The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy
Abstract
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O 2 into the highly toxic hydroxyl radical (.OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with .OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO 2 is reported that has both Fenton‐like Mn 2+ delivery and GSH depletion properties. In the presence of HCO 3−, which is abundant in the physiological medium, Mn 2+ exerts Fenton‐like activity to generate .OH from H 2 O 2. Upon uptake of MnO 2‐coated mesoporous silica nanoparticles (MS@MnO 2 NPs) by cancer cells, the MnO 2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn 2+, resulting in GSH depletion‐enhanced CDT. This, together with the GSH‐activated MRI contrast effect and dissociation of MnO 2, allows MS@MnO 2 NPs to achieve MRI‐monitored chemo–chemodynamic combination therapy.
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Cites
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555
Kim, S. E., Zhang, L., Ma, K., Riegman, M., Chen, F., Ingold, I., Conrad, M., Turker, M. Z., Gao, M., Jiang, X., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.164 · Cited by 622
Small conjugate-based theranostic agents: an encouraging approach for cancer therapy
Kumar, R., Shin, W. S., Sunwoo, K., Kim, W. Y., Koo, S., Bhuniya, S., & Kim, J. S. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00224a · Cited by 381
Research works printed but not linked: 41
- 10.1073/pnas.0611142104 · DOI · Paper page
- 10.1002/anie.201611783 · DOI
- 10.1002/ange.201611783 · DOI
- 10.1002/anie.201408472 · DOI · Paper page
- 10.1002/ange.201408472 · doi:10.1002/ange.201408472
- 10.1002/anie.201510031 · DOI · Paper page
- 10.1002/ange.201510031 · DOI
- Tang Z., 2018, Adv. Mater.
- 10.1039/b922183m · DOI · Paper page
- 10.1038/6198 · DOI · Paper page
- Szatrowski T. P., 1991, Cancer Res., 51, 794
- 10.1002/anie.201504186 · doi:10.1002/anie.201504186
- 10.1002/ange.201504186 · doi:10.1002/ange.201504186
- 10.1211/jpp.59.11.0013 · DOI
- 10.1073/pnas.95.21.12468 · DOI
- 10.1038/nchembio.1416 · DOI · Paper page
- 10.1021/acs.nanolett.6b04060 · DOI · Paper page
- 10.1021/ja905938a · DOI · Paper page
- 10.1021/acs.nanolett.6b04269 · DOI · Paper page
- 10.1039/B813725K · DOI
- 10.1016/j.apcatb.2010.11.022 · DOI
- 10.1021/jacs.5b11561 · DOI
- Kuppusamy P., 2002, Cancer Res., 62, 307
- Russo A., 1986, Cancer Res., 46, 2845
- Arrick B. A., 1984, Cancer Res., 44, 4224
- 10.1016/S0074-7696(08)60166-7 · DOI · Paper page
- 10.1038/bjc.1993.484 · DOI
- 10.1002/(SICI)1096-9101(1998)23:3<161::AID-LSM5>3.0.CO;2-N · doi:10.1002/(sici)1096-9101(1998)23:3<161::aid-lsm5>3.0.co;2-n
- 10.1021/ja2100774 · DOI · Paper page
- 10.1002/adma.201001417 · DOI · Paper page
- 10.1002/adma.201504617 · DOI · Paper page
- 10.1021/nn506640h · DOI
- 10.1016/S1011-1344(02)00279-8 · DOI
- 10.1002/adma.201505869 · DOI · Paper page
- 10.1039/c3tb21479f · DOI · Paper page
- 10.1002/anie.201605509 · DOI · Paper page
- 10.1002/ange.201605509 · DOI
- 10.1021/ja046572r · DOI
- 10.1038/ncomms7907 · DOI · Paper page
- 10.1016/S0891-5849(00)00302-6 · DOI · Paper page
- 10.1021/ja2083569 · DOI
Cited by
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Fu, L., Wan, Y., Qi, C., He, J., Li, C., Yang, C., Xu, H., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202006892 · Cited by 820
Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery
Guo, Y., Sun, Q., Wu, F., Dai, Y., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202007356 · Cited by 650
Self-citationLiu, C., Wang, D., Zhang, S., Cheng, Y., Yang, F., Xing, Y., Xu, T., Dong, H., & Zhang, X. (2019) · ACS Nano · doi:10.1021/acsnano.8b09387 · Cited by 641
Wang, C., Cao, F., Ruan, Y., Jia, X., Zhen, W., & Jiang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903981 · Cited by 411
Metadata
- Authors
- Lin, L., Song, J., Song, L., Ke, K., Liu, Y., Zhou, Z., Shen, Z., Li, J., Yang, Z., Tang, W., Niu, G., Yang, H., & Chen, X.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2018-03-23
- Volume
- 57
- Issue
- 18
- Pages
- 4902-4906
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2793503277
- Cited by
- 1,466
- References
- 4
- FWCI
- 56.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Funders
- National Institute of Biomedical Imaging and Bioengineering (ZIA EB000073)
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- The paper
- Lin, L., Song, J., Song, L., Ke, K., Liu, Y., Zhou, Z., Shen, Z., Li, J., Yang, Z., Tang, W., Niu, G., Yang, H., & Chen, X. (2018). Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201712027
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