A small-molecule dye for NIR-II imaging
Abstract
Fluorescent imaging of biological systems in the second near-infrared window (NIR-II) can probe tissue at centimetre depths and achieve micrometre-scale resolution at depths of millimetres. Unfortunately, all current NIR-II fluorophores are excreted slowly and are largely retained within the reticuloendothelial system, making clinical translation nearly impossible. Here, we report a rapidly excreted NIR-II fluorophore (∼90% excreted through the kidneys within 24 h) based on a synthetic 970-Da organic molecule (CH1055). The fluorophore outperformed indocyanine green (ICG)-a clinically approved NIR-I dye-in resolving mouse lymphatic vasculature and sentinel lymphatic mapping near a tumour. High levels of uptake of PEGylated-CH1055 dye were observed in brain tumours in mice, suggesting that the dye was detected at a depth of ∼4 mm. The CH1055 dye also allowed targeted molecular imaging of tumours in vivo when conjugated with anti-EGFR Affibody. Moreover, a superior tumour-to-background signal ratio allowed precise image-guided tumour-removal surgery.
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On the basis of a consecutive incorporation of common rotors (triphenylamine (TPA), TPE) as electron-donating groups that are directly conjugated to the acceptor unit or introduced to the donor groups, a number of new D-A-D dyes have been developed.
“On the basis of a consecutive incorporation of common rotors (triphenylamine (TPA), TPE) as electron-donating groups that are directly conjugated to the acceptor unit or introduced to the donor groups, a number of new D-A-D dyes have been developed.52,61,145−148”
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- Authors
- Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., Zhang, X., Yaghi, O. K., Alamparambil, Z. R., Hong, X., Cheng, Z., & Dai, H.
- Affiliations
- Wuhan University (CN)
- Stanford Medicine (US)
- Stanford University (US)
- Corresponding author
- Hong, Xuechuan
- Cheng, Zhen
- Dai, Hongjie
- ORCID
- Venue
- Nature Materials
- Published
- 2015-11-23
- Volume
- 15
- Issue
- 2
- Pages
- 235-242
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2261575366
- Cited by
- 1,778
- References
- 1
- Citations by year
- 2026: 135 · 2025: 170 · 2024: 194 · 2023: 189 · 2022: 197 · 2021: 220 · 2020: 223 · 2019: 183 · 2018: 156 · 2017: 80 · 2016: 29
- FWCI
- 71.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (U54CA119367)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- NIR-II fluorescence imaging, small-molecule dyes, renal excretion, lymphatic imaging, sentinel lymph node mapping, brain tumor imaging, tumor-to-background ratio, affibody, reticuloendothelial system clearance
- MeSH terms
- Animals, Benzopyrans, Carcinoma, Squamous Cell, Diagnostic Imaging, Female, Fluorescent Dyes, Humans, Indoles, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Neoplasms, Experimental, Phenylpropionates, Thiadiazoles, Spectroscopy, Near-Infrared, Cell Line, Tumor, Mice
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