Metal peroxides for cancer treatment
Open accessAbstract
In recent years, metal peroxide (MO2) such as CaO2 has received more and more attention in cancer treatment. MO2 is readily decompose to release metal ions and hydrogen peroxide in the acidic tumor microenvironment (TME), resulting metal ions overloading, decreased acidity and elevated oxidative stress in TME. All of these changes making MO2 an excellent tumor therapeutic agent. Moreover, by combining MO2 with photosensitizers, enzymes or Fenton reagents, MO2 can assist and promote various tumor therapies such as photodynamic therapy and chemodynamic therapy. In this review, the synthesis and modification methods of MO2 are introduced, and the representative studies of MO2-based tumor monotherapy and combination therapy are discussed in detail. Finally, the current challenges and prospects of MO2 in the field of tumor therapy are emphasized to promote the development of MO2-based cancer treatment.
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Catalase and manganese dioxide can use H2O2 as a raw material to generate abundant oxygen, acting as oxygen generators to improve tumor oxygenation and existing therapeutic efficacy.
“Materials such as catalase (CAT) 232 , 233 , 234 and manganese dioxide (MnO2) 235 , 236 can use H2O2 as a raw material to generate abundant oxygen, acting as oxygen generators to improve tumor oxygenation and existing therapeutic efficacy.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [237]
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- Authors
- He, J., Fu, L.-H., Qi, C., Lin, J., & Huang, P.
- Affiliations
- Shenzhen University (CN)
- Chongqing University (CN)
- Corresponding author
- Huang, Peng
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 6
- Issue
- 9
- Pages
- 2698-2710
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- PMC
- PMC7895646
- OpenAlex
- W3133754753
- Cited by
- 93
- References
- 93
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 28 · 2023: 24 · 2022: 14 · 2021: 8
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Bioactive Materials (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20170412111100742, JCYJ20180507182413022)
- National Key Research and Development Program of China (2018YFA0704000)
- Fundamental Research Funds for the Central Universities (2020CDJQY-A060)
- Shenzhen Science and Technology Innovation Program (KQTD20190929172538530)
- National Natural Science Foundation of China (21807074, 31900945, 51802202, 82071985)
- Natural Science Foundation of Guangdong Province (2018B030308003)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
- Keywords
- metal peroxides, calcium peroxide, cancer therapy, tumor microenvironment, metal ion release, hydrogen peroxide, oxidative stress, photodynamic therapy, chemodynamic therapy, photosensitizers, Fenton reagent, combination therapy
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