The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
Open accessAbstract
Ferroptosis is a new form of regulated cell death, which is characterized by the iron‐dependent accumulation of lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid cycle are involved in the regulation of key ferroptosis markers such as reduced nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH), and reactive oxygen species (ROS), therefore imposing potential regulatory roles in ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit ferroptosis for self‐preservation such as the upregulation of glycolysis and PPP. Due to the rapid proliferation of tumor cells and the intensified metabolic rate, tumor energy metabolism has become a target for disrupting the redox homeostasis and induce ferroptosis. Based on these emerging insights, regulatory impact of those‐tumor specific metabolic aberrations is systematically characterized, such as rewired glucose metabolism and metabolic compensation through glutamine utilization on ferroptosis and analyzed the underlying molecular mechanisms. Additionally, those ferroptosis‐based therapeutic strategies are also discussed by exploiting those metabolic vulnerabilities, which may open up new avenues for tumor treatment in a clinical context.
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Tumour heterogeneity and resistance to cancer therapies
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Metadata
- Authors
- Yao, X., Li, W., Fang, D., Xiao, C., Wu, X., Li, M., & Luo, Z.
- Venue
- Advanced Science
- Publisher
- Wiley
- Published
- 2021-10-10
- Volume
- 8
- Issue
- 22
- Pages
- e2100997-e2100997
- ISSN
- 2198-3844 (ISSN-L)
- OpenAlex
- W3207848283
- Cited by
- 282
- References
- 143
- FWCI
- 24.68
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yao, X., Li, W., Fang, D., Xiao, C., Wu, X., Li, M., & Luo, Z. (2021). Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells. Advanced Science. https://doi.org/10.1002/advs.202100997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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