The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy
Abstract
Chemodynamic therapy (CDT) is an emerging therapy method that kills cancer cells by converting intracellular hydrogen peroxide (H 2 O 2) into highly toxic hydroxyl radicals (•OH). To overcome the current limitations of the insufficient endogenous H 2 O 2 and the high concentration of glutathione (GSH) in tumor cells, an intelligent nanocatalytic theranostics (denoted as PGC‐DOX) that possesses both H 2 O 2 self‐supply and GSH‐elimination properties for efficient cancer therapy is presented. This nanoplatform is constructed by a facile one‐step biomineralization method using poly(ethylene glycol)‐modified glucose oxidase (GOx) as a template to form biodegradable copper‐doped calcium phosphate nanoparticles, followed by the loading of doxorubicin (DOX). As an enzyme catalyst, GOx can effectively catalyze intracellular glucose to generate H 2 O 2, which not only starves the tumor cells, but also supplies H 2 O 2 for subsequent Fenton‐like reaction. Meanwhile, the redox reaction between the released Cu 2+ ions and intracellular GSH will induce GSH depletion and reduce Cu 2+ to Fenton agent Cu+ ions, and then trigger the H 2 O 2 to generate •OH by a Cu+‐mediated Fenton‐like reaction, resulting in enhanced CDT efficacy. The integration of GOx‐mediated starvation therapy, H 2 O 2 self‐supply and GSH‐elimination enhanced CDT, and DOX‐induced chemotherapy, endow the PGC‐DOX with effective tumor growth inhibition with minimal side effects in vivo.
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Cites
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Cited by
Tong, X., Tang, R., Xiao, M., Xu, J., Wang, W., Zhang, B., Liu, J., Yu, X., & Shi, S. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01392-3 · Cited by 883
Zhou, Y., Fan, S., Feng, L., Huang, X., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202104223 · Cited by 463
RelB-activated GPX4 inhibits ferroptosis and confers tamoxifen resistance in breast cancer
Xu, Z., Wang, X., Sun, W., Xu, F., Kou, H., Hu, W., Zhang, Y., Jiang, Q., Tang, J., & Xu, Y. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102952 · Cited by 76
Hu, B., Xiao, X., Chen, P., Qian, J., Yuan, G., Ye, Y., Zeng, L., Zhong, S., Wang, X., Qin, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121811 · Cited by 73
Glutathione-responsive and -exhausting metal nanomedicines for robust synergistic cancer therapy
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Metadata
- Authors
- Fu, L., Wan, Y., Qi, C., He, J., Li, C., Yang, C., Xu, H., Lin, J., & Huang, P.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2021-01-04
- Volume
- 33
- Issue
- 7
- Pages
- e2006892-e2006892
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W3119846021
- Cited by
- 820
- References
- 46
- FWCI
- 42.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fu, L., Wan, Y., Qi, C., He, J., Li, C., Yang, C., Xu, H., Lin, J., & Huang, P. (2021). Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy. Advanced Materials. https://doi.org/10.1002/adma.202006892
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