The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy
Open accessAbstract
Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H 2 O 2 in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine, CaO 2@DOX@ZIF‐67, via a bottom‐up approach is described. CaO 2@DOX@ZIF‐67 simultaneously supplies O 2 and H 2 O 2 to achieve improved chemo/chemodynamic therapy. In the weakly acidic environment within tumors, CaO 2@DOX@ZIF‐67 is broken down to rapidly release the Fenton‐like catalyst Co 2+ and the chemotherapy drug doxorubicin (DOX). The unprotected CaO 2 reacts with H 2 O to generate both O 2 and H 2 O 2. The generated O 2 relieves the hypoxia in the tumor and further improve the efficacy of DOX. Meanwhile, the generated H 2 O 2 reacts with Co 2+ ions to produce highly toxic •OH through a Fenton‐like reaction, resulting in improved chemodynamic therapy.
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Huang, C.-C., Chia, W.-T., Chung, M.-F., Lin, K.-J., Hsiao, C.-W., Jin, C., Lim, W.-H., Chen, C.-C., & Sung, H.-W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b01784 · Cited by 372
Cited by
Zhou, Y., Fan, S., Feng, L., Huang, X., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202104223 · Cited by 463
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He, J., Fu, L.-H., Qi, C., Lin, J., & Huang, P. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.026 · Cited by 93
Zhang, R., Jiang, G., Gao, Q., Wang, X., Wang, Y., Xu, X., Yan, W., & Shen, H. (2021) · Nanoscale · doi:10.1039/d1nr04687j · Cited by 61
Ghasemian, M., Kazeminava, F., Naseri, A., Mohebzadeh, S., Abbaszadeh, M., Kafil, H. S., & Ahmadian, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115328 · Cited by 55
Wang, Y., Tang, Q., Wu, R., Yang, S., Geng, Z., He, P., Li, X., Chen, Q., & Liang, X. (2024) · ACS Nano · doi:10.1021/acsnano.3c11174 · Cited by 49
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Metadata
- Authors
- Gao, S., Jin, Y., Ge, K., Li, Z., Liu, H., Dai, X., Zhang, Y., Chen, S., Liang, X., & Zhang, J.
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2019-10-24
- Volume
- 6
- Issue
- 24
- Pages
- 1902137-1902137
- ISSN
- 2198-3844 (ISSN-L)
- OpenAlex
- W2982280565
- Cited by
- 370
- References
- 1
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gao, S., Jin, Y., Ge, K., Li, Z., Liu, H., Dai, X., Zhang, Y., Chen, S., Liang, X., & Zhang, J. (2019). Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy. Advanced Science. https://doi.org/10.1002/advs.201902137
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