Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis

Materials design for bone-tissue engineering

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Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy

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Immunoregulatory hydrogel decorated with Tannic acid/Ferric ion accelerates diabetic wound healing via regulating Macrophage polarization

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Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization

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Mild Photothermal‐Stimulation Based on Injectable and Photocurable Hydrogels Orchestrates Immunomodulation and Osteogenesis for High‐Performance Bone Regeneration

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ZnL2‑BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win–Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter

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Electroactive Biomaterials for Facilitating Bone Defect Repair under Pathological Conditions

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Mild Hyperthermia-Assisted ROS Scavenging Hydrogels Achieve Diabetic Wound Healing

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Continuously released Zn2+ in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties

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Gold nanorods modified by endogenous protein with light-irradiation enhance bone repair via multiple osteogenic signal pathways

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A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration

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Transcriptome Analysis Revealed the Symbiosis Niche of 3D Scaffolds to Accelerate Bone Defect Healing

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Engineering injectable composite scaffolds for enhanced bone healing: Integration of stem cells, hydrogels, and microspheres

Wang, H., Li, J., Feng, H., Hao, H., Ren, J., Li, Y., Li, C., Chen, J., Sun, C., Liang, J., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160593 · Cited by 5 · see citing works

Engineered nano-lubricant with photothermal-triggered drug release and acid-degradable ion delivery for osteoarthritic microenvironment regulation

Zhang, H., Yuan, S., Zheng, B., Wu, P., Zheng, K., Li, Y., Chen, Z., He, X., Wang, J., Yang, X., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168085 · Cited by 4 · see citing works

Hydrogel microspheres incorporating L-arginine/cerium-based metal-organic frameworks with reactive oxygen species scavenging and nitric oxide release for diabetic bone defects therapy

Zhou, Z., Zhang, Y., Liu, S., Zhou, J., Xi, H., Zhang, C., Luo, B., Zhou, J., Xiong, S., & Xiong, L. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168808 · Cited by 4 · see citing works

An injectable phosphocreatine-grafted gelatin hydrogel incorporating berberine-loaded copper-carbon dot nanozymes for osteoporotic bone regeneration

Zhang, C., Qian, J., Wang, Y., Wang, B., Wang, D., Dai, S., & Qin, H. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169983 · Cited by 4 · see citing works

ROS-responsive adhesive nanocomposite hydrogel promotes tendon-to-bone healing by modulating the inflammatory microenvironment and pro-differentiation

Zheng, S., Guo, J., Li, N., Lin, Y.-C.-D., Zhang, P., Li, W., & Zhang, X. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbaf107 · Cited by 4 · see citing works

3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair

Wang, C., Wang, Y., Li, X., Cao, H., Wang, C., Han, S., Chen, H., Zhao, X., & Yang, S. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102879 · Cited by 4 · see citing works

Advanced multifunctional thermo- and electro-stimulative hydrogels for bone regeneration

Zhang, Y., Wang, Y., Zou, J., Huang, J., Zhong, Q., Xu, Y., Lei, M., Chen, R., Wang, D., Li, H., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102922 · Cited by 4 · see citing works

Chiral Fe3O4/GelMA hydrogels regulate the osteoimmune microenvironment via Itgb3-mediated macrophage polarization to combat peri-implantitis

Shi, D., Mu, X., Cao, H., Hao, F., Xu, X., & Wu, L. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.03.055 · Cited by 4 · see citing works

A near-infrared regulated programmable multi-mode periosteum scaffold for sequential healing of infected bone defects

Yin, Y., Cai, Y., Dang, P., Zeng, W., Wang, L., Yan, X., Luo, Z., Liu, W., Zhu, Y., Chen, L., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.03.046 · Cited by 4 · see citing works

Black Phosphorus Nanosheets Incorporated Mesenchymal Stem Cell Spheroids for Accelerated Bone Regeneration

Li, H., Xue, Y., Zhang, T., Huang, Y., Xu, Y., Dai, Y. Q., Dong, Y., Lu, F., & Li, L. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c01056 · Cited by 4 · see citing works

Dual-functional biomimetic periosteum incorporating engineered small extracellular vesicles for treating critical bone defect with soft tissue fenestration via TGF-beta1/SMAD pathway

Zhang, Z., Shen, J., Xu, R., Yang, Y., Yu, X., Yu, D., & Deng, F. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101892 · Cited by 4 · see citing works

Cellulose-engineered janus periosteum with compartmentalized angiogenic and osteo-immunomodulatory abilities for bone regeneration

Xu, W., Liu, K., Chen, J., Liu, J., Li, S., Wang, H., Luo, B., & Meng, Q. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124444 · Cited by 4 · see citing works

Genistein-loaded, quaternized dextran/κ-carrageenan gels for bone regeneration in osteoporotic conditions

Negi, D., Bharti, M., Thakur, Y., & Singh, Y. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124529 · Cited by 4 · see citing works

Dual-Functional Interface Engineering of Mesoporous Bioactive Glass via Polydopamine Chelation for 3D-Printed Scaffolds with Synergistic Photothermal Therapy and Enhanced Osteogenesis

Ma, S., Ding, X., Tian, W., Liang, X., Zhang, P., & Yao, W. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c19186 · Cited by 4 · see citing works

Mild Photothermal Stimulation Driven Nanoparticles Hybrid Dual‐Network Hydrogels for Bone Repair

Ye, X., Gu, W., Liu, H., Chu, M., Ming, L., Wu, Y., Li, P., & Liao, J. (2026) · Small · doi:10.1002/smll.202512528 · Cited by 4 · see citing works

Development of a novel macroscopic regulation and microscopic intervention mode nanosystem for osteoporosis treatment

Meng, S., Liu, Q., Dai, R., Wang, Y., Chen, L., Wu, S., Li, J., Zhang, J., Gao, M., Kang, W., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101829 · Cited by 3 · see citing works

Chiral gold nanoparticles manipulate osteoimmune microenvironment via macrophage autophagy for bone regeneration

Wang, J., Gao, N., Wei, J., & Liao, L. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102131 · Cited by 3 · see citing works

Hierarchical Integration of MOF‐Based Nanoplatforms with Electrospun Nanofiber Scaffolds for Spatiotemporally Sustained Diabetic Wound Healing

Wang, Q., Xu, J., Xu, Y., Chen, X., Gao, X., Li, J., Xu, Q., Liu, F., & Li, Y. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503699 · Cited by 3 · see citing works

A pH-responsive nanocarrier delivered by carbine-crosslinked hydrogel paints for smart immunomodulation in arthroscopic cartilage repair

Jia, Q., Yakufu, M., Luo, Z., Li, G.-H., Liu, Y., Wang, Z., Song, X., Ma, C., Tuxun, H., Zhang, P., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169581 · Cited by 3 · see citing works

From physical modalities to energy-responsive biomaterials: Current strategies and challenges in tendon-to-bone healing

Zhang, L., Tan, J., Liao, B., Huang, M., Huang, R., Zhang, X., He, X., Li, X., Ding, X., Jiang, A., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.11.014 · Cited by 3 · see citing works

Programmable Photothermal and Pyroelectric Responses in a Flexible PVDF-Based Hybrid Film for Stimuli-Responsive Biointerfaces

Liu, Z., Wu, H., Wu, H., Cai, X., Wu, C., Wu, Y., Wang, F., Weng, W., Cheng, K., & Chen, J. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01519 · Cited by 3 · see citing works

Extracellular matrix-mimetic enhanced porous bioscaffolds for accelerating bone defect repair

Zhang, B., Li, Z., Zhang, Z., Gao, Y., Xing, Y., Fan, B., Tang, Y., Xu, S., Tong, C., Zhang, J., et al. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.115301 · Cited by 3 · see citing works

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Huang, Y., Zhang, Y., Feng, Y., Yang, Q., Gao, B., Xu, H., Huang, C., Lin, K., Xu, Y., & Zhu, P. (2025) · Advanced Science · doi:10.1002/advs.202518796 · Cited by 3 · see citing works

Sonodynamic biodegradable pseduo-conjugate polymer delivery of warfarin for inducing generation of cancerous ROS and ferroptosis

Wang, P., Na, J., Liu, X., Cui, M., Liang, G., He, X., Xiao, H., Zhao, Y., Liao, Y., & Zhong, L. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102891 · Cited by 3 · see citing works

Bamboo-based biomass materials with biomimetic structure and osteoconductive capability for bone regeneration

Xia, S., Zhao, M., Hu, L., Ma, S., Deng, H., Dong, X., & Sa, Y. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.173769 · Cited by 3 · see citing works

Erythropoietin Functionalized Hierarchical Scaffolds Enable Immunomodulated and Vascularized Bone Repair in Periodontal Defect

Zhang, X., Liu, J., Li, Y., Li, W., Gu, D., Chong, Y. T., Yang, X., Wang, F., & Sun, W. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c24484 · Cited by 3 · see citing works

Dual-Metal Synergy in Soy Protein Adhesives: Silver and Zinc Ions Co-Anchor on a Nanoporous Framework for Enhanced Bonding, Water Resistance, and Mold Resistance

Liao, Y., Zhao, F., Zeng, S., Li, S., Ye, Y., Jiang, K., Xiao, H. N., & Chen, Y. H. (2026) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.5c12976 · Cited by 3 · see citing works

An Engineered SIM@ZIF-8 Hydrogel Synergistically Enhances Vascularized Bone Regeneration in an Osteoporotic Environment

Ye, B., Wen, W., Xiang, R., Hua, C., Hong, G., & Luo, F. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c25724 · Cited by 3 · see citing works

Brake–Drive Osteo System: Sequential Modulation of the Inflammatory Microenvironment and Osteogenesis for Osteoporotic Bone Defect Regeneration

Xiao, Z., Feng, C., Xu, C., Zhu, C., Chen, Q., Li, Q., Liu, L., Li, X., Zhu, X., Song, Y., et al. (2026) · Advanced Materials · doi:10.1002/adma.72909 · Cited by 3 · see citing works

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Wang, Y., Chen, R. G., Chen, Y., Lu, H., Qian, Y., Gao, Z., Shen, Z., Zheng, X., Yang, H., Zou, J., et al. (2026) · Advanced Materials · doi:10.1002/adma.73803 · Cited by 3 · see citing works

Multifunctional MXene/PVDF nanofiber membrane with electroactivity and mild photothermal effect for guided bone regeneration

Zhong, Y., Lai, Y., He, D., Lan, K., Ye, S., Wu, Y., Fu, Y., & Mo, A. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115937 · Cited by 3 · see citing works

A self-assembly strategy for fabricating tough and magneto-responsive scaffolds to promote osteogenesis with enhanced vascularization

Zhou, Y., Liang, H., Liu, C., Fu, W., Jiang, X., & Tan, H. S. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.163129 · Cited by 3 · see citing works

Dopamine Carbon Dots Synergize with Mild Photothermal Therapy for Anti-Inflammatory Treatment of Periodontitis

Zhao, T., Mu, M., Yin, H., Yang, Y., Bu, W., & Sun, H. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00327 · Cited by 2 · see citing works

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Tokmedash, M. A., Robins, J., VanEpps, J. S., Kim, M., & Min, J. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502451 · Cited by 2 · see citing works

Progranulin-loaded silk fibroin/chitosan scaffold with polydopamine modification promotes bone regeneration via PI3K/Akt pathway activation

Ning, W., Wang, C., Hu, P., Lin, K., Xu, Z., Wei, W., Lin, Y., & Wu, D. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148030 · Cited by 2 · see citing works

Mechanical energy-charged navigating pump repair natural vascular scaffolds to reverse osteoporosis

Wang, F., Yang, S., Zhu, Y., Zhang, Y., He, W., Zhang, S., Xiao, J., Fu, C., Wang, P., Chen, J., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102431 · Cited by 2 · see citing works

Silk fibroin nanofibers for infectious bone defect repair: From structural functionalization to immune-regenerative translation

Zheng, Z., Gao, J., Chen, J., Ma, T., Yang, H., Zhang, H., Jiang, J., Zhang, N., & Lei, X. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115223 · Cited by 2 · see citing works

Photothermal-driven multifunctional injectable hydrogel platform for promoting diabetic bone defect repair through synergistic immunomodulation and bone homeostasis

Zhu, Y., Liu, H., Yang, Z., He, Y., Wu, P., Cai, L., Yao, L., Zhu, X., & Wu, M. (2026) · Theranostics · doi:10.7150/thno.130240 · Cited by 18 · see citing works

Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects in situ

Zhu, Y., Liu, H., Wu, P., Chen, Y., Deng, Z., Cai, L., & Wu, M. (2024) · Theranostics · doi:10.7150/thno.102779 · Cited by 202 · see citing works

Spatiotemporally coordinated immunometabolic-hyperthermia therapy for diabetic bone defect regeneration

汪铃添, Peng, X., Zheng, L., Liu, Y., Chen, L., Li, X., & Wang, Z. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103767

Smart‐Responsive Multifunctional Therapeutic System for Improved Regenerative Microenvironment and Accelerated Bone Regeneration via Mild Photothermal Therapy

Wu, M., Liu, H., Li, D., Zhu, Y., Wu, P., Chen, Z., Chen, F., Chen, Y., Deng, Z., & Cai, L. (2023) · Advanced Science · doi:10.1002/advs.202304641 · Cited by 269 · see citing works

Photoactivated MXene Nanosheets for Integrated Bone–Soft Tissue Therapy: Effect and Potential Mechanism

Qu, X., Guo, Y., Xie, C., Li, S., Liu, Z., & Lei, B. (2023) · ACS Nano · doi:10.1021/acsnano.2c10103 · Cited by 100 · see citing works