Cited by 220Hydrogels: synthesis, properties, applicationsCancer Immunotherapy and BiomarkersNanoplatforms for cancer theranostics

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

Ruan, Huitong, Hu, Quanyin, Wen, Di, Chen, Qian, Chen, Guojun, Lu, Yifei, Wang, Jinqiang, Cheng, Hao, Lu, Weiyue, Gu, Zhen·2019·Advanced Materials

DOI 10.1002/adma.201806957

Open this paper in CoChat — free account

Abstract

Patients with advanced melanoma that is of low tumor‐associated antigen (TAA) expression often respond poorly to PD‐1/PD‐L1 blockade therapy. Epigenetic modulators, such as hypomethylation agents (HMAs), can enhance the antitumor immune response by inducing TAA expression. Here, a dual bioresponsive gel depot that can respond to the acidic pH and reactive oxygen species (ROS) within the tumor microenvironment (TME) for codelivery of anti‐PD1 antibody (aPD1) and Zebularine (Zeb), an HMA, is engineered. aPD1 is first loaded into pH‐sensitive calcium carbonate nanoparticles (CaCO 3 NPs), which are then encapsulated in the ROS‐responsive hydrogel together with Zeb (Zeb‐aPD1‐NPs‐Gel). It is demonstrated that this combination therapy increases the immunogenicity of cancer cells, and also plays roles in reversing immunosuppressive TME, which contributes to inhibiting the tumor growth and prolonging the survival time of B16F10‐melanoma‐bearing mice.

Integrity signals

Registry

Crossref · 10.1002/adma.201806957

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
Garon, E. B., Rizvi, N. A., Hui, R., Leighl, N., Balmanoukian, A. S., Eder, J. P., Patnaik, A., Aggarwal, C., Gubens, M., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1501824 · Cited by 6,198
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
Motzer, R. J., Escudier, B., McDermott, D. F., George, S., Hammers, H. J., Srinivas, S., Tykodi, S. S., Sosman, J. A., Procopio, G., Plimack, E. R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1510665 · Cited by 5,807
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma, P., Hu-Lieskovan, S., Wargo, J. A., & Ribas, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.017 · Cited by 5,588
The future of immune checkpoint therapy
Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878
Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial
El-Khoueiry, A. B., Sangro, B., Yau, T., Crocenzi, T. S., Kudo, M., Hsu, C., Kim, T.-Y., Choo, S.-P., Trojan, J., Welling, T. H., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31046-2 · Cited by 4,280
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
Topalian, S. L., Sznol, M., McDermott, D. F., Kluger, H. M., Carvajal, R. D., Sharfman, W. H., Brahmer, J. R., Lawrence, D. P., Atkins, M. B., Powderly, J. D., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.53.0105 · Cited by 2,222
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin, M. M., Zhang, X., Schuster, H., Caron, E., Ward, J. P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C. D., Krebber, W.-J., et al. (2014) · Nature · doi:10.1038/nature13988 · Cited by 1,974
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy
Chen, Q., Xu, L., Liang, C., Wang, C., Peng, R., & Liu, Z. (2016) · Nature Communications · doi:10.1038/ncomms13193 · Cited by 1,612
Self-citation
Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future
Chen, L., & Han, X. N. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80011 · Cited by 1,455
A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization
Sanmamed, M. F., & Chen, L. (2018) · Cell · doi:10.1016/j.cell.2018.09.035 · Cited by 1,414

Flagged first, then by citations

Show all 55 references

Research works printed but not linked: 4

Héninger E., 2015, Front. Immunol., 6, 29
Gnyszka A., 2013, Anticancer Res., 33, 2989
Sasaki M., 2001, Cancer Res., 61, 4809
Nishiyama N., 2003, Cancer Res., 63, 8977

Sorted by citations

Items 101–200 of 218

Immune Cycle‐Based Strategies for Cancer Immunotherapy
Li, Y., Liu, X., Zhang, X., Pan, W., Li, N., & Tang, B. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107540 · Cited by 42
Biological signal integrated microfluidic hydrogel microspheres for promoting bone regeneration
Zhao, Z., Li, R., Ruan, H., Cai, Z., Zhuang, Y., Han, Z., Zhang, M., Cui, W., & Cai, M. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135176 · Cited by 43
Self-citation
Wrecking neutrophil extracellular traps and antagonizing cancer-associated neurotransmitters by interpenetrating network hydrogels prevent postsurgical cancer relapse and metastases
Zhou, H., Zhu, C., Zhao, Q. C., Ni, J., Zhang, H., Yang, G., Ge, J., Fang, C., Wei, H., Zhou, X., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.022 · Cited by 42
Independent Tuning of Nano‐Ligand Frequency and Sequences Regulates the Adhesion and Differentiation of Stem Cells
Min, S., Jeon, Y. S., Jung, H. J., Khatua, C., Li, N., Bae, G., Choi, H., Hong, H., Shin, J. E., Ko, M. J., et al. (2020) · Advanced Materials · doi:10.1002/adma.202004300 · Cited by 41
Tumor microenvironment-responsive manganese-based nano-modulator activate the cGAS-STING pathway to enhance innate immune system response
Liang, X., Wang, D., Zhao, Y., Wang, X., Yao, S., Huang, W., Yang, Y., Dong, X., Zhang, L., & Yang, J. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02809-6 · Cited by 40
Immunogenic Cell Death and Metabolic Reprogramming in Cancer: Mechanisms, Synergies, and Innovative Therapeutic Strategies
Jiang, J., Yan, Y., Yang, C., & Cai, H. (2025) · Biomedicines · doi:10.3390/biomedicines13040950 · Cited by 43
Remote Manipulation of Slidable Nano‐Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages
Choi, H., Bae, G., Khatua, C., Min, S., Jung, H. J., Li, N., Jun, I., Liu, H., Cho, Y., Na, K., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202001446 · Cited by 38
Trauma-Responsive Scaffold Synchronizing Oncolysis Immunization and Inflammation Alleviation for Post-Operative Suppression of Cancer Metastasis
Li, J., Zhang, P., Zhou, M., Liu, C., Huang, Y., & Li, L. (2022) · ACS Nano · doi:10.1021/acsnano.1c11562 · Cited by 37
ROS-responsive microneedles loaded with integrin avβ6-blocking antibodies for the treatment of pulmonary fibrosis
Ding, H., Cui, Y., Yang, J., Li, Y., Zhang, H., Ju, S., Ren, X., Ding, C., & Zhao, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.060 · Cited by 37
Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation
Zuo, L., Ding, J., Li, C., Lin, F., Chen, P. R., Wang, P., Lu, G., Zhang, J., Huang, L., & Xie, H. (2020) · Chemical Science · doi:10.1039/c9sc05036a · Cited by 37
Microsphere‐containing Hydrogel Scaffolds for Tissue Engineering
Zhang, S., Lin, A., Tao, Z., Fu, Y., Xiao, L., Ruan, G., & Li, Y. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200630 · Cited by 36
Advances in PD-1 signaling inhibition-based nano-delivery systems for tumor therapy
Liu, S., Wang, H., Shao, X., Chen, H., Chao, S., Zhang, Y., Gao, Z., Yao, Q., & Zhang, P. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01966-4 · Cited by 36
Stable and Biocompatible Cellulose-Based CaCO3 Microspheres for Tunable pH-Responsive Drug Delivery
Yan, G., Feng, Y., Gao, Z., Zeng, X., Hong, W., Liu, W., Sun, Y. Q., Tang, X., Lei, T., & Lin, L. (2019) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b05144 · Cited by 36
Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy
Wang, M., Zhou, B., Wang, L., Zhou, F., Smith, N., Saunders, D., Towner, R. A., Song, J., Qu, J., & Chen, W. R. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01453b · Cited by 36
Doxorubicin/CpG self-assembled nanoparticles prodrug and dendritic cells co-laden hydrogel for cancer chemo-assisted immunotherapy
Yang, A., Dong, X., Bai, Y., Sheng, S., Zhang, Y., Liu, T., Zhu, D., & Lv, F. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129192 · Cited by 36
Nrf2 silencing amplifies DNA photooxidative damage to activate the STING pathway for synergistic tumor immunotherapy
Sun, S., Yu, M., Liu, Y., Huang, W., Zhu, M., Fu, Y., Yan, L., Wang, Q., Ji, X., Zhao, J., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122068 · Cited by 35
Bioresorbable Scaffolds with Biocatalytic Chemotherapy and In Situ Microenvironment Modulation for Postoperative Tissue Repair
Xue, C., Li, M., Sutrisno, L., Yan, B., Zhao, Y., Hu, Y., Cai, K., Zhao, Y., Yu, S., & Luo, Z. Y. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008732 · Cited by 35
Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy
Chen, M., Juengpanich, S., Li, S., Topatana, W., Lu, Z., Zheng, Q., Cao, J., Hu, J., Chan, E., Hou, L., et al. (2022) · Advanced Science · doi:10.1002/advs.202103895 · Cited by 35
Self-citation
Targeting the Epigenome in Malignant Melanoma: Facts, Challenges and Therapeutic Promises
Anestopoulos, I., Kyriakou, S., Tragkola, V., Paraskevaidis, I., Tzika, E., Mitsiogianni, M., Deligiorgi, M. V., Petrakis, G., Trafalis, D. T., Botaitis, S., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108301 · Cited by 36
Hyaluronic acid methacryloyl/chitosan methacryloyl/3-methacrylamidophenylboronic acid multifunctional hydrogel loading exosome for diabetic wound healing
Yuan, W., Huang, C., Deng, W., Lai, J., Chen, J., Jie, J., Wu, Y., You, T., & Wu, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135562 · Cited by 34
A generally minimalist strategy of constructing biomineralized high-efficiency personalized nanovaccine combined with immune checkpoint blockade for cancer immunotherapy
Zhang, S., Feng, Y., Meng, M., Li, Z., Li, H., Lin, L., Xu, C., Chen, J., Hao, K., Tang, Z., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121794 · Cited by 34
Application of injectable hydrogels in cancer immunotherapy
Liu, C., Liao, Y., Liu, L., Xie, L., Liu, J., Zhang, Y., & Li, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1121887 · Cited by 33
Advances in 3D culture systems for therapeutic discovery and development in brain cancer
Wanigasekara, J., Cullen, P. J., Bourke, P., Tiwari, B. K., & Curtin, J. F. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103426 · Cited by 33
pH‐ and Temperature‐responsive Hydrogels Based on Tertiary Amine‐modified Polypeptides for Stimuli‐responsive Drug Delivery
Lin, Z., Ding, J., Chen, X., & He, C. (2023) · Chemistry - An Asian Journal · doi:10.1002/asia.202300021 · Cited by 33
In Situ Antigen‐Capturing Nanochaperone Toward Personalized Nanovaccine for Cancer Immunotherapy
Li, X., Zhang, Y., Wu, X., Chen, J., Yang, M., Ma, F., & Shi, L. (2022) · Small · doi:10.1002/smll.202203100 · Cited by 32
Genome-Editing-Mediated Restructuring of Tumor Immune Microenvironment for Prevention of Metastasis
Kim, D.-Y., Wu, Y., Shim, G., & Oh, Y. (2021) · ACS Nano · doi:10.1021/acsnano.1c05420 · Cited by 31
Metformin loaded porous particles with bio-microenvironment responsiveness for promoting tumor immunotherapy
Wen, Y., Liu, Y., Chen, C., Chi, J., Zhong, L., Zhao, Y., & Zhao, Y. (2020) · Biomaterials Science · doi:10.1039/d0bm01931c · Cited by 31
Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy
Qiu, W., Liang, M., Gao, Y., Yang, X., Zhang, X., Zhang, X., Xue, P., Kang, Y., & Xu, Z. (2021) · Theranostics · doi:10.7150/thno.64354 · Cited by 30
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy
Lu, D., Li, W., Tan, J., Li, Y., Mao, W., Zheng, Y., Yang, M., Wang, J., Wang, W., Wang, S., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c09825 · Cited by 29
Self-citation
pH/ROS Dual-Responsive Polymer–Drug-Based Nanocarriers: Click-Reaction Preparation and Fluorescence Imaging-Guided Chemotherapy and Photodynamic Therapy
Zhang, N., Wang, D., Jing, X., Yang, T., Yang, H., & Meng, L. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00569 · Cited by 29
CaCO 3 nanoplatform for cancer treatment: drug delivery and combination therapy
Yang, X., Sun, Y., Zhang, H., Liu, F., Chen, Q., Shen, Q., Kong, Z., Wei, Q., Shen, J., & Guo, Y. (2024) · Nanoscale · doi:10.1039/d3nr05986c · Cited by 30
Self-citation
Designing and Engineering of Nanocarriers for Bioapplication in Cancer Immunotherapy
Li, Y., Zhang, X., Liu, X., Pan, W., Li, N., & Tang, B. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01272 · Cited by 29
Injectable hydrogels as drug delivery platform for in-situ treatment of malignant tumor
Ma, Q., Li, Q., Cai, X., Zhou, P., Wu, Z., Wang, B., Ma, W., & Fu, S. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103817 · Cited by 27
Extracellular Vesicles for Disease Treatment
Wang, F., Feng, J., Jin, A., Shao, Y., Shen, M., Ma, J., Lei, L., & Liu, L. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s506456 · Cited by 26
Nanotechnologies for enhancing cancer immunotherapy
Yang, J., Wang, C., Shi, S., & Dong, C. (2020) · Nano Research · doi:10.1007/s12274-020-2904-8 · Cited by 26
Development of cancer immunotherapy based on PD-1/PD-L1 pathway blockade
Zhang, M., Liu, K., & Wang, M. (2019) · RSC Advances · doi:10.1039/c9ra04590b · Cited by 26
In situ sustained release hydrogel system delivering GLUT1 inhibitor and chemo-drug for cancer post-surgical treatment
Wang, L., Mei, Z., Jin, G.-Y., Liu, H., Lv, S., Fu, R., Li, M., & Yao, C. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.06.034 · Cited by 26
Ultrasound-Activatable In Situ Vaccine for Enhanced Antigen Self- and Cross-Presentation to Overcome Cancer Immunotherapy Resistance
Chen, G., Wang, Y., Mo, L., Xu, X., Zhang, X., Yang, S., Huang, R., Li, R., Zhang, L., & Zhang, B. (2024) · ACS Nano · doi:10.1021/acsnano.4c04045 · Cited by 25
Self-citation
Injectable Micelle-Incorporated Hydrogels for the Localized Chemo-Immunotherapy of Breast Tumors
Qin, X., He, L., Feng, C., Fan, D., Liang, W., Wang, Q., & Fang, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c11563 · Cited by 24
Applications of pyroptosis activators in tumor immunotherapy
Bao, X., Sun, M., Meng, L., Zhang, H., Yi, X., & Zhang, P. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101191 · Cited by 24
Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection
Zhao, Y. G., Liu, S., Shi, Z., Zhu, H., Li, M., & Yu, Q. (2022) · Nano Research · doi:10.1007/s12274-022-4211-z · Cited by 23
Versatile hydrogel-based drug delivery platform for multimodal cancer therapy from bench to bedside
Mei, Y., Hu, J., Cao, Y., Gao, X., Tang, L., & Wang, W. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2024.102341 · Cited by 25
The blooming intersection of transcatheter hepatic artery chemoembolization and nanomedicine
Chen, H., Cheng, H., Wu, W., Li, D., Mao, J., Chu, C., & Liu, G. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.024 · Cited by 23
Self-citation
Research progress in tumor targeted immunotherapy
Fang, Y., Yu, A., Ye, L., & Zhai, G. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1882992 · Cited by 23
Precisely Amplifying Intracellular Oxidative Storm by Metal–Organic Coordination Polymers to Augment Anticancer Immunity
Li, S., Chen, X., Guan, S., Wang, Z., Cao, W., Luo, G., & Ling, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c04785 · Cited by 21
Overcoming T Cell Exhaustion in Tumor Microenvironment via Immune Checkpoint Modulation with Nano‐Delivery Systems for Enhanced Immunotherapy
Huang, X., & Zhang, W. (2023) · Small Methods · doi:10.1002/smtd.202301326 · Cited by 21
Recent Advances in Nanomodulators for Augmenting Cancer Immunotherapy in Cold Tumors: Insights from Drug Delivery to Drug‐Free Strategies
Zhang, L. L., Zhu, C., Zhao, J., Scimeca, L., Dong, M., Liu, R., Jia, Y., & Xu, Z. P. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202311914 · Cited by 21
Engineering SIRPα cellular membrane-based nanovesicles for combination immunotherapy
Wang, M., Wang, Y., Mu, Y., Yang, F., Yang, Z., Liu, Y., Huang, L., Liu, S., Guan, X., Xie, Z., et al. (2023) · Nano Research · doi:10.1007/s12274-023-5397-4 · Cited by 21
Self-citation
Emerging Strategies for Local Delivery of Immune Checkpoint Inhibitors to Potentiate Cancer Immunotherapy: Current Status and Future Prospects
Chen, X., Ding, W., Jiang, Y., Shi, W., Qiu, Y., Zhao, H., & Luo, X. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c12603 · Cited by 20
Injectable immunogel based on polymerized phenylboronic acid and mannan for cancer immunotherapy
Kim, S., Lee, J., Im, S., & Kim, W. J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.009 · Cited by 20
Peritumoral scaffold neutralizes tumor pH for chemotherapy sensitization and metastasis inhibition
Yan, Y., Li, J., Yi, X., Liu, C., Zhou, Z., Huang, Y., & Li, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.006 · Cited by 20
In situ biosynthesized gold nanoclusters inhibiting cancer development via the PI3K–AKT signaling pathway
Wang, M., Yu, Z., Feng, H., Wang, J., Wang, L., Zhang, Y., Yin, L., Du, Y., Jiang, H., Wang, X., et al. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01070j · Cited by 20
Self-citation
A cell-laden hydrogel as prophylactic vaccine and anti-PD-L1 amplifier against autologous tumors
Li, J., Yan, Y., Zhang, P., Ding, J., Huang, Y., Jin, Y., & Li, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.027 · Cited by 18
Reactive oxygen species-scavenging nanoparticles coated with chondroitin sulfate protect cartilage against osteoarthritis in vivo
Wang, Z., Xiong, H., Zhai, Z., Yao, Y., Zhou, T., Zhang, H., Fan, C., & Gao, C. (2022) · Nano Research · doi:10.1007/s12274-022-4934-x · Cited by 18
Inosine‐Based Supramolecular Hydrogel for Highly Efficient PD‐L1 Blockade Therapy via Mediating CD8 + T Cells
Qi, J., Ding, T., Liu, T., Xia, X., Wu, S., Liu, J., Chen, Q., Zhang, D., & Zhao, H. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202204273 · Cited by 18
Self-citation
“Cold” colorectal cancer faces a bottleneck in immunotherapy
Liu, J., Yang, M., Bai, J., Liu, Z., & Wang, X. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i2.240 · Cited by 20
Engineering Thermo-pH Dual Responsive Hydrogel for Enhanced Tumor Accumulation, Penetration, and Chemo-Protein Combination Therapy
Pang, X., Liang, S., Wang, T., Yu, S., Yang, R., Hou, T., Liu, Y., He, C., & Zhang, N. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s253990 · Cited by 17
Hitchhiking Delivery Systems: Therapeutic Hydrogels as Advanced Tools for Immunomodulatory Applications
Zhao, Y., Song, S., Zhang, J., Ren, X., & Zhao, Y. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00923 · Cited by 17
Advancing Epigenetic Combination Therapy in Oncology: Multifunctional Nano-Drug Delivery Systems for Synergistic Efficacy and Precision Modulation
Gao, T., Fu, S., Quan, X., Sun, J., Jiang, M., & Li, J. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s566173 · Cited by 17
Cascade enzymatic preparation of carboxymethyl chitosan-based multifunctional hydrogels for promoting cutaneous wound healing
Zhang, W., Wei, Y., Wei, Q., Zhao, Y., Jin, Z., Wang, Y., Ma, G., He, X., Hu, Z., & Jiang, Y. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125793 · Cited by 16
Two-pronged anti-cancer nanovaccines enpowered by exogenous/endogenous tumor-associated antigens
Yin, M., Liu, Z., Zhou, Y., Li, W., Yan, J., Cao, D., & Yin, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.024 · Cited by 16
Highly biocompatible thermosensitive nanocomposite gel for combined therapy of hepatocellular carcinoma via the enhancement of mitochondria related apoptosis
Fu, H., Huang, L., Xu, C., Zhang, J., Li, D., Ding, L., Liu, L., Dong, Y. W., Wang, W., & Duan, Y. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102062 · Cited by 16
Structurally Tunable pH-responsive Phosphine Oxide Based Gels by Facile Synthesis Strategy
Nazir, R., Parida, D., Guex, A. G., Rentsch, D., Zarei, A., Gooneie, A., Salmeia, K. A., Yar, K. M., Alihosseini, F., Sadeghpour, A., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22808 · Cited by 16
Local immunotherapy of glioblastoma: A comprehensive review of the concept
Sabahi, M., Salehipour, A., Bazl, M. S. Y., Rezaei, N., Mansouri, A., & Borghei-Razavi, H. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578146 · Cited by 15
Nano‐Regulator Inhibits Tumor Immune Escape via the “Two‐Way Regulation” Epigenetic Therapy Strategy
Liang, S., Liu, M., Mu, W., Gao, T., Gao, S., Fu, S., Yuan, S., Liu, J., Liu, Y., Jiang, D., et al. (2023) · Advanced Science · doi:10.1002/advs.202305275 · Cited by 15
Multifunctional Hydrogel Adhesive Accelerates Hemostasis and Wound Healing with Combined Programmatic Photothermal Property and Reactive Oxygen Species-Scavenging Ability
Tang, Z., Xu, Y., Li, J., Mai, H., Chen, R., Fu, J., Wang, P., Zhong, Q., Xie, J., Ning, Y., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c07716 · Cited by 14
Self-citation
Acceptor Engineering for Optimized ROS Generation Facilitates Reprogramming Macrophages to M1 Phenotype in Photodynamic Immunotherapy
Yang, G., Ni, J., Li, Y., Zha, M., Tu, Y., & Li, K. (2020) · Angewandte Chemie · doi:10.1002/ange.202013228 · Cited by 14
Oral biomimetic virus vaccine hydrogel for robust abscopal antitumour efficacy
Wang, C., Tang, H., Duan, Y., Zhang, Q., Shan, W., Wang, X., & Ren, L. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.06.102 · Cited by 14
Efficient Gene Delivery Based on Guanidyl‐Nucleic Acid Molecular Interactions
Wang, D., Song, J., Wang, J., Zhang, Z., Shen, Q. X., Wang, J., Guo, H., Wang, R., Xie, C., Lu, W., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202004783 · Cited by 14
Self-citation
Correction: Robust magnetic double-network hydrogels with self-healing, MR imaging, cytocompatibility and 3D printability
Gang, F., Yan, H., Ma, C., Jiang, L., Gu, Y., Liu, Z., Zhao, L., Wang, X., Zhang, J., & Sun, X. (2019) · Chemical Communications · doi:10.1039/c9cc90441g · Cited by 14
A Hydrogen-Bonded Organic Framework-Based Mitochondrion-Targeting Bioorthogonal Platform for the Modulation of Mitochondrial Epigenetics
Huang, C., Zhao, C., Sun, Y., Feng, T., Ren, J., & Qu, X. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c01794 · Cited by 13
Bridging immune-neurovascular crosstalk via the immunomodulatory microspheres for promoting neural repair
Xu, T., Gan, L., Chen, W., Zheng, D., Li, H., Deng, S., Qian, D., Gu, T., Lian, Q., Shen, G., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.10.031 · Cited by 13
Self-citation
Blood compatibility evaluations of CaCO 3 particles
Lin, J., Huang, L., Xiang, R., Ou, H., Li, X., Chen, A., & Liu, Z. (2021) · Biomedical Materials · doi:10.1088/1748-605x/ac19bf · Cited by 13
ROS-Responsive Hydrogel with M2 Macrophage Nanovesicles for Diabetic Wound Healing: Targeted CO Delivery to Regulate Mitochondrial Metabolism and Reprogram Wound Microbiota
Ma, C., Ding, W., Li, P., Wang, Q., Li, X., Meng, Z., & Ren, H. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c18140 · Cited by 12
Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair†
Wei, Q., Jia, L., Wang, Y., Zhang, W., Hu, Z., Wang, Q., & Wu, Q. (2023) · Chinese Journal of Chemistry · doi:10.1002/cjoc.202300264 · Cited by 12
Imaging‐Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids
Kim, S., Yun, S., Doh, J., & Kim, H. N. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400475 · Cited by 10
Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy
Zhang, G., Zhang, X., Dong, Q., Kong, S., Chen, L., Zhang, X., Gao, J.-Q., Zhang, J., & Ding, B. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s517331 · Cited by 11
In situ formed reactive oxygen species-responsive dipyridamole prodrug hydrogel: Spatiotemporal drug delivery for chemoimmunotherapy
Xiao, B., Shi, X., Xu, X., Liu, J., Pan, Y., Xu, H., Sun, W., Slater, N. K. H., Patra, H. K., Gao, J.-Q., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.08.043 · Cited by 9
Injectable Polydopamine Nanoparticle-Incorporated Hydrogels for Antiangiogenesis and Stimulating Tumoricidal Immunity to Inhibit Metastasis and Recurrence Postresection
Peng, N., Du, Y., Liu, J., Li, D., Li, Y., Deng, K., Li, L., Jia, P., Min, J., & Lin, J. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c10363 · Cited by 9
Injectable DNA-architected nanoraspberry depot-mediated on-demand programmable refilling and release drug delivery
Hsu, R., Fang, J., Shen, W., Sheu, Y.-C., Su, C., Chiang, W., & Hu, S. (2020) · Nanoscale · doi:10.1039/d0nr01185a · Cited by 9
Reprogramming tumor-immune cell communication with a radiosensitive nanoregulator for immunotherapy
Chen, Y., Liu, S., Gao, P., Pan, W., Shi, M., Wang, J., Li, N., & Tang, B. (2022) · Science China Materials · doi:10.1007/s40843-022-2140-7 · Cited by 9
Self-citation
Photoacoustic Force‐Guided Precise and Fast Delivery of Nanomedicine with Boosted Therapeutic Efficacy
Wang, J., Li, T., Ni, J., Guo, H., Kang, T., Li, Z., Zha, M., Lu, S., Zhang, C., Qi, W., et al. (2021) · Advanced Science · doi:10.1002/advs.202100228 · Cited by 9
Self-citation
Innovative approaches to melanoma treatment: a spotlight on stimuli-responsive biomaterials
Chitakunye, A. T., Ezekiel, O. C., Liu, Q., Zhang, S., Zhu, Q., & Cai, L. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb01504e · Cited by 7
Multifunctional hydrogels for synergistic therapy of cutaneous melanoma-associated tumor recurrence and wound regeneration
Li, M., Sun, Y., Hu, C., Luo, H., Li, M., & Yang, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102331 · Cited by 7
Nanoantidote for repression of acidosis pH promoting COVID‐19 infection
Liu, Q., Ruan, H., Sheng, Z., Sun, X., Li, S., Cui, W., & Li, C. (2022) · Open Research (University of Surrey) · doi:10.1002/viw.20220004 · Cited by 7
Self-citation
Locoregional Lymphatic Delivery Systems Using Nanoparticles and Hydrogels for Anticancer Immunotherapy
Cho, K. J., Cho, Y., & Kim, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122752 · Cited by 7
A Multivalent Personalized Vaccine Orchestrating Two‐Signal Activation Rebuilds the Bridge Between Innate and Adaptive Antitumor Immunity
Kou, X., He, T., Zhang, M., Wu, X., Li, X., Luo, R., Wu, R., Gou, X., Shen, M., Wu, Q., et al. (2023) · Small Methods · doi:10.1002/smtd.202300019 · Cited by 7
Real-time evaluation of a hydrogel delivery vehicle for cancer immunotherapeutics within embedded spheroid cultures
Huynh, V. A., Tatari, N., Marple, A. S. T., Savage, N. J., McKenna, D., Venugopal, C., Singh, S. K., & Wylie, R. G. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.040 · Cited by 7
Breaking Immunosuppressive Barriers by Engineered Nanoplatforms for Turning Cold Tumor to Hot
Dong, J., Huang, Y., Zhou, Z., & Sun, M. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200020 · Cited by 7
Hydrogel-based delivery systems for cutaneous melanoma therapy: from chemical design and crosslinking strategies to structure–activity relationships
Wu, Y., Zheng, W., Li, X., Wu, S., Zhou, L., Zhang, D., & Chen, Z. (2026) · RSC Advances · doi:10.1039/d6ra00728g · Cited by 6
Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
Sun, S., Shi, D., Liu, J., Lu, J., Dou, P., Zhou, Z., & Chen, Y. (2023) · Journal of Visualized Experiments · doi:10.3791/65026 · Cited by 6
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities
Chen, M., Zhou, Y. X., Fù, Y., Wang, Q., Wu, C., Pan, X., & Quan, G. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2388832 · Cited by 5
A drug-delivery depot for epigenetic modulation and enhanced cancer immunotherapy
Lai, J., Liang, J., Zhang, Y., Zhang, B., Wei, J., Fan, J., Chen, L., Chen, Z., Li, Q., Guo, D., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115687 · Cited by 6
Self-citation
Next Generation of Cancer Immunotherapy: Targeting the Cancer-Immunity Cycle with Nanotechnology
Ma, Y., & Cai, L. (2020) · Springer eBooks · doi:10.1007/978-981-15-5386-8_4 · Cited by 5
Life Engineering of Materials: Artificial Materials as Plugins for Biological Regulations
Lin, J., Hu, L., Wang, X., & Tang, R. (2025) · Advanced Materials · doi:10.1002/adma.202505767 · Cited by 4
New Strategies in Comprehensive Melanoma Treatment: Applications, Potential, and Challenges of Hydrogels
Jin, Q., Lin, S.-Q., Xue, X.-J., Wang, L.-L., Jiang, M.-Y., Wang, J., Wu, S.-F., & Hu, Y.-Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s535220 · Cited by 4
Self-citation
Nanomedicine-enabled epigenetic therapy for glioblastoma: Overcome the blood-brain barrier and therapeutic resistance
Yang, Q., Zhong, Y., Cai, S., Sheng, Z., Sun, D., Chen, P., Zhang, Y., Li, J., Wu, W., & Zhang, M. (2026) · Nano Research · doi:10.26599/nr.2026.94908472 · Cited by 3
In Situ Formed, Peritoneum‐Adhesive Immunogels Synergizing Low‐Dose Fractionated Radiotherapy Against Colorectal Peritoneal Carcinomatosis
Liu, X., Wang, M., Yan, J., Wu, F., Zhao, Z., Yang, Q., Zhou, R., Zheng, Y., Zhu, R., Chen, Y., et al. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200175 · Cited by 3
Immune checkpoint blocking in cancer therapy using thermosensitive hydrogels: a review
Tayebi-Khorrami, V., Fadaei, M. R., Fallahianshafiei, S., & Askari, V. R. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04171-2 · Cited by 3
Mechanotransduction-Epigenetic Coupling in Pulmonary Regeneration: Multifunctional Bioscaffolds as Emerging Tools
Wang, J., & Xu, A. (2025) · Pharmaceuticals · doi:10.3390/ph18101487 · Cited by 2
Self-citation

Authors: Ruan, H., Hu, Q., Wen, D., Chen, Q., Chen, G., Lu, Y., Wang, J., Cheng, H., Lu, W., & Gu, Z.
Affiliations: University of North Carolina at Chapel Hill (US)
Department of Bioengineering University of California Los Angeles CA 90095 USA
Drexel University (US)
Fudan University (CN)
Corresponding author: Lu, Weiyue
Gu, Zhen
ORCID: Ruan, Huitong
Hu, Quanyin
Wen, Di
Chen, Qian
Chen, Guojun
Wang, Jinqiang
Cheng, Hao
Lu, Weiyue
Gu, Zhen
Venue: Advanced Materials
Publisher: Wiley
Published: 2019-03-11
Volume: 31
Issue: 17
Pages: e1806957-e1806957
ISSN: 0935-9648 (ISSN-L)
1521-4095
DOI: 10.1002/adma.201806957
OpenAlex: W2922000375
Cited by: 220
References: 55
Citations by year: 2026: 8 · 2025: 15 · 2024: 31 · 2023: 32 · 2022: 40 · 2021: 38 · 2020: 39 · 2019: 17
FWCI: 11.57
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Advanced Materials (publishedVersion)
PubMed (publishedVersion)
Funders: University of North Carolina at Chapel Hill
Alfred P. Sloan Foundation
National Natural Science Foundation of China (81690263)
China Scholarship Council
Topics: Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: advanced melanoma, epigenetic modulation, zebularine, PD-1/PD-L1 blockade, anti-PD-1, ROS-responsive hydrogel, tumor microenvironment, tumor-associated antigen expression, immunosuppressive tumor microenvironment, combination immunotherapy, B16F10 melanoma
MeSH terms: Animals, Antibodies, Monoclonal, Antineoplastic Agents, Calcium Carbonate, Cytidine, Drug Therapy, Combination, Humans, Hydrogen-Ion Concentration, Immunosuppressive Agents, Immunotherapy, Melanoma, Drug Delivery Systems, Reactive Oxygen Species, Cell Line, Tumor, Nanoparticles, Tumor Microenvironment, Programmed Cell Death 1 Receptor, Antibodies, Monoclonal, Humanized, Drug Liberation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks