The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold
Abstract
M1 macrophage accumulation and excessive inflammation are commonly encountered issues in diabetic wounds and can fail in the healing process. Hence, hydrogel dressings with immunoregulatory capacity have great promise in the clinical practice of diabetic wound healing. However, current immunoregulatory hydrogels are always needed for complex interventions and high‐cost treatments, such as cytokines and cell therapies. In this study, a novel glycyrrhizic acid (GA)‐based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing. This hybrid hydrogel consists of interpenetrating polymer networks composed of inorganic Zn 2+‐induced self‐assembled GA and photo‐crosslinked methyl acrylated silk fibroin (SF), realizing both excellent injectability and mechanical strength. Notably, the SF/GA/Zn hybrid hydrogel can regulate macrophage responses in the inflammatory microenvironment, circumventing the use of any additives. The immunomodulatory properties of the hydrogel can be harnessed for safe and efficient therapeutics that accelerate the three phases of wound repair and serve as a promising dressing for the management of diabetic wounds.
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Cited by
Chen, Y., Wang, X., Tao, S., Wang, Q., Ma, P.-Q., Li, Z.-B., Wu, Y.-L., & Li, D.-W. (2023) · Military Medical Research · doi:10.1186/s40779-023-00473-9 · Cited by 313
Wu, M., Liu, H., Li, D., Zhu, Y., Wu, P., Chen, Z., Chen, F., Chen, Y., Deng, Z., & Cai, L. (2024) · Advanced Science · doi:10.1002/advs.202304641 · Cited by 257
Living Microecological Hydrogels for Wound Healing
Chen, G., Wang, F., Zhang, X., Shang, Y., & Zhao, Y. (2023) · Science Advances · doi:10.1126/sciadv.adg3478 · Cited by 196
Wu, M., Liu, H., Zhu, Y., Wu, P., Chen, Y., Deng, Z., Zhu, X., & Cai, L. (2024) · Theranostics · doi:10.7150/thno.97335 · Cited by 189
Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing
Ni, Z., Yu, H., Wang, L., Huang, Y., Lu, H., Zhou, H., & Liu, Q. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c15686 · Cited by 137
Metadata
- Authors
- Qian, Y., Zheng, Y., Jin, J., Wu, X., Xu, K., Dai, M., Niu, Q., Zheng, H., He, X., & Shen, J.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2022-06-13
- Volume
- 34
- Issue
- 29
- Pages
- e2200521-e2200521
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W4280504106
- Cited by
- 756
- References
- 70
- FWCI
- 52.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Qian, Y., Zheng, Y., Jin, J., Wu, X., Xu, K., Dai, M., Niu, Q., Zheng, H., He, X., & Shen, J. (2022). Immunoregulation in Diabetic Wound Repair with a Photoenhanced Glycyrrhizic Acid Hydrogel Scaffold. Advanced Materials. https://doi.org/10.1002/adma.202200521
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