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Cited by 519Nanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesWound Healing and Treatments

Engineering robust Ag-decorated polydopamine nano-photothermal platforms to combat bacterial infection and prompt wound healing

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Qi, Xiaoliang, Huang, Yijing, You, Shengye, Xiang, Yajing, Cai, Erya, Mao, Ruiting, Pan, Wenhao, Tong, Xianqin +3 more·2022·Advanced Science
DOI 10.1002/advs.202106015PMC PMC9008420
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Abstract

Polydopamine (PDA) nanoparticles have emerged as an attractive biomimetic photothermal agent in photothermal antibacterial therapy due to their ease of synthesis, good biodegradability, long‐term safety, and excellent photostability. However, the therapeutic effects of PDA nanoparticles are generally limited by the low photothermal conversion efficiency (PCE). Herein, PDA@Ag nanoparticles are synthesized via growing Ag on the surface of PDA nanoparticles and then encapsulated into a cationic guar gum (CG) hydrogel network. The optimized CG/PDA@Ag platform exhibits a high PCE (38.2%), which is more than two times higher than that of pure PDA (16.6%). More importantly, the formulated CG/PDA@Ag hydrogel with many active groups can capture and kill bacteria through effective interactions between hydrogel and bacteria, thereby benefiting the antibacterial effect. As anticipated, the designed CG/PDA@Ag system combined the advantages of PDA@Ag nanoparticles (high PCE) and hydrogel (preventing aggregation of PDA@Ag nanoparticles and possessing inherent antibacterial ability) is demonstrated to have superior antibacterial efficacy both in vitro and in vivo. This study develops a facile approach to boost the PCE of PDA for photothermal antibacterial therapy, providing a significant step forward in advancing the application of PDA nano‐photothermal agents.

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  • Mussel-inspired polydopamine (PDA)-based nanomaterials possess a photothermal effect; therefore, a hydrogel containing PDA-based nanomaterials usually shows photothermal antibacterial capability.

    “Additionally, mussel-inspired polydopamine (PDA)-based nanomaterials possess a photothermal effect; therefore, a hydrogel containing PDA-based nanomaterials usually shows photothermal antibacterial capability [85,86].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [85]

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Cited by

Sorted by citations

Authors
Qi, X., Huang, Y., You, S., Xiang, Y., Cai, E., Mao, R., Pan, W., Tong, X., Dong, W., Ye, F., & Shen, J.
Affiliations
  • Wenzhou Medical University (CN)
  • Nanjing University of Science and Technology (CN)
  • Wenzhou Institute, University of Chinese Academy of Sciences (CN)
Corresponding author
  • Dong, Wei
  • Ye, Fangfu
  • Shen, Jianliang
ORCID
Venue
Advanced Science
Publisher
Wiley
Published
2022-02-22
Volume
9
Issue
11
Pages
e2106015-e2106015
ISSN
2198-3844 (ISSN-L)
DOI
10.1002/advs.202106015
PMC
PMC9008420
OpenAlex
W4212772261
Cited by
519
References
1
Citations by year
2026: 66 · 2025: 125 · 2024: 159 · 2023: 123 · 2022: 46
FWCI
32.91
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (21977081, 31800833)
  • Wenzhou Medical University (KYYW201906, KYYW201901)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
polydopamine nanoparticles, silver nanoparticles, photothermal antibacterial therapy, photothermal conversion efficiency, wound healing, bacterial infection, nanoparticle aggregation prevention
MeSH terms
Anti-Bacterial Agents, Bacterial Infections, Humans, Indoles, Polymers, Silver, Wound Healing, Hydrogels, Metal Nanoparticles

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