The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction
Abstract
Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H 2 O 2 in a tumor microenvironment: Ionization of the AFeNPs enables on‐demand ferrous ion release in the tumor, and subsequent H 2 O 2 disproportionation leads to efficient .OH generation. The endogenous stimuli‐responsive .OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.
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Citations
Cites
LXXIII.—Oxidation of tartaric acid in presence of iron
Fenton, H. J. H. (1894) · J. Chem. Soc., Trans. · doi:10.1039/ct8946500899 · Cited by 3,179
Cited by
Fu, L., Wan, Y., Qi, C., He, J., Li, C., Yang, C., Xu, H., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202006892 · Cited by 820
Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery
Guo, Y., Sun, Q., Wu, F., Dai, Y., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202007356 · Cited by 650
Liu, C., Wang, D., Zhang, S., Cheng, Y., Yang, F., Xing, Y., Xu, T., Dong, H., & Zhang, X. (2019) · ACS Nano · doi:10.1021/acsnano.8b09387 · Cited by 641
Self-citationThe acidic tumor microenvironment: a target for smart cancer nano-theranostics
Feng, L., Dong, Z., Tao, D., Zhang, Y., & Liu, Z. (2018) · National Science Review · doi:10.1093/nsr/nwx062 · Cited by 426
Wang, C., Cao, F., Ruan, Y., Jia, X., Zhen, W., & Jiang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903981 · Cited by 411
Metadata
- Authors
- Zhang, C., Bu, W., Ni, D., Zhang, S., Li, Q., Yao, Z., Zhang, J., Yao, H., Wang, Z., & Shi, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-01-06
- Volume
- 55
- Issue
- 6
- Pages
- 2101-2106
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2229268188
- Cited by
- 1,269
- References
- 1
- FWCI
- 32.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, C., Bu, W., Ni, D., Zhang, S., Li, Q., Yao, Z., Zhang, J., Yao, H., Wang, Z., & Shi, J. (2016). Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201510031
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