see citing works
New insights on oxidative stress in cancer.
Visconti, R., & Grieco, D. (2009) · PubMed · Cited by 265 · see citing works
Kim, Y.-J., Ahn, J., Liang, P., Ip, C. C. Y., Zhang, Y., & Park, Y.-M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2401 · Cited by 256 · see citing works
Virgili, F., & Marino, M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.001 · Cited by 250 · see citing works
Cellular and molecular pathways linking inflammation and cancer
Porta, C., Larghi, P., Rimoldi, M., Totaro, M. G., Allavena, P., Mantovani, A., & Sica, A. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.06.014 · Cited by 250 · see citing works
Aruoma, O. I., & Halliwell, B. B. (1987) · Biochemical Journal · doi:10.1042/bj2410273 · Cited by 248 · see citing works
Schulte‐Hermann, R., Timmermann-Trosiener, I., Barthel, G., et al. (1990) · PubMed · Cited by 246 · see citing works
Heme Oxygenase-1: Redox Regulation of a Stress Protein in Lung and Cell Culture Models
Ryter, S. W., & Choi, A. M. K. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.80 · Cited by 244 · see citing works
Mazure, N. M., Chen, E. Y., Yeh, P., Laderoute, K. R., & Giaccia, A. J. (1996) · PubMed · Cited by 239 · see citing works
Activated neutrophils induce prolonged DNA damage in neighboring cells
Shacter, E. B., Beecham, E. J., Covey, J. M., et al. (1988) · Carcinogenesis · doi:10.1093/carcin/9.12.2297 · Cited by 238 · see citing works
The emerging role of reactive oxygen species in cancer therapy
Renschler, M. F. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.02.031 · Cited by 237 · see citing works
Persons, D. L., Yazlovitskaya, E. M., Cui, W., & Pelling, J. C. (1999) · PubMed · Cited by 237 · see citing works
The in vivo gene expression signature of oxidative stress
Han, E., Müller, F. L., Pérez, V., Qi, W., Liang, H., Liang, X., Fu, C., Doyle, E., Hickey, M., Cornell, J. E., et al. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.00239.2007 · Cited by 236 · see citing works
Lowenstein, C. J., & Padalko, E. Y. (2004) · Journal of Cell Science · doi:10.1242/jcs.01166 · Cited by 235 · see citing works
Matsui, A., Ikeda, T., Enomoto, K., Hosoda, K., Nakashima, H., Omae, K., Watanabe, M., Hibi, T., & Kitajima, M. (2000) · Cancer Letters · doi:10.1016/s0304-3835(99)00424-3 · Cited by 232 · see citing works
Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis
Musarrat, J., Arezina-Wilson, J., & Wani, A. A. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(96)00031-7 · Cited by 232 · see citing works
Fleisher, A. S., Esteller, M., Harpaz, N., Leytin, A., Rashid, A., Xu, Y., Liang, J., Stine, O. C., Yin, J., Zou, T., et al. (2000) · PubMed · Cited by 231 · see citing works
Reactive oxygen species and Alzheimer's disease
Multhaup, G., Ruppert, T., Schlicksupp, A., Hesse, L., Beher, D., Masters, C. L., & Beyreuther, K. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00062-2 · Cited by 226 · see citing works
Mechanism of c-fos induction by active oxygen.
Amstad, P., Krupitza, G., & Cerutti, P. (1992) · PubMed · Cited by 220 · see citing works
Mechanisms of ROS modulated cell survival during carcinogenesis
Clerkin, J. S., Naughton, R., Quiney, C., & Cotter, T. G. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.029 · Cited by 219 · see citing works
Garodia, P., Ichikawa, H., Malani, N., et al. (2007) · Journal of the Society for Integrative Oncology · doi:10.2310/7200.2006.029 · Cited by 216 · see citing works
Chan, D. W., Liu, V. W. S., Tsao, G. S., Yao, K., Furukawa, T., Chan, K. K. L., & Ngan, H. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn167 · Cited by 215 · see citing works
Zhang, Y., Qi, H., Taylor, R., Xu, W., Liu, L. F., & Jin, S. V. (2007) · Autophagy · doi:10.4161/auto.4127 · Cited by 211 · see citing works
Martey, C. A., Pollock, S. J., Turner, C. K., O’Reilly, K. M., Baglole, C. J., Phipps, R. P., & Sime, P. J. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00239.2003 · Cited by 207 · see citing works
Tishler, R. B., Calderwood, S. K., Coleman, C. N., & Price, B. D. (1993) · PubMed · Cited by 200 · see citing works
Invasive Potential Induced under Long-Term Oxidative Stress in Mammary Epithelial Cells
Mori, K., Shibanuma, M., & Nose, K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1725 · Cited by 197 · see citing works
Salivary analysis in oral cancer patients
Bahar, G., Feinmesser, R., Shpitzer, T., Popovtzer, A., & Nagler, R. M. (2006) · Cancer · doi:10.1002/cncr.22386 · Cited by 191 · see citing works
Roles of Nox1 and other Nox isoforms in cancer development
Kamata, T. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01207.x · Cited by 190 · see citing works
Bours, V., Dejardin, E., Letawe-Goujon, F., Merville, M., & Castronovo, V. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90448-0 · Cited by 185 · see citing works
Sandur, S. K., Deorukhkar, A., Pandey, M. K., Pabón, A. M., Shentu, S., Guha, S., Aggarwal, B. B., & Krishnan, S. (2009) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.06.034 · Cited by 183 · see citing works
Self-citationNitric Oxide and Reactive Oxygen Species in Parkinson's Disease
Tieu, K., Ischiropoulos, H., & Przedborski, S. (2003) · IUBMB Life · doi:10.1080/1521654032000114320 · Cited by 180 · see citing works
Hypoxic mammalian cell radiosensitization by nitric oxide.
Mitchell, J. B., Wink, D. A., DeGraff, W., et al. (1993) · PubMed · Cited by 175 · see citing works
Tabner, B. S. P. B. J., Turnbull, B. S. P. S., El-Agnaf, B. S. P. O. M. A., & Allsop, B. S. P. D. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394822 · Cited by 174 · see citing works
Miyajima, A., Nakashima, J., Yoshioka, K., Tachibana, M., Tazaki, H., & Murai, M. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.363 · Cited by 170 · see citing works
Regulation of drug transporters during infection and inflammation.
Petrović, V., Teng, S., & Piquette-Miller, M. (2007) · Molecular Interventions · doi:10.1124/mi.7.2.10 · Cited by 170 · see citing works
Cho, J., Manandhar, S., Lee, H., Park, H.-M., & Kwak, M. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.10.022 · Cited by 167 · see citing works
Yoon, S.-O., Park, S.-J., Yoon, S. Y., Yun, C.-H., & Chung, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202647200 · Cited by 165 · see citing works
Sung, S., Hsieh, C., Law, A., Zhau, H. E., Pathak, S., Multani, A. S., Lim, S., Coleman, I. M., Wu, L.-C., Figg, W. D., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2492 · Cited by 161 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039 · see citing works
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971 · see citing works
Nrf2 signaling pathway: pivotal roles in inflammation
Ahmed, S. M. U., Luo, L., Namani, A., Wang, X. J., & Tang, X. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.005 · Cited by 1,794 · see citing works
Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects
Zhang, H., & Tsao, R. (2016) · Current Opinion in Food Science · doi:10.1016/j.cofs.2016.02.002 · Cited by 1,519 · see citing works
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059 · see citing works
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Gao, M., Yu, F., Lv, C., Choo, J., & Chen, L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00908e · Cited by 827 · see citing works
Opportunities and challenges of radiotherapy for treating cancer
Schaue, D., & McBride, W. H. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.120 · Cited by 784 · see citing works
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Naik, E., & Dixit, V. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110367 · Cited by 783 · see citing works
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works
The Potential Benefits of Red Beetroot Supplementation in Health and Disease
Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015) · Nutrients · doi:10.3390/nu7042801 · Cited by 635 · see citing works
Dietary fiber and health outcomes: an umbrella review of systematic reviews and meta-analyses
Veronese, N., Solmi, M., Caruso, M. G., Giannelli, G., Osella, A. R., Evangelou, E., Maggi, S., Fontana, L., Stubbs, B., & Tzoulaki, I. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqx082 · Cited by 536 · see citing works
The role of zinc, copper, manganese and iron in neurodegenerative diseases
Mezzaroba, L., Alfieri, D. F., Colado Simão, A. N., & Vissoci Reiche, E. M. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.07.007 · Cited by 524 · see citing works
Obesity and Cancer Risk: Recent Review and Evidence
Basen-Engquist, K., & Chang, M. (2011) · Current Oncology Reports · doi:10.1007/s11912-010-0139-7 · Cited by 439 · see citing works
The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders
Vona, R., Pallotta, L., Cappelletti, M., Severi, C., & Matarrese, P. (2021) · Antioxidants · doi:10.3390/antiox10020201 · Cited by 431 · see citing works
The genomics of oxidative DNA damage, repair, and resulting mutagenesis
Poetsch, A. R. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.12.013 · Cited by 420 · see citing works
Campos-Rodriguez, F., Martinez-Garcia, M. A., Martinez, M., Duran-Cantolla, J., Peña, M. D. L., Masdeu, M. J., Gonzalez, M., Campo, F. D., Gallego, I., Marin, J. M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1671oc · Cited by 386 · see citing works
Roles of oxidative stress in polycystic ovary syndrome and cancers
Zuo, T., Zhu, M., & Xu, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8589318 · Cited by 319 · see citing works
Cell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases
Duvvuri, B., & Lood, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00502 · Cited by 282 · see citing works
Development of an antioxidant system after early weaning in piglets2
Yin, J., Wu, M. M., Xiao, H., Ren, W. K., Duan, J. L., Yang, G., Li, T. J., & Yin, Y. L. (2014) · Journal of Animal Science · doi:10.2527/jas.2013-6986 · Cited by 289 · see citing works
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis
Fouquerel, E., Barnes, R. P., Uttam, S., Watkins, S. C., Bruchez, M. P., & Opresko, P. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.024 · Cited by 275 · see citing works
Recent advances in microfluidic technologies for cell-to-cell interaction studies
Rothbauer, M., Zirath, H., & Ertl, P. (2018) · Lab on a Chip · doi:10.1039/c7lc00815e · Cited by 277 · see citing works
The Role of p53 in Metabolic Regulation
Puzio-Kuter, A. M. (2011) · Genes & Cancer · doi:10.1177/1947601911409738 · Cited by 273 · see citing works
T cells and reactive oxygen species
Belikov, A. V., Schraven, B., & Simeoni, L. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0194-3 · Cited by 264 · see citing works
Dysregulated relationship of inflammation and oxidative stress in major depression
Rawdin, B. J., Mellon, S. H., Dhabhar, F. S., Epel, E. S., Puterman, E., Su, Y., Burke, H. M., Reus, V. I., Rosser, R., Hamilton, S. P., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.11.011 · Cited by 255 · see citing works
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Morris, G., & Berk, M. (2015) · BMC Medicine · doi:10.1186/s12916-015-0310-y · Cited by 245 · see citing works
Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases
Bissinger, R., Bhuyan, A. A. M., Qadri, S. M., & Lang, F. (2019) · The FEBS Journal · doi:10.1111/febs.14606 · Cited by 239 · see citing works
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Cadet, J., Ravanat, J.-L., TavernaPorro, M., Menoni, H., & Angelov, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.005 · Cited by 233 · see citing works
Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases
Raposo, M., De Morais, A., & De Morais, R. (2015) · Marine Drugs · doi:10.3390/md13085128 · Cited by 228 · see citing works
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx073 · Cited by 226 · see citing works
Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling
Oh, Y., & Jun, H.-S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010026 · Cited by 217 · see citing works
Coradini, K., Lima, F. O., Oliveira, C. M., Chaves, P. S., Athayde, M. L., Carvalho, L. M., & Beck, R. C. R. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.04.009 · Cited by 200 · see citing works
Yang, Y., Zhao, X., Yu, J., Chen, X., Wang, R., Zhang, M., Zhang, Q., Zhang, Y., Wang, S., & Cheng, Y. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.04.007 · Cited by 180 · see citing works
Mazzone, P., Tierney, W., Hossain, M., Puvenna, V., Janigro, D., & Cucullo, L. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7124111 · Cited by 183 · see citing works
Metabolic shifts in residual breast cancer drive tumor recurrence
Havas, K. M., Milchevskaya, V., Radic, K., Alladin, A., Kafkia, E., Garcia, M., Stolte, J., Klaus, B., Rotmensz, N., Gibson, T. J., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89914 · Cited by 168 · see citing works
Subedi, L., Lee, T. H., Wahedi, H. M., Baek, S.-H., & Kim, S. Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8379539 · Cited by 174 · see citing works
Zhu, J., Wang, H., Chen, F., Fu, J., Xu, Y., Hou, Y., Kou, H. H., Zhai, C., Nelson, M. B., Zhang, Q., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.010 · Cited by 162 · see citing works
Obstructive sleep apnea is associated with cancer mortality in younger patients
Martínez-García, M. A., Campos-Rodriguez, F., Durán-Cantolla, J., de la Peña, M., Masdeu, M. J., González, M., del Campo, F., Serra, P. C., Valero-Sánchez, I., Ferrer, M. J. S., et al. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.01.020 · Cited by 155 · see citing works
Neumann, U., Derwenskus, F., Flaiz Flister, V., Schmid-Staiger, U., Hirth, T., & Bischoff, S. (2019) · Antioxidants · doi:10.3390/antiox8060183 · Cited by 154 · see citing works
ROS sets the stage for macrophage differentiation
Covarrubias, A., Byles, V., & Horng, T. (2013) · Cell Research · doi:10.1038/cr.2013.88 · Cited by 150 · see citing works
Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease
Dubey, T., & Chinnathambi, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108153 · Cited by 151 · see citing works
Measurement of oxidatively generated base damage in cellular DNA
Cadet, J., Douki, T., & Ravanat, J.-L. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.02.004 · Cited by 136 · see citing works
Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge
Carr, A. C., & Cook, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01182 · Cited by 133 · see citing works
Grishanova, A. Y., & Perepechaeva, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126719 · Cited by 130 · see citing works
Grape seed oil: A potential functional food?
SHINAGAWA, F. B., SANTANA, F. C. D., TORRES, L. R. O., & MANCINI-FILHO, J. (2015) · Food Science and Technology · doi:10.1590/1678-457x.6826 · Cited by 125 · see citing works
Okuno, Y., Fukuhara, A., Hashimoto, E., Kobayashi, H., Kobayashi, S., Otsuki, M., & Shimomura, I. (2018) · Diabetes · doi:10.2337/db17-1032 · Cited by 124 · see citing works
Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway
Tossetta, G., & Marzioni, D. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106365 · Cited by 115 · see citing works
Ye, G., Xie, Z., Zeng, H., Wang, P., Li, J., Zheng, G., Wang, S., Cao, Q., Li, M., Liu, W., et al. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-02993-x · Cited by 115 · see citing works
Sleep apnea and subsequent cancer incidence
Sillah, A., Watson, N. F., Schwartz, S. M., Gozal, D., & Phipps, A. I. (2018) · Cancer Causes & Control · doi:10.1007/s10552-018-1073-5 · Cited by 113 · see citing works
Jenkins, D. J. A., Willett, W. C., Yusuf, S., Hu, F. B., Glenn, A. J., Liu, S., Mente, A., Miller, V., Bangdiwala, S. I., Gerstein, H. C., et al. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00344-3 · Cited by 117 · see citing works
Verrastro, I., Pasha, S., Jensen, K., Pitt, A., & Spickett, C. (2015) · Biomolecules · doi:10.3390/biom5020378 · Cited by 114 · see citing works
The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice
Pasinetti, G. M., Singh, R., Westfall, S., Herman, F., Faith, J., & Ho, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171151 · Cited by 112 · see citing works
Red Beetroot and Betalains as Cancer Chemopreventative Agents
Lechner, J. F., & Stoner, G. D. (2019) · Molecules · doi:10.3390/molecules24081602 · Cited by 122 · see citing works
The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life
Carr, A. C., Vissers, M. C. M., & Cook, J. S. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00283 · Cited by 104 · see citing works
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Setayesh, T., Nersesyan, A., Mišík, M., Ferk, F., Langie, S., Andrade, V. M., Haslberger, A., & Knasmüller, S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.07.001 · Cited by 98 · see citing works
Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects
Yang, S., Han, G., Chen, Q., Yu, L., Wang, P., Zhang, Q., Dong, J., Zhang, W., & Huang, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s287523 · Cited by 81 · see citing works
Zhuang, C., Wu, Z., Xing, C., & Miao, Z. (2017) · MedChemComm · doi:10.1039/c6md00500d · Cited by 84 · see citing works
Dionisie, V., Ciobanu, A. M., Toma, V. A., Manea, M. C., Baldea, I., Olteanu, D., Sevastre-Berghian, A., Clichici, S., Manea, M., Riga, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147483 · Cited by 78 · see citing works
Najar, B., Shortrede, J. E., Pistelli, L., & Buhagiar, J. (2020) · Chemistry & Biodiversity · doi:10.1002/cbdv.201900478 · Cited by 76 · see citing works
Malaria inflammation by xanthine oxidase-produced reactive oxygen species
Ty, M. C., Zuniga, M., Götz, A., Kayal, S., Sahu, P. K., Mohanty, A., Mohanty, S., Wassmer, S. C., & Rodriguez, A. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809903 · Cited by 73 · see citing works
Melanocytes in the Skin – Comparative Whole Transcriptome Analysis of Main Skin Cell Types
Reemann, P., Reimann, E., Ilmjärv, S., Porosaar, O., Silm, H., Jaks, V., Vasar, E., Kingo, K., & Kõks, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115717 · Cited by 64 · see citing works
Moons, W. G., & Shields, G. S. (2015) · Emotion · doi:10.1037/emo0000055 · Cited by 64 · see citing works
A microfluidic co-culture system to monitor tumor-stromal interactions on a chip
Menon, N. V., Chuah, Y. J., Cao, B., Lim, M., & Kang, Y. (2014) · Biomicrofluidics · doi:10.1063/1.4903762 · Cited by 53 · see citing works
Diehl, K., Dinges, L.-A., Helm, O., Ammar, N., Plundrich, D., Arlt, A., Röcken, C., Sebens, S., & Schäfer, H. (2018) · Oncogene · doi:10.1038/onc.2017.299 · Cited by 58 · see citing works
Ariyoshi, T., Hagihara, M., Eguchi, S., Fukuda, A., Iwasaki, K., Oka, K., Takahashi, M., Yamagishi, Y., & Mikamo, H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.587725 · Cited by 45 · see citing works
Chen, C.-Y., Hu, J.-M., Shen, C.-J., Chou, Y.-C., Tian, Y.-F., Chen, Y.-C., You, S.-L., Hung, C.-F., Lin, T.-C., Hsiao, C.-W., et al. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2019.02.016 · Cited by 45 · see citing works
Measurement of oxidatively generated base damage to nucleic acids in cells: facts and artifacts
Cadet, J., Douki, T., Ravanat, J.-L., & Wagner, J. R. (2012) · Bioanalytical Reviews · doi:10.1007/s12566-012-0029-6 · Cited by 38 · see citing works
Deminice, R., Cella, P. S., Padilha, C. S., Borges, F. H., da Silva, L. E. C. M., Campos-Ferraz, P. L., Jordao, A. A., Robinson, J. L., Bertolo, R. F., Cecchini, R., et al. (2016) · Amino Acids · doi:10.1007/s00726-016-2172-9 · Cited by 37 · see citing works
Puig, Á., Rancan, L., Paredes, S. D., Carrasco, A., Escames, G., Vara, E., & Tresguerres, J. A. F. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2015.11.021 · Cited by 37 · see citing works
Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology
Data-Franco, J., Singh, A., Popovic, D., Ashton, M., Berk, M., Vieta, E., Figueira, M. L., & Dean, O. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.004 · Cited by 38 · see citing works
Oral supplementation with cocoa extract reduces UVB-Induced wrinkles in hairless mouse skin
Kim, J.-E., Song, D., Kim, J., Choi, J., Kim, J. R., Yoon, H.-S., Bae, J.-S., Han, M., Lee, S., Hong, J. S., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.11.032 · Cited by 37 · see citing works
Kim, J. N., Han, S. N., Ha, T. J., & Kim, H.-K. (2017) · Nutrition Research and Practice · doi:10.4162/nrp.2017.11.5.357 · Cited by 30 · see citing works
do Prado, C. H., Grassi-Oliveira, R., Wieck, A., Zaparte, A., Filho, L. D., da Silva Morrone, M., Moreira, J. C., & Bauer, M. E. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.01.062 · Cited by 28 · see citing works
Phlebotomy as a preventive measure for crocidolite-induced mesothelioma in male rats
Ohara, Y., Chew, S., Shibata, T., Okazaki, Y., Yamashita, K., & Toyokuni, S. (2018) · Cancer Science · doi:10.1111/cas.13460 · Cited by 28 · see citing works
Guesmi, F., Bellamine, H., & Landoulsi, A. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0107 · Cited by 27 · see citing works
The interplay between vitamin C and thyroid
Farasati Far, B., Behnoush, A. H., Ghondaghsaz, E., Habibi, M. A., & Khalaji, A. (2023) · Endocrinology, Diabetes & Metabolism · doi:10.1002/edm2.432 · Cited by 23 · see citing works
Chaisiriwong, L., Wanitphakdeedecha, R., Sitthinamsuwan, P., Sampattavanich, S., Chatsiricharoenkul, S., Manuskiatti, W., & Panich, U. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5934024 · Cited by 20 · see citing works
Nitroxide delivery system for Nrf2 activation and skin protection
Ben Yehuda Greenwald, M., Frušić-Zlotkin, M., Soroka, Y., Sasson, S. B., Bianco-Peled, H., Bitton, R., & Kohen, R. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.05.008 · Cited by 18 · see citing works
Contribution of behavioral health factors to non-AIDS-related comorbidities: an updated review
Chichetto, N. E., Polanka, B. M., So-Armah, K. A., Sung, M., Stewart, J. C., Koethe, J. R., Edelman, E. J., Tindle, H. A., & Freiberg, M. S. (2020) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00498-y · Cited by 17 · see citing works
Chen, X., Wu, F., Chen, C., Ren, Q., & Zhang, A. (2024) · Biological Trace Element Research · doi:10.1007/s12011-023-04021-3 · Cited by 11 · see citing works
Telomeric 8-Oxoguanine Drives Rapid Premature Senescence In The Absence Of Telomere Shortening
Barnes, R. P., de Rosa, M., Thosar, S. A., Detwiler, A. C., Roginskaya, V., Van Houten, B., Bruchez, M. P., Stewart-Ornstein, J., & Opresko, P. L. (2021) · doi:10.1101/2021.05.05.442662
Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-<i>β</i>Signaling
Noh, S., Ahn, K.-S., Oh, S.-R., Kim, K. H., & Joo, M. (2015) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2015/897272 · Cited by 10 · see citing works
Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
Welcome, M. O., & Mastorakis, N. E. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104769 · Cited by 139 · see citing works
- Authors
- Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Aggarwal, Bharat B.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 49
- Issue
- 11
- Pages
- 1603-1616
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC2990475
- OpenAlex
- W2094156327
- Cited by
- 5,441
- References
- 316
- Citations by year
- 2026: 362 · 2025: 413 · 2024: 418 · 2023: 429 · 2022: 516 · 2021: 507 · 2020: 421 · 2019: 407 · 2018: 391 · 2017: 371 · 2016: 316 · 2015: 238 · 2014: 240 · 2013: 177 · 2012: 131
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Fonds National de la Recherche Luxembourg (PDR-08-017)
- National Institutes of Health (CA-16672, CA-124787-01A2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- oxidative stress, chronic inflammation, cancer, transcription factors, NF-κB, AP-1, p53, HIF-1α, PPARγ, Nrf2, inflammatory cytokines, chemokines, chemoresistance, radioresistance (biology), tumor invasion, angiogenesis, cancer stem cells, tumor cell survival
- MeSH terms
- Animals, Cell Survival, Cell Transformation, Neoplastic, Humans, Inflammation, Models, Biological, Neoplasms, Neovascularization, Pathologic, Signal Transduction, Oxidative Stress, Drug Resistance, Neoplasm, Tumor Escape, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
