Cited by 93Nanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis

Metal peroxides for cancer treatment

Open access
He, Jin, Fu, Lian-Hua, Qi, Chao, Lin, Jing, Huang, Peng·2021·Bioactive Materials

Abstract

In recent years, metal peroxide (MO2) such as CaO2 has received more and more attention in cancer treatment. MO2 is readily decompose to release metal ions and hydrogen peroxide in the acidic tumor microenvironment (TME), resulting metal ions overloading, decreased acidity and elevated oxidative stress in TME. All of these changes making MO2 an excellent tumor therapeutic agent. Moreover, by combining MO2 with photosensitizers, enzymes or Fenton reagents, MO2 can assist and promote various tumor therapies such as photodynamic therapy and chemodynamic therapy. In this review, the synthesis and modification methods of MO2 are introduced, and the representative studies of MO2-based tumor monotherapy and combination therapy are discussed in detail. Finally, the current challenges and prospects of MO2 in the field of tumor therapy are emphasized to promote the development of MO2-based cancer treatment.

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Crossref · 10.1016/j.bioactmat.2021.01.026

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  • Catalase and manganese dioxide can use H2O2 as a raw material to generate abundant oxygen, acting as oxygen generators to improve tumor oxygenation and existing therapeutic efficacy.

    “Materials such as catalase (CAT) 232 , 233 , 234 and manganese dioxide (MnO2) 235 , 236 can use H2O2 as a raw material to generate abundant oxygen, acting as oxygen generators to improve tumor oxygenation and existing therapeutic efficacy.”

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Authors
He, J., Fu, L.-H., Qi, C., Lin, J., & Huang, P.
Affiliations
  • Shenzhen University (CN)
  • Chongqing University (CN)
Corresponding author
Huang, Peng
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2021-09
Volume
6
Issue
9
Pages
2698-2710
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
OpenAlex
W3133754753
Cited by
93
References
93
Citations by year
2026: 5 · 2025: 14 · 2024: 28 · 2023: 24 · 2022: 14 · 2021: 8
FWCI
1.56
Type
journal article
Language
en
Open access
Locations
  • Bioactive Materials (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20170412111100742, JCYJ20180507182413022)
  • National Key Research and Development Program of China (2018YFA0704000)
  • Fundamental Research Funds for the Central Universities (2020CDJQY-A060)
  • Shenzhen Science and Technology Innovation Program (KQTD20190929172538530)
  • National Natural Science Foundation of China (21807074, 31900945, 51802202, 82071985)
  • Natural Science Foundation of Guangdong Province (2018B030308003)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
Keywords
metal peroxides, calcium peroxide, cancer therapy, tumor microenvironment, metal ion release, hydrogen peroxide, oxidative stress, photodynamic therapy, chemodynamic therapy, photosensitizers, Fenton reagent, combination therapy

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