The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Through Scalp and Skull NIR‐II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance
Abstract
Brain tumor is one of the most lethal cancers owing to the existence of blood–brain barrier and blood–brain tumor barrier as well as the lack of highly effective brain tumor treatment paradigms. Herein, cyclo(Arg‐Gly‐Asp‐D‐Phe‐Lys(mpa)) decorated biocompatible and photostable conjugated polymer nanoparticles with strong absorption in the second near‐infrared (NIR‐II) window are developed for precise photoacoustic imaging and spatiotemporal photothermal therapy of brain tumor through scalp and skull. Evidenced by the higher efficiency to penetrate scalp and skull for 1064 nm laser as compared to common 808 nm laser, NIR‐II brain‐tumor photothermal therapy is highly effective. In addition, via a real‐time photoacoustic imaging system, the nanoparticles assist clear pinpointing of glioma at a depth of almost 3 mm through scalp and skull with an ultrahigh signal‐to‐background ratio of 90. After spatiotemporal photothermal treatment, the tumor progression is effectively inhibited and the survival spans of mice are significantly extended. This study demonstrates that NIR‐II conjugated polymer nanoparticles are promising for precise imaging and treatment of brain tumors.
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Cited by
Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,155
Second near-infrared photothermal materials for combinational nanotheranostics
Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941
Photoacoustic clinical imaging
Steinberg, I., Huland, D. M., Vermesh, O., Frostig, H. E., Tummers, W. S., & Gambhir, S. S. (2019) · Photoacoustics · doi:10.1016/j.pacs.2019.05.001 · Cited by 553
Ultrasound‐Activated Sensitizers and Applications
Lin, X., Song, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201906823 · Cited by 501
Recent advances in nanomaterials for enhanced photothermal therapy of tumors
Hu, J.-J., Cheng, Y.-J., & Zhang, X.-Z. (2018) · Nanoscale · doi:10.1039/c8nr07627h · Cited by 409
Metadata
- Authors
- Guo, B., Sheng, Z., Hu, D., Liu, C., Zheng, H., & Liu, B.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2018-07-10
- Volume
- 30
- Issue
- 35
- Pages
- e1802591-e1802591
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2888345701
- Cited by
- 431
- References
- 52
- FWCI
- 19.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guo, B., Sheng, Z., Hu, D., Liu, C., Zheng, H., & Liu, B. (2018). Through Scalp and Skull NIR‐II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance. Advanced Materials. https://doi.org/10.1002/adma.201802591
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