Cited by 58Nanoplatforms for cancer theranosticsTannin, Tannase and Anticancer ActivitiesPhytochemicals and Antioxidant Activities

Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: A review

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Ghasemian, Motaleb, Kazeminava, Fahimeh, Naseri, Ashkan, Mohebzadeh, Soheila, Abbaszadeh, Mahmoud, Kafil, Hossein Samadi, Ahmadian, Zainab·2023·Biomedicine & Pharmacotherapy

Abstract

Significant advancements have been noticed in cancer therapy for decades. Despite this, there are still many critical challenges ahead, including multidrug resistance, drug instability, and side effects. To overcome obstacles of these problems, various types of materials in biomedical research have been explored. Chief among them, the applications of natural compounds have grown rapidly due to their superb biological activities. Natural compounds, especially polyphenolic compounds, play a positive and great role in cancer therapy. Tannic acid (TA), one of the most famous polyphenols, has attracted widespread attention in the field of cancer treatment with unique structural, physicochemical, pharmaceutical, anticancer, antiviral, antioxidant and other strong biological features. This review concentrated on the basic structure along with the important role of TA in tuning oncological signal pathways firstly, and then focused on the use of TA in chemotherapy and preparation of delivery systems including nanoparticles and hydrogels for cancer therapy. Besides, the application of TA/Fe3+ complex coating in photothermal therapy, chemodynamic therapy, combined therapy and theranostics is discussed.

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Crossref · 10.1016/j.biopha.2023.115328

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Authors
Ghasemian, M., Kazeminava, F., Naseri, A., Mohebzadeh, S., Abbaszadeh, M., Kafil, H. S., & Ahmadian, Z.
Affiliations
  • Lorestan University of Medical Sciences (IR)
  • Tabriz University of Medical Sciences (IR)
  • University of Mohaghegh Ardabili (IR)
Corresponding author
  • Kafil, Hossein Samadi
  • Ahmadian, Zainab
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2023-10
Volume
166
Pages
115328
ISSN
0753-3322 (ISSN-L)
OpenAlex
W4385847696
Cited by
55
References
213
Citations by year
2026: 13 · 2025: 26 · 2024: 15 · 2023: 1
FWCI
1.23
Type
journal article
Language
en
Open access
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Lorestan University of Medical Sciences
  • Tabriz University of Medical Sciences
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Tannin, Tannase and Anticancer Activities
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
tannic acid, polyphenols, cancer therapy, anticancer activity, chemotherapy, drug delivery systems, nanoparticles, hydrogels, photothermal therapy, chemodynamic therapy, Fe3+ complexes, theranostics, multidrug resistance
MeSH terms
Biocompatible Materials, Humans, Neoplasms, Tannins, Polyphenols

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